energy

能源
  • 文章类型: Journal Article
    制备具有持久钝化效果的钙钛矿太阳能电池(PSC)是具有挑战性的。这里,我们提出了一种制造高效和稳定的钝化钙钛矿太阳能电池的协议。我们描述了通过化学浴沉积和钙钛矿膜制备电子传输层(ETL)的步骤。然后,我们详细介绍了用过量的三联吡啶配体钝化表面缺陷的程序和稳定性表征。该协议具有钝化剂-三吡啶,其钝化效果与浓度无关,大大提高了钝化的耐久性。有关此协议的使用和执行的完整详细信息,请参考王等人。1.
    Preparation of perovskite solar cells (PSCs) with long-lasting passivation effectiveness is challenging. Here, we present a protocol for fabricating efficient and stable passivated perovskite solar cells. We describe steps for preparing the electron transporting layer (ETL) via chemical bath deposition and perovskite film. We then detail procedures for passivating the surface defects with excess terpyridine ligands and stability characterization. This protocol features a passivator-terpyridine whose passivation effect is independent of concentration, which greatly improves the durability of the passivation. For complete details on the use and execution of this protocol, please refer to Wang et al.1.
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  • 文章类型: Journal Article
    背景:在重症监护病房中,值得注意的是,在治疗和护理过程中大量使用资源,导致大量的废物产生。此外,对重症监护的需求,延长预期寿命和手术干预,复杂的合并症和生态危机使重症监护更加可持续发展成为必要。
    目的:探讨外科重症监护病房护士对负责任医疗废物管理的看法,能量和药物消耗。
    方法:这项定性描述性研究于2023年11月在土耳其一所大学医院的外科重症监护病房进行。23名护士填写了介绍性表格,并参加了半结构化面试。使用归纳内容分析对数据进行分析。
    结果:确定了三个主要主题:环境可持续的重症监护,预防重症监护中的废物;负责任的消费和回收;关于环境可持续性的机构和个人行为变化的建议。
    结论:大多数护士缺乏关于可持续发展目标的知识。然而,在重症监护室,他们为医疗废物管理提供了有效和创造性的解决方案,能源和药物消费以及关于环境可持续性的个人和机构行为变化。
    结论:机构应制定可持续发展战略,以确保负责任的医疗废物管理,能源和医药消费,减少碳足迹。根据这一目的,\'绿色团队\'包括以单位为基础的医生,应该建立护士和护理人员。应提供培训,并应提高意识,以减少供暖导致的能源使用,照明,通风和空调。
    BACKGROUND: In intensive care units, it is noticeable that there is intensive use of resources in the treatment and care process, leading to a significant amount of waste generation. In addition, the demand for intensive care, increasing life expectancy and surgical interventions, complex comorbidities and ecological crisis make it necessary to make critical care more sustainable.
    OBJECTIVE: To explore the perspectives of nurses working in surgical intensive care units regarding responsible medical waste management, energy and medication consumption.
    METHODS: This qualitative descriptive study was conducted in surgical intensive care units of a university hospital in Turkey in November 2023. Twenty-three nurses filled in an introductory form and participated in a semi-structured interview. Data were analysed using inductive content analysis.
    RESULTS: Three main themes were determined: environmentally sustainable intensive care, prevention of waste in intensive care; responsible consumption and recycling; suggestions for institutional and individual behavioural change regarding environmental sustainability.
    CONCLUSIONS: The majority of nurses lack knowledge about sustainable development goals. However, in the intensive care unit, they provided effective and creative solutions for medical waste management, energy and medication consumption and individual and institutional behavioural change regarding environmental sustainability.
    CONCLUSIONS: Sustainability strategies should be created in institutions to ensure responsible medical waste management, energy and medicine consumption and reduce carbon footprint. In accordance with this purpose, \'Green teams\' including unit-based doctors, nurses and paramedics should be established. Training should be provided and awareness should be raised to reduce energy use resulting from heating, lighting, ventilation and air conditioning.
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  • 文章类型: Journal Article
    背景:2022年4月6日,英国立法生效,要求将卡路里标签应用于大型食品企业菜单上的食品。这项研究旨在评估卡路里标签对(a)购买的食物和(b)工作场所自助餐厅菜单选项的能量含量的影响。
    方法:从2022年1月至2022年10月,从142个工地自助餐厅获得了产品级销售数据和可用物品的能量含量。具有水平和斜率变化的中断时间序列(ITS)分析评估了每件物品购买的每日能量(kcal),和ITS,其水平变化评估了卡路里标签前后菜单上每个选项的平均能量。每个分析在实施后6周和6个月进行。事后ITS检查了更长时期内(2021年3月至2022年10月;135个站点)的每个项目每周购买的能源。
    结果:没有证据表明卡路里标签会改变购买食品的能量含量(6周:0.60cal/产品,95CI:-2.54,+3.75;6个月:+1.59卡/产品,95CI:-0.96,+4.16)。事后分析表明,随着时间的推移,卡路里标签与购买物品的平均能量减少相关(-0.65千卡/周,95CI:-0.81,-0.49),但显著增加(+3千卡,95CI:+0.43,+5.60)在实施时。每次季节性菜单更改时,菜单选项的平均能量含量都会减少(2022年4月:-1.79千卡,95CI:-3.42,-0.15;2022年7月:-4.18大卡,95%CI:-7.65,-0.73)。
    结论:这项在工作场所自助餐厅进行的大型观察性研究没有发现任何证据表明引入卡路里标签会导致客户购买的能量立即减少。有一些证据表明,随着时间的推移,影响越来越大,可能与菜单产品的变化有关,但这种影响很小,不能直接归因于卡路里标签。
    BACKGROUND: On 6 April 2022, legislation came into effect in England requiring calorie labels to be applied to food items on menus of larger food businesses. This study aimed to assess the impact of calorie labelling on (a) food purchased and (b) energy content of menu options in worksite cafeterias.
    METHODS: Product-level sales data and energy content of available items was obtained from 142 worksite cafeterias from January 2022-October 2022. Interrupted-time-series (ITS) analysis with level and slope change evaluated daily energy (kcal) purchased per item, and ITS with level change assessed mean energy per option available on menus before and after calorie labelling. Each analysis was conducted 6 weeks and 6 months from implementation. A post-hoc ITS examined weekly energy purchased per item over a longer period (March 2021-October 2022; 135 sites).
    RESULTS: There was no evidence calorie labelling changed the energy content of foods purchased (6-week: + 0.60 cal/product, 95%CI:-2.54, + 3.75; 6-month: + 1.59 cal/product, 95%CI:-0.96, + 4.16). Post-hoc analyses suggested calorie labels were associated with a reduction in mean energy of items purchased over time (-0.65 kcal/week, 95%CI:-0.81,-0.49), but a significant increase (+ 3 kcal, 95%CI: + 0.43, + 5.60) at the point of implementation. There was a reduction in the mean energy content of menu options at each seasonal menu change (April 2022:-1.79 kcal, 95%CI:-3.42,-0.15; July 2022:-4.18 kcal, 95% CI:-7.65,-0.73).
    CONCLUSIONS: This large observational study in worksite cafeterias found no evidence to indicate the introduction of calorie labelling led to any immediate reduction in energy purchased by customers. There was some evidence of increasing impact over time, possibly associated with changes in menu offerings, but this effect was small and cannot be directly attributed to calorie labelling.
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  • 文章类型: Journal Article
    Leber的遗传性视神经病变(LHON)是一种与线粒体DNA(mtDNA)突变相关的使人衰弱的线粒体疾病。不幸的是,由于线粒体替代的挑战,LHON患者的可用治疗选择有限.在我们的研究中,我们将LHON尿液细胞重编程为诱导多能干细胞(iPSCs),并将其分化为神经祖细胞(NPCs)和神经元,用于疾病建模.我们的研究表明,LHON神经元表现出显著较高水平的mtDNA突变和线粒体功能降低。确认疾病表型。然而,通过将LHONiPSC衍生的NPCs与间充质干细胞(MSCs)共培养,我们观察到突变mtDNA的显着拯救和LHON神经元线粒体代谢功能的显着改善。这些发现表明,与MSCs共培养可以增强LHONNPCs的线粒体功能,甚至在它们分化为神经元之后。这一发现有望成为LHON患者的潜在治疗策略。
    Leber\'s hereditary optic neuropathy (LHON) is a debilitating mitochondrial disease associated with mutations in mitochondrial DNA (mtDNA). Unfortunately, the available treatment options for LHON patients are limited due to challenges in mitochondrial replacement. In our study, we reprogramming LHON urine cells into induced pluripotent stem cells (iPSCs) and differentiating them into neural progenitor cells (NPCs) and neurons for disease modeling. Our research revealed that LHON neurons exhibited significantly higher levels of mtDNA mutations and reduced mitochondrial function, confirming the disease phenotype. However, through co-culturing LHON iPSC-derived NPCs with mesenchymal stem cells (MSCs), we observed a remarkable rescue of mutant mtDNA and a significant improvement in mitochondrial metabolic function in LHON neurons. These findings suggest that co-culturing with MSCs can enhance mitochondrial function in LHON NPCs, even after their differentiation into neurons. This discovery holds promise as a potential therapeutic strategy for LHON patients.
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  • 文章类型: Journal Article
    该项目旨在开发用于可持续能源应用的多孔材料,即,储氢,以及生物质向可再生燃料的增值。该项目的核心是针对非洲研究人员的培训计划,内容包括:(i)开发当地可利用的可再生原材料;(ii)使用先进的最新技术设计和合成多孔材料(沸石和金属有机骨架(MOFs)),以储存能量;(iii)将可持续的低价值原料用于可再生燃料。我们发现,在高压下压缩UiO-66MOF可以提高体积储氢能力,而重量吸收没有任何损失。并通过实验证明了UiO-66的温度依赖性动态行为,这使我们能够为UiO-66提出≤150°C的活化温度。共造粒用于将UiO-66/纳米纤维整料制造为具有增强的可用(即可交付)储氢能力的分层多孔材料。我们阐明了使用天然存在的高岭土作为沸石合成的二氧化硅和氧化铝物种的来源。高岭土衍生的沸石X已成功用作麻疯树油(来自非食用生物质)酯交换为生物柴油的催化剂。我们还制备了成功应用于电化学传感的多孔复合材料(即碳/UiO-66,有机粘土/UiO-66和沸石/碳)。
    The project aimed to develop porous materials for sustainable energy applications, namely, hydrogen storage, and valorization of biomass to renewable fuels. At the core of the project was a training programme for Africa-based researchers in (i) the exploitation of renewable locally available raw materials; (ii) the use of advanced state-of-the-art techniques for the design and synthesis of porous materials (zeolites and metal-organic frameworks (MOFs)) for energy storage; and (iii) the valorization of sustainable low-value feedstock to renewable fuels. We found that compaction of the UiO-66 MOF at high pressure improves volumetric hydrogen storage capacity without any loss in gravimetric uptake, and experimentally demonstrated the temperature-dependent dynamic behaviour of UiO-66, which allowed us to propose an activation temperature of ≤ 150°C for UiO-66. Co-pelletization was used to fabricate UiO-66/nanofibre monoliths as hierarchical porous materials with enhanced usable (i.e. deliverable) hydrogen storage capacity. We clarified the use of naturally occurring kaolin as a source of silica and alumina species for zeolite synthesis. The kaolin-derived zeolite X was successfully used as a catalyst for the transesterification of Jatropha curcas oil (from non-edible biomass) to biodiesel. We also prepared porous composites (i.e. carbon/UiO-66, organoclay/UiO-66 and zeolite/carbon) that were successfully applied in electrochemical sensing.
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  • 文章类型: Journal Article
    目的:本文旨在提出一个独特的视角,强调能源之间的错综复杂的相互作用,膳食蛋白质,和氨基酸组成,强调他们在健康相关考虑方面的相互依赖。能量和蛋白质合成是生物过程的基础,对生命的维持和生物体的生长至关重要。
    结果:我们探索了能量代谢之间的复杂关系,蛋白质合成,监管机制,蛋白质来源,氨基酸可用性,和自噬,以阐明这些元素如何共同维持细胞稳态。我们强调了这种动态的相互作用在保护细胞生命方面的重要作用。
    结论:更深入地了解能量与蛋白质合成之间的联系对于理解基本的细胞过程至关重要。这种见解可能会在几个医学领域产生广泛的影响,比如营养,新陈代谢,和疾病管理。
    OBJECTIVE: This paper aims to present a unique perspective that emphasizes the intricate interplay between energy, dietary proteins, and amino acid composition, underscoring their mutual dependence for health-related considerations. Energy and protein synthesis are fundamental to biological processes, crucial for the sustenance of life and the growth of organisms.
    RESULTS: We explore the intricate relationship between energy metabolism, protein synthesis, regulatory mechanisms, protein sources, amino acid availability, and autophagy in order to elucidate how these elements collectively maintain cellular homeostasis. We underscore the vital role this dynamic interplay has in preserving cell life.
    CONCLUSIONS: A deeper understanding of the link between energy and protein synthesis is essential to comprehend fundamental cellular processes. This insight could have a wide-ranging impact in several medical fields, such as nutrition, metabolism, and disease management.
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  • 文章类型: Introductory Journal Article
    本文是对“不断变化的价值和能源系统”主题集合的介绍,其中包括六个贡献,这些贡献检查了有关设计的价值变化实例,能源系统的使用和操作。本引言讨论了在能源转型中考虑价值的必要性。它研究了价值和价值变化的概念,以及如何在能源系统的设计中解决价值。能源和能源系统背景下的价值变化是一个最近获得关注的话题。Current,过去,能量转换通常集中在有限范围的值上,比如可持续性,在留下其他突出价值的同时,比如能源民主,或者能源正义,从图片中。此外,这些价值观在这些系统的设计中根深蒂固:利益相关者很难在这些系统的使用和操作中解决新的关切和价值观,导致进一步昂贵的过渡和系统大修。为了解决这个问题,需要更好地理解能源系统背景下的价值变化。我们还需要考虑对治理的进一步要求,能源系统的机构和工程设计,以适应未来的价值变化。开放,透明度,适应性,灵活性和模块化是当前能源转型中的新要求,需要进一步探索和审查。
    This paper is the introduction to a topical collection on \"Changing Values and Energy Systems\" that consists of six contributions that examine instances of value change regarding the design, use and operation of energy systems. This introduction discusses the need to consider values in the energy transition. It examines conceptions of value and value change and how values can be addressed in the design of energy systems. Value change in the context of energy and energy systems is a topic that has recently gained traction. Current, and past, energy transitions often focus on a limited range of values, such as sustainability, while leaving other salient values, such as energy democracy, or energy justice, out of the picture. Furthermore, these values become entrenched in the design of these systems: it is hard for stakeholders to address new concerns and values in the use and operation of these systems, leading to further costly transitions and systems\' overhaul. To remedy this issue, value change in the context of energy systems needs to be better understood. We also need to think about further requirements for the governance, institutional and engineering design of energy systems to accommodate future value change. Openness, transparency, adaptiveness, flexibility and modularity emerge as new requirements within the current energy transition that need further exploration and scrutiny.
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  • 文章类型: News
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  • 文章类型: Letter
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  • 文章类型: Journal Article
    褪黑素是一种强大的内源性抗氧化激素。已在病理条件下报道了其对能量平衡和与氧化代谢紊乱相关的神经元损伤的愈合作用。我们的目的是确定褪黑素对神经元损伤的效用,突触传递,LPS诱导脓毒症大鼠脑组织能量平衡。大鼠分为对照组等四组,LPS(20mg/kgi.p.),褪黑激素(10mg/kg腹膜内注射×3),和LPS+褪黑素(LPS+Mel)。从第一次注射开始6小时后,老鼠被斩首,并采集组织和血清样本。从所有组的血清中确定脂质过氧化和神经元特异性烯醇化酶(NSE)水平。高能化合物,肌酸,和磷酸肌酸通过HPLC方法从匀浆组织中测量。活神经元计数用NeuN(神经元核)标记,用S100-β标记退化的神经元,用突触素抗体免疫反应性分析突触小泡传递。采用单因素方差分析和事后Tukey检验进行统计分析。LPS组,AMP,ATP,肌酸,磷酸肌酸水平显著下降(p<0.05),与其他组相比,ADP水平也显着升高(p<0.01)。LPS组存活神经元计数显著降低(p<0.01),褪黑激素,和LPS+褪黑素组(p<0.05)与对照组相比。与对照组相比,LPS组的变性神经元计数增加(p<0.01),而褪黑素和LPS褪黑素组的变性神经元计数也降低(p<0.01)。与其他组相比,LPS组的突触素免疫反应性降低(p<0.05)。我们观察到褪黑激素的给药可以防止神经元损伤,调节能量代谢,并保护突触囊泡蛋白免受脓毒症诱导的还原。
    Melatonin is a powerful endogenous antioxidant hormone. Its healing effects on energy balance and neuronal damage associated with oxidative metabolism disorders have been reported in pathologic conditions. We aimed to determinate the utility of melatonin on neuronal damage, synaptic transmission, and energy balance in the brain tissue of rats with sepsis induced with LPS. Rats was divided into four groups such as control, LPS (20 mg/kg i.p.), melatonin (10 mg/kg i.p. × 3), and LPS + Melatonin (LPS + Mel). After 6 h from the first injection, rats were decapitated, and also tissue and serum samples were taken. Lipid peroxidation and neuron-specific enolase (NSE) levels were determined from the serum in all group. High energy compounds, creatine, and creatine phosphate are measured by HPLC methods from the homogenized tissue. Counts of living neurons are marked with NeuN (neuronal nuclei), degenerated neurons are marked with S100-ß and synaptic vesicles transmission is analyzed with synaptophysin antibodies immunoreactivities. One-way ANOVA and post hoc Tukey tests were used to statistical analysis. In LPS group, AMP, ATP, creatine, and creatine phosphate levels were significantly decreased (p < 0.05), and also ADP levels were significantly increased compared with the other groups (p < 0.01). Living neurons counts were significantly decreased in LPS (p < 0.01), melatonin, and LPS + Melatonin (p < 0.05) groups compared with control. Degenerated neurons counts were increased in LPS group compared with control (p < 0.01) and also decreased in both of melatonin and LPS + Melatonin groups (p < 0.01). Synaptophysin immunoreactivity was decreased in LPS group compared with the other groups (p < 0.05). We observed that melatonin administration prevents neuronal damage, regulates energy metabolism, and protects synaptic vesicle proteins from sepsis-induced reduction.
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