目的:近年来,FLASH或超高剂量率(UHDR)放射治疗(RT)因其在各种临床前试验中相对于常规剂量率(CDR)RT能够节省正常组织的能力而受到关注。然而,由于缺乏能够提供UHDRRT的加速器,因此这种有希望的治疗选择的临床实施受到限制。我们建立了一个接受的框架,调试,电子闪存单元的定期质量保证(QA),并给出了调试实例。
方法:接受协议,调试,和UHDR线性加速器的QA是通过在四个使用不同UHDR设备的临床中心结合和调整标准线性加速器的标准和专业建议来建立的。非标准剂量测定光束参数考虑包括脉冲宽度,脉冲重复频率,每个脉冲的剂量,和瞬时剂量率,以及如何获得这些测量的建议。
结果:使用此开发的协议调试UHDR电子设备的6和9MeV光束。测量是用离子室的组合获得的,束流互感器(BCT),和剂量率独立的被动剂量计。使用参考设置根据冗余剂量测定的概念校准该单元。
结论:本研究为验收测试提供了详细的建议,调试,低能电子UHDR直线加速器的常规QA。拟议的框架不限于任何特定单位,使其适用于市场上所有现有的eFLASH单元。通过实践见解和理论论述,本文件为临床使用的UHDR设备的调试建立了基准。
UNASSIGNED: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000 Gy/s. We established a framework for the acceptance, commissioning, and periodic quality assurance (QA) of electron FLASH units and present an example of commissioning.
UNASSIGNED: A protocol for acceptance, commissioning, and QA of UHDR linear accelerators was established by combining and adapting standards and professional recommendations for standard linear accelerators based on the experience with UHDR at four clinical centers that use different UHDR devices. Non-standard dosimetric beam parameters considered included pulse width, pulse repetition frequency, dose per pulse, and instantaneous dose rate, together with recommendations on how to acquire these measurements.
UNASSIGNED: The 6- and 9-MeV beams of an UHDR electron device were commissioned by using this developed protocol. Measurements were acquired with a combination of ion chambers, beam current transformers (BCTs), and dose-rate-independent passive dosimeters. The unit was calibrated according to the concept of redundant dosimetry using a reference setup.
UNASSIGNED: This study provides detailed recommendations for the acceptance testing, commissioning, and routine QA of low-energy electron UHDR linear accelerators. The proposed framework is not limited to any specific unit, making it applicable to all existing eFLASH units in the market. Through practical insights and theoretical discourse, this document establishes a benchmark for the commissioning of UHDR devices for clinical use.