■中风是全球死亡的第二大原因。卒中后癫痫(PSS)可导致持续的并发症,比如长期住院,残疾率增加,和更高的死亡率。我们的研究调查了导致当地三级医院患者中风后癫痫发作的相关因素。
■我们设计了一项病例对照研究,在同意的情况下招募接受PSS治疗的患者。然后纳入未发作的中风对照组。在记录其社会人口统计学和临床数据之前,确保基于排除标准的适宜性。在分析数据之前,由两名经认证的神经科医生进行EEG并阅读。
■我们招募了180名参与者,90例和90个匹配的对照。性别(p=0.013),种族(p=0.015),血脂异常(p<0.001),在先行程(p<0.031),大动脉粥样硬化(p<0.001),小血管闭塞(p<0.001),出现时的血压(p<0.028)和溶栓治疗(p<0.029)与PSS的发生显着相关。在男性中观察到PSS的几率增加(1.974),血脂异常(3.480),小血管闭塞(4.578),以及脑电图上有癫痫样改变的参与者(3.630)。相反,在出现高血压的参与者中观察到较低的PSS几率(0.505),大动脉粥样硬化(0.266),以及接受溶栓治疗的患者(0.319)。
■这项研究强调,脑电图和识别高危人群可能有助于识别中风后癫痫发作,其中包括亚洲华裔男性,血脂异常,小血管闭塞,那些血压低到正常的人,和脑电图的癫痫样变化。
该研究旨在确定亚洲人群中与卒中后癫痫发作相关的危险因素及其与西方文献的相似性。我们的发现强调了在高危患者中识别的关键风险因素,这可能会促使将来指南发生变化,以提高患者的预后并提高护理质量。
UNASSIGNED: Stroke is the second leading cause of global deaths. Post-stroke seizures (PSS) can lead to lasting complications, such as prolonged hospitalizations, increased disability rates, and higher mortality. Our study investigates the associated factors that contribute to post-stroke seizures in patients at a local tertiary hospital.
UNASSIGNED: We designed a case-control study where patients admitted with PSS were recruited with consent. Controls admitted for stroke without seizure were then included. Suitability based on exclusion criteria was ensured before recording their sociodemographic and clinical data. An EEG was performed and read by two certified neurologists before the data was analyzed.
UNASSIGNED: We recruited 180 participants, 90 cases and 90 matched controls. Gender (p=0.013), race (p=0.015), dyslipidemia (p<0.001), prior stroke (p<0.031), large artery atherosclerosis (p<0.001), small vessel occlusions (p<0.001), blood pressure on presentation (p<0.028) and thrombolysis administration (p<0.029) were significantly associated with the occurrence of PSS. An increase in odds of PSS was observed in the male gender (1.974), dyslipidemia (3.480), small vessel occlusions (4.578), and in participants with epileptiform changes on EEG (3.630). Conversely, lower odds of PSS were seen in participants with high blood pressure on presentation (0.505), large artery atherosclerosis (0.266), and those who underwent thrombolysis (0.319).
UNASSIGNED: This study emphasized that identifying post-stroke seizures may be aided by EEGs and recognizing at-risk groups, which include males of Chinese descent in Asia, dyslipidemia, small vessel occlusions, those with low to normal blood pressure on presentation, and epileptiform changes in EEGs.
The research aims to establish the risk factors associated with post-stroke seizures in an Asian population and their similarity to the Western literature. Our findings highlight the critical risk factors to identify in at-risk patients, which may prompt changes in guidelines in future to enhance patient outcomes and improve the quality of care.