背景:日本血吸虫与人类结直肠癌之间的关联由来已久;然而,这种联系仍然缺乏研究,缺乏全面的实验支持。
目的:各种流行病学和病理学研究已经确立了慢性炎症作为诱导结直肠癌的主要因素的作用。这篇综述的目的是介绍日本血吸虫与结直肠癌的相关性。
结果:导致结直肠癌诱导和进展的机制以及其诊断和治疗被强调。Further,各种方法,包括大规模药物管理,使用新药和疫苗,凋亡的作用,和组蛋白修饰酶,已经描述了可以预防血吸虫感染本身或可以检查它达到晚期。
结论:流行病学,临床,病理和手术研究表明,日本血吸虫是引起结直肠癌的原因。然而,需要全面的临床研究来支持和全球接受这一观点.Further,可以采用这项工作中强调的方法来治疗血吸虫感染或解决癌症的诱导和进展。
BACKGROUND: An association between Schistosoma japonicum and colorectal cancer in humans has been known since a long time; however, this association remains understudied and lacks comprehensive experimentation support.
OBJECTIVE: Various epidemiological and pathological studies have established the role of chronic inflammation as a major factor behind the induction of colorectal cancer. The aim of this review is to present the current knowledge on the association of Schistosoma japonicum with colorectal cancer.
RESULTS: Mechanisms which lead to induction and progression of colorectal cancer are highlighted along with diagnosis and treatment for the same. Further, various methodologies, including mass drug administration, use of new drugs and vaccines, role of apoptosis, and histone-modifying enzymes, have been described which can either prevent the schistosomal infection itself or can check it from reaching an advanced stage.
CONCLUSIONS: Epidemiological, clinical, pathological and surgical studies suggest that Schistosoma japonicum is responsible for induction of colorectal cancer. However, thorough clinical studies are required to support and globally accept this notion. Further, methodologies highlighted in this work can be employed in order to take care of schistosomal infection or address the cancer induction and progression.