■在受教育程度高的个人中,中等至剧烈的体力活动(MVPA)通常会升高,然而,因果方向和认知表现在这种关联中的作用仍然不明确.在这里,孟德尔随机化(MR)被用来衡量教育之间的因果关系,认知表现,和中等到剧烈的体力活动。这项研究的目的是分析受教育程度对中等至剧烈体育锻炼(MVPA)水平的因果影响,并探索潜在的中介因素。
■进行了双样本单变量MR分析,以评估教育对中度至重度体育锻炼的总体影响。此外,进行了两步MR分析,以评估认知表现对教育对中度至重度体力活动影响的中介作用.包括在内的个人完全是欧洲血统,从广泛的全基因组关联研究(GWAS)收集的关于教育的数据(n=470,941),认知表现(n=257,841),和中等至剧烈的体力活动(MVPA)(n=377,234)。受教育程度以大学毕业身份衡量。认知表现不仅包括心理运动速度,记忆,和抽象推理能力,以及在专业领域获得的知识和技能。MVPA被定义为产生≥3.0的代谢当量(MET)的任何身体活动。
■双样本MR阳性分析表明,教育水平对MVPA缺乏具有显着的保护作用(β=-0.276,95%CI=-0.354至-0.199,p=2.866×10-12)。然而,反向两样本MR分析显示,MVPA与教育水平无显著因果关系(p=0.165).随后,两步MR分析显示,教育对MVPA缺乏风险的潜在因果保护作用主要由认知表现介导(中介效应β=-0.235,95%CI=-0.434~-0.036,中介率为85.061%).
■认知表现在教育水平与MVPA之间的关系中具有重要意义。因此,认知表现的干预可以大大提高教育导致的身体不活动的风险,从而促进个人健康。
UNASSIGNED: In individuals with high educational levels, moderate to vigorous physical activity (MVPA) is often elevated, yet the causal direction and the role of cognitive performance in this association remain ambiguous. Herein, Mendel randomization (MR) was employed to measure the causal relationship between education, cognitive performance, and moderate to vigorous physical activity. The purpose of this study was to analyze the causal effects of educational attainment on moderate-to-vigorous physical activity (MVPA) levels and to explore potential mediating factors.
UNASSIGNED: Two-sample univariate MR analysis was conducted to assess the overall effect of education on moderate to severe physical activity. Besides, a two-step MR analysis was carried out to evaluate the mediating effect of cognitive performance on the impact of education on moderate to severe physical activity. Individuals included were exclusively of European ancestry, with data gathered from extensive genome-wide association studies (GWAS) on education (n = 470,941), cognitive performance (n = 257,841), and moderate-to-vigorous physical activity (MVPA) (n = 377,234). Educational attainment was measured by college graduation status. Cognitive performance encompasses not only psycho-motor speed, memory, and abstract reasoning abilities but also knowledge and skills acquired in professional domains. MVPA is defined as any physical activity that produces a metabolic equivalent (MET) of ≥3.0.
UNASSIGNED: The positive two-sample MR analysis showed that education level had a significant protective effect on MVPA deficiency (β = -0.276, 95% CI = -0.354 to -0.199, p = 2.866 × 10-12). However, the reverse two-sample MR analysis showed that MVPA had no significant causal relationship with education level (p = 0.165). Subsequently, the two-step MR analysis indicated that the potential causal protective effect of education on the risk of MVPA deficiency was mostly mediated by cognitive performance (mediating effect β = -0.235, 95% CI = -0.434 to -0.036, and the intermediary ratio was 85.061%).
UNASSIGNED: Cognitive performance holds considerable significance in the relationship between education level and MVPA. Consequently, the intervention of cognitive performance may greatly improve the risk of physical inactivity caused by education, thereby promoting individual health.