全球2型糖尿病(T2DM)及其并发症患病率的增加对公共卫生提出了重大挑战。最近,碘代偿期疾病(PD)被认为是可能影响T2DM及其并发症进展的因素,因为其可能加剧全身炎症和氧化应激.在这篇社论中，我们评论了ThazhePoyil等人在2024年最近一期的《世界糖尿病杂志》上发表的文章，该文章研究了T2DM患者中PD与糖尿病视网膜病变（DR）之间的相关性，强调牙周肿胀表面积之间的关联，糖化血红蛋白（HbA1c），白细胞介素-6（IL-6），和脂蛋白(a)。ThazhePoyil等人的发现具有重要意义，因为他们证明了T2DM患者中PD和DR之间的紧密联系。这种相关性突出了在糖尿病管理中解决牙周健康问题的重要性，以潜在地降低DR的风险和严重程度。糖尿病的并发症.将牙周评估和治疗整合到糖尿病护理方案中可以改善T2DM患者的血糖控制和更好的总体预后。一些研究已经建立了PD和糖尿病并发症之间的联系，特别是DR,在T2DM患者中，我们旨在在这篇社论中强调这一点。重点放在表明PD和T2DM之间存在双向关系的不同机制上，其中牙周炎症的存在对血糖控制产生负面影响，并通过共同的炎症和血管机制促进DR的发展和进展。这篇文章强调了糖尿病专家之间合作的重要性，眼科医生,牙周病医生,和公共卫生专业人员推进预防，早期发现,以及PD和DR的治疗。这将改善T2DM患者的健康和生活质量。此外，社论强调需要进一步研究牙周炎和DR之间联系的特定分子和免疫机制，鉴定常见的炎症生物标志物和信号通路。这有望促进治疗目标的有效方向，从而通过结合口腔健康的综合护理改善糖尿病及其并发症的管理。
The global increase in the prevalence of type 2 diabetes mellitus (T2DM) and its complications presents significant challenges to public health. Recently, per-iodontal disease (PD) was recognized as a factor that is likely to influence the progression of T2DM and its complications due to its potential to exacerbate systemic inflammation and oxidative stress. In this
editorial, we comment on the article published by Thazhe Poyil et al in the very recent issue of the World Journal of Diabetes in 2024, which investigated the correlation between PD and diabetic retinopathy (DR) in T2DM patients, with emphasis on the association between periodontal swollen surface area, glycated hemoglobin (HbA1c), interleukin-6 (IL-6), and lipoprotein (a). The findings by Thazhe Poyil et al are significant as they demonstrate a strong link between PD and DR in T2DM patients. This correlation highlights the importance of addressing periodontal health in diabetes management to potentially reduce the risk and severity of DR, a complication of diabetes. The integration of periodontal evaluation and treatment into diabetes care protocols may lead to improved glycemic control and better overall outcomes for T2DM patients . A few studies have established an interconnection between PD and diabetic complication, specifically DR, in T2DM patients, which we aim to highlight in this
editorial. Emphasis was placed on the different mechanisms that suggest a bidirectional relationship between PD and T2DM, where the presence of periodontal inflammation negatively influenced glycemic control and contributed to the development and progression of DR through shared inflammatory and vascular mechanisms. This article highlights the importance of collaboration amongst diabetes specialists, ophthalmologists, periodontists, and public health professionals to advance the prevention, early detection, and treatment of PD and DR. This will improve the health and quality of life of T2DM patients. Moreover, the
editorial highlights the need for further research on the specific molecular and immunological mechanisms that underlie the link between periodontitis and DR, with identification of common inflammatory biomarkers and signaling pathways. This is expected to facilitate effective direction of therapeutic objectives, thereby improving the management of diabetes and its complications through integrated care that incorporates oral health.
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