未经证实:开颅手术后疼痛经常被忽视和治疗不足。已经使用了各种类型的镇痛药物,不是没有限制。因此,我们计划研究通过手术引流滴注罗哌卡因的新技术,以研究其对开颅手术后疼痛的影响,术后镇痛需求以及患者的恢复情况和副作用。
未经批准:此预期,随机化,安慰剂对照,双盲研究纳入了50名不同性别的患者,计划接受选择性开颅手术,在全身麻醉下。随机分为两组,分别给予0.25%罗哌卡因12ml(R组)或生理盐水12ml(NS组),穿过水下排水沟,在dura关闭后。在术后1、2、4、8和24小时评估疼痛评分。采用t检验比较连续变量,采用卡方检验或Fisher精确检验比较名义分类数据。
UNASSIGNED:NS组视觉模拟评分高于R组,术后0、1、2小时差异有统计学意义(P=0.012、0.016、0.005,分别)。两组的平均出现时间差异为1.12分钟(P=0.024)。
UNASSIGNED:在伤口闭合期间通过手术(皮下)引流一次性滴注罗哌卡因(12ml,0.25%)是一种有效且简单的技术,可以减少术后疼痛和镇痛剂消耗以及早期出现在神经外科手术患者中。
UNASSIGNED: Post-craniotomy pain has often been overlooked and undertreated. Various classes of analgesic drugs have been used, not without limitations. Therefore, we planned to study the novel technique of wound instillation of ropivacaine through the surgical drain in patients undergoing supratentorial craniotomy to study its effect on post-craniotomy pain, analgesic requirement in the post-operative period along with the recovery profile of the patient and the side effects.
UNASSIGNED: This prospective, randomised, placebo-controlled, double-blinded study enroled 50 patients of either gender, scheduled to undergo elective craniotomy, under general anaesthesia. They were randomly divided into two groups and received either 12 ml of 0.25% ropivacaine (group R) or 12 ml of normal saline (group NS), through the subgaleal drain, after the closure of the dura. Pain scores were assessed at 1, 2, 4, 8 and 24 hours post-operatively. Student\'s t-test was used for comparison of continuous variables and the Chi-square test or Fisher\'s exact test was used for comparing the nominal categorical data.
UNASSIGNED: The visual analogue scale score was higher in group NS than in group R, and the difference was statistically significant (P = 0.012, 0.016, and 0.005 at 0, 1, and 2 post-operative hours, respectively). The difference in the mean emergence time in the two groups was 1.12 minutes (P = 0.024).
UNASSIGNED: Single-time wound instillation of ropivacaine (12 ml of 0.25%) through surgical (subgaleal) drain during wound closure is an effective and simple technique for reducing post-operative pain and analgesic consumption and early emergence in neurosurgical patients undergoing supratentorial craniotomy.