■青春期是患抑郁症风险增加的时期,也是自我认同发展和整合的关键时期。尽管如此,自我参照加工的神经生理学相关性与青年抑郁症状之间的关系尚不清楚。这里,我们利用自参考编码任务(SRET)的计算模型来识别后验晚期正电位(LPP)之间关联的行为调节者,与情绪调节相关的事件相关电位,和青少年自我报告的抑郁症状。具体来说,在漂移扩散框架内,我们评估了后部LPP与青年抑郁症症状之间的关联是否通过漂移率调节,反映自我评估决策过程中处理效率的参数。
■106名青少年的样本,12至17岁(53%为男性;法师=14.49,标准差=1.70),同时进行高密度脑电图和抑郁和焦虑的自我报告测量,完成了SRET。
■研究结果表明有明显的节制:对于年轻人,与积极的单词相比,在对负面单词做出反应时表现出更高的处理效率(漂移率),较大的后部LPP预测抑郁症状严重程度。
■我们依靠社区样本,我们的研究本质上是横断面的。未来对临床抑郁青年的纵向工作将是有益的。
■我们的研究结果表明了青少年抑郁症的神经行为模型,其中负面信息的有效处理与对情感自我调节的需求增加同时发生。我们的发现也具有临床相关性;青年的神经生理反应(后LPP)和在SRET期间的表现可能作为追踪治疗相关的自我认同变化的新目标。
UNASSIGNED: Adolescence is a time of heightened risk for developing depression and also a critical period for the development and integration of self-identity. Despite this, the relation between the neurophysiological correlates of self-referential processing and major depressive symptoms in youth is not well understood. Here, we leverage computational modeling of the self-referential encoding task (SRET) to identify behavioral moderators of the association between the posterior late positive potential (LPP), an event-related potential associated with emotion regulation, and youth self-reported symptoms of depression. Specifically, within a drift-diffusion framework, we evaluated whether the association between the posterior LPP and youth symptoms of major depression was moderated by drift rate, a parameter reflecting processing efficiency during self-evaluative decisions.
UNASSIGNED: A sample of 106 adolescents, aged 12 to 17 (53% male; Mage = 14.49, SD = 1.70), completed the SRET with concurrent high-density electroencephalography and self-report measures of depression and anxiety.
UNASSIGNED: Findings indicated a significant moderation: for youth showing greater processing efficiency (drift rate) when responding to negative compared to positive words, larger posterior LPPs predicted greater depressive symptom severity.
UNASSIGNED: We relied on a community sample and our study was cross-sectional in nature. Future longitudinal work with clinically depressed youth would be beneficial.
UNASSIGNED: Our results suggest a neurobehavioral model of adolescent depression wherein efficient processing of negative information co-occurs with increased demands on affective self-regulation. Our findings also have clinical relevance; youth\'s neurophysiological response (posterior LPP) and performance during the SRET may serve as a novel target for tracking treatment-related changes in one\'s self-identity.