■这项研究的目的是调查人口统计学和剂量学参数,这些参数可能与接受锁骨上窝三维适形放疗的乳腺癌患者的食管炎有关。
■我们检查了27例锁骨上转移的乳腺癌患者。所有患者均接受规定剂量为40.5Gy的放射治疗(RT),分15次进行3周。每周记录食管炎,并根据肿瘤治疗组评估和分级食道毒性。通过单变量和多变量分析检查了以下因素与1级或更严重的食管炎的相关性:年龄,化疗,吸烟史,最大剂量(Dmax),平均剂量(Dmean),食道容积接受10Gy(V10),食道容积接受20Gy(V20),和食管的长度在治疗领域。
■27,11(40.7%)患者在整个治疗过程中没有出现食道刺激。大约一半的患者13/27(48.1%)患有最大1级食管炎。2/27(7.4%)患者有2级食管炎。3级食管炎的发生率为(3.7%)。Dmean,Dmax,V10和V20为10.48±5.10Gy,38.18±5.12Gy,分别为29.83±15.16和19.32±10.01。我们的结果显示Dmean,V10和V20是发生食管炎的重要因素,而食管炎与化疗方案无关,年龄,和吸烟状况。
■我们发现Dmean,V10和V20与急性食管炎显著相关。然而,化疗方案,年龄,吸烟状况不影响食管炎的发展。
UNASSIGNED: The aim of this study was to investigate demographic and dosimetric parameters which may link with esophagitis in patients with breast cancer receiving three-dimensional conformal radiotherapy to the supraclavicular fossa.
UNASSIGNED: We examined 27 breast cancer patients with supraclavicular metastases. All patients were treated with radiotherapy (RT) with a prescribed dose of 40.5 Gy in 15 fractions for 3 weeks. Esophagitis was recorded weekly and esophagus toxicity was evaluated and graded according to the tadiation therapy oncology group. The following factors were examined regarding their correlation with grade 1 or worse esophagitis by univariate and multivariate analyses: age, chemotherapy, smoking history, maximum dose (Dmax), mean dose (Dmean), esophagus volume receiving 10 Gy (V10), esophagus volume receiving 20 Gy (V20), and length of esophagus in the treatment field.
UNASSIGNED: Of 27, 11 (40.7%) patients developed no esophageal irritation throughout therapy. Approximately half of the patients 13/27 (48.1%) had maximum grade 1 esophagitis. 2/27 (7.4%) patients had grade 2 esophagitis. The incidence of grade 3 esophagitis was (3.7%). Dmean, Dmax, V10, and V20 were 10.48 ± 5.10 Gy, 38.18 ± 5.12Gy, 29.83 ± 15.16, and 19.32 ± 10.01, respectively. Our results showed that Dmean, V10, and V20 were the significant factors for the development of esophagitis, whereas esophagitis was not significantly associated with the chemotherapy regimen, age, and smoking status.
UNASSIGNED: We found that Dmean, V10, and V20 correlated significantly with acute esophagitis. However, the chemotherapy regimen, age, and smoking status did not affect esophagitis development.