药物相关性肾损伤与住院时间延长、慢性肾脏病风险增加和死亡率增加有关。然而,目前缺乏关于儿童药物相关肾损伤的大人群研究.本研究旨在研究进行数据挖掘以产生关于药物的假设,这可能值得根据其增加儿童肾损伤的潜在风险进行评估。我们在FDA不良事件报告系统(FAERS)中提取并分析了与儿童肾损伤相关的药物报告。我们使用比例报告比(PRR)进行了不成比例分析,以评估药物与儿童肾损伤之间的关系。同时,与药物标签进行比较,以确定药物,尽管目前在他们的标签中没有提到肾损伤,可能与儿童肾损伤的风险有关。在FAERS数据库中,共有6347名儿童患有药物相关的肾损伤。PRR最高的前五名药物为庆大霉素(PRR=12.28,N=157例,卡方=1602.77),哌拉西林他唑巴坦(PRR=9.77,N=129例,卡方=1003.24),氨氯地平(PRR=8.98,N=271例,卡方=1861.46),万古霉素(PRR=8.91,N=295例,卡方=1998.64),头孢曲松(PRR=8.00,N=251例,卡方=1494.02)。根据药品标签,9种药物(9/30)被归类为潜在的肾毒素。
结论:大约三分之一与儿童肾损伤相关的药物在其药物标签中没有将肾损伤列为副作用。因此,未来的研究有必要评估这些药物是否与这种风险相关。
背景:•肾毒性药物日益成为住院儿童急性肾损伤的常见原因。•目前,没有研究系统梳理与儿童肾损伤相关的药物。
背景:•在数据挖掘中显示儿童潜在肾损伤信号的药物中约有三分之一没有在其药物标签中提及这种副作用。本研究提供了需要进一步研究的药物数据,以确定它们是否可能增加儿童肾损伤的风险。
Drug-associated kidney injury is related to longer hospitalization and increased risk of chronic kidney disease and mortality. However, there is currently a lack of large population studies on drug-associated kidney injury in children. This study aimed to study perform data mining to generate hypotheses on drugs, which may deserve to be assessed as per their potential risk of increasing kidney injury in children. We extracted and analyzed reports on drugs associated with kidney injury in children in the FDA Adverse Event Reporting System (FAERS). We conducted a
disproportionality analysis using proportional reporting ratio (PRR) to evaluate the association between drugs and kidney injury in children. Meanwhile, comparisons were performed with drug labels to identify drugs that, despite not having kidney injury currently mentioned in their labels, may potentially be associated with risks of kidney injury in children. A total of 6347 children had drug-associated kidney injury in the FAERS database. The top five drugs with the highest PRR were gentamicin (PRR = 12.28, N = 157 cases, Chi-Squared = 1602.77), piperacillin-tazobactam (PRR = 9.77, N = 129 cases, Chi-Squared = 1003.24), amlodipine (PRR = 8.98, N = 271 cases, Chi-Squared = 1861.46), vancomycin (PRR = 8.91, N = 295 cases, Chi-Squared = 1998.64), and ceftriaxone (PRR = 8.00, N = 251 cases, Chi-Squared = 1494.02). According to drug labels, 9 drugs (9/30) were classified as potential nephrotoxins.
CONCLUSIONS: Approximately one-third of drugs associated with kidney injury in children do not list kidney injury as a side effect in their drug labels. Future studies are therefore warranted to evaluate whether these drugs are associated with such a risk.
BACKGROUND: • Nephrotoxic drugs are an increasingly common cause of acute kidney injury in hospitalized children. • Currently, no study has systematically combed drugs associated with kidney injury in children.
BACKGROUND: • Approximately a third of drugs showing signals for potential kidney injury in children in data mining do not mention this side effect in their drug labels. • This study provides data on drugs needing further study to determine whether they might increase the risk of kidney injury in children.