目的:总结近年来非编码RNA(ncRNAs)在食管鳞状细胞癌(ESCC)中的研究进展及研究热点,并展望未来的研究方向。方法:直到2023年10月31日,从WebofScience获得了相关文章。使用软件(VOSviewer,CiteSpace,和Bibliometrix)。出版物的数量和引用,以及国家,机构,作者,journal,以文章关键词为变量,分析研究趋势和热点演变。结果:从数据库中检索到2008年至2023年的1,118篇文献,有25个国家/地区,793个机构,5,426名作者,涉及261种期刊。全球合作以中国为中心,Japan,和美国。郑州大学,一个来自中国的机构,有最高的出版物。最多产的作者是郭伟,最多产的杂志是《肿瘤学快报》。对关键词的分析显示,该领域的研究围绕ncRNAs在其发生中的作用,发展,诊断,治疗,和ESCC的预后,主要包括微小RNA,长链非编码RNA,然后是环状RNA。结论:总体而言,关于ESCC中ncRNAs的研究仍然很强大。以往的研究主要集中在基础研究上,关注ncRNAs的发生机制,发展,诊断,治疗,和ESCC的预后。将当前研究与新兴学科相结合,进一步探讨其作用机制或将研究重点从临床前研究转向以诊断为基础的临床研究,治疗,和预后,将是未来该领域的主要突破。
Objectives: Summarize the progress and hot topic evolution of non-coding RNAs (ncRNAs) research in esophageal squamous cell carcinoma (ESCC) in recent years and predict future research directions. Methods: Relevant articles from the Web of Science until 31 October 2023 were obtained. Bibliometric analysis of included articles was performed using software (VOSviewer, CiteSpace, and Bibliometrix). The volume and citation of publications, as well as the country, institution, author, journal, keywords of the articles were used as variables to analyze the research trends and hot spot evolution. Results: 1,118 literature from 2008 to 2023 were retrieved from database, with 25 countries/regions, 793 institutions, 5,426 authors, 261 journals involved. Global cooperation was centered on China, Japan, and the United States. Zhengzhou University, an institution from China, had the highest publication. The most prolific author was Guo Wei, and the most prolific journal was Oncology Letters. Analysis of keywords revealed that the research in this field revolved around the role of ncRNAs in the occurrence, development, diagnosis, treatment, and prognosis of ESCC, mainly including micro RNAs, long non-coding RNAs, and then circular RNAs. Conclusion: Overall, research on ncRNAs in ESCC remains strong. Previous research has mainly focused on the basic research, with a focus on the mechanism of ncRNAs in the occurrence, development, diagnosis, treatment, and prognosis of ESCC. Combining current research with emerging disciplines to further explore its mechanisms of action or shifting the focus of research from preclinical research to clinical research based on diagnosis, treatment, and prognosis, will be the main breakthrough in this field in the future.