膳食钠摄入量(DSI)、膳食钾摄入量(DPI),肾结石病(KSD)尚不清楚。我们检查了2011-2018年全国健康和营养检查调查,以确定每日DSI之间的独立关联,DPI,DSI/DPI,和KSD患病率。总的来说,19,405名参与者被纳入分析,其中1895人有KSD。当将DSI建模为连续变量时,较高的DSI与回归分析中KSD的几率无关(OR=0.99,95%CI:0.99-1.00,p=0.2),或将DSI的最高四分位数与最低四分位数进行比较(OR=0.84,95%CI:0.68-1.04,p=0.1)。与DSI不同,当将DPI建模为连续变量时,较高的DPI与回归分析中KSD的几率降低密切相关(OR=0.99,95%CI:0.99-0.99,p=0.02),或将DPI的最高四分位数与最低四分位数进行比较(OR=0.75,95%CI:0.60-0.94,p=0.01)。最后,当将DSI/DPI建模为连续变量时,较高的DSI/DPI也与回归分析中KSD的几率增加密切相关(OR=1.1,95%CI:1.01-1.20,p=0.03),或将DPI的最高四分位数与最低四分位数进行比较(OR=1.30,95%CI:1.10-1.70,p=0.008)。所有观察到的关系都与总卡路里摄入量无关。总之,较低的DPI和较高的DSI/DPI均与KSD风险增加相关.未来的前瞻性研究需要澄清这些因果关系。
The associations between dietary sodium intake (DSI), dietary potassium intake (DPI), and kidney stone disease (KSD) are not clear. We examined The National Health and Nutrition Examination Survey 2011-2018 to determine the independent associations between daily DSI, DPI, DSI/DPI, and KSD prevalence. In total, 19,405 participants were included for analysis, of which 1,895 had KSD. Higher DSI was not associated with increased odds of KSD in regression analysis when DSI was modeled as a continuous variable (OR = 0.99, 95% CI: 0.99-1.00, p = 0.2), or when comparing highest quartile of DSI to lowest quartile (OR = 0.84, 95% CI: 0.68-1.04, p = 0.1). Unlike DSI, higher DPI was strongly associated with reduced odds of KSD in regression analysis when DPI was modeled as a continuous variable (OR = 0.99, 95% CI: 0.99-0.99, p = 0.02), or when comparing highest quartile of DPI to lowest quartile (OR = 0.75, 95% CI: 0.60-0.94, p = 0.01). Lastly, higher DSI/DPI was also strongly associated with increased odds of KSD in regression analysis when DSI/DPI was modeled as a continuous variable (OR = 1.1, 95% CI: 1.01-1.20, p = 0.03), or when comparing highest quartile of DPI to lowest quartile (OR = 1.30, 95% CI: 1.10-1.70, p = 0.008). All the observed relationships were independent of total calorie intake. In conclusion, both lower DPI and higher DSI/DPI are associated with an increased risk of KSD. Future prospective studies are needed to clarify these causal relationships.