在全球范围内,肥胖被认为是一种慢性和高患病率疾病,影响所有性别和年龄。虽然各种药物已被证实用于治疗肥胖症,这些药物已被证明对健康有许多不利影响。强调天然产物在广泛的疾病中具有缓解作用,特别是肥胖,和糖尿病。山奈酚(KMP),一种来源于植物的黄酮醇,在很大程度上参与抑制氧化应激,自由基清除,相反的细胞毒性,以及诱导生长因子的产生和释放。这种黄酮醇通过抑制脂肪生成来对抗肥胖,调节脂质和葡萄糖代谢,改变肠道微生物群,激活自噬。此外,研究表明,KMP通过减少脂质和甘油三酯(TG)的积累发挥其抗肥胖作用,增加脂肪酸氧化,调节脂肪细胞中的多种代谢基因。考虑到KMP可能是对抗肥胖的潜在候选人,本文总结了KMP在治疗和预防该疾病中可能的治疗作用。
Obesity is considered as a chronic and high-prevalence disease on a global scale which affects all genders and ages. Although various drugs have been confirmed for the treatment of obesity, these medications have been shown to have a number of adverse effects on health. It is highlighted that natural products have an alleviative role in a broad spectrum of diseases, in particular obesity, and diabetes. Kaempferol (KMP), a plant- derived flavonol, is considerably engaged in the suppression of oxidative stress, radical scavenging, opposing cellular toxicity, and induction of the production and release of growth factors. This flavonol combats obesity by suppressing adipogenesis, regulating lipid and glucose metabolism, changing gut microbiota, and activating autophagy. Also, studies have shown that KMP exerts its anti-obesity actions by decreasing the accumulation of lipids and triglycerides (TGs), increasing fatty acid oxidation, and regulating multiple metabolic genes in the adipocytes. Considering that KMP may be a potential candidate for combating obesity, this paper summarizes the possible therapeutic roles of KMP in the treatment and prevention of this disease.