■在2型糖尿病患者中,糖尿病视网膜病变(DR)的发展与血清chemerin水平升高呈正相关。本研究旨在探讨1型糖尿病(T1DM)患者血清chemerin水平与DR发展之间的可能关系。
■在这项横断面研究中,我们纳入了埃及人,并将他们分为四组:第1组,包括健康个体;第2组,包括无DR的T1DM患者;第3组,包括无增殖性DR(NPDR)的T1DM患者;第4组,包括有增殖性DR(PDR)的T1DM患者.评估包括最佳矫正视力评估,裂隙灯生物显微镜,基金副本,荧光素眼底血管造影,和黄斑眼相干断层扫描。从所有参与者获得空腹血样以测量血清chemerin,糖化血红蛋白(HbA1c),总胆固醇,甘油三酯,和肌酐水平。各组之间比较血清chemerin水平,以及它们与年龄的相关性,糖尿病的持续时间,HbA1c,总胆固醇,甘油三酯,和肌酐水平进行了分析。
■我们招募了209名参与者,包括第1组46例健康个体,第2组52例(T1DM和非DR),第3组61例(T1DM和NPDR),第4组50例(T1DM和PDR),组间平均年龄和性别比例相当.糖尿病的持续时间,身体质量指数,HbA1c,总胆固醇,甘油三酯,血清chemerin水平在各组间有显著差异(均P<0.001),而肌酐水平没有(P>0.05)。第4组血清chemerin水平明显高于第3组和第2组,第3组明显高于第2组,第3组和第4组明显高于第1组(均P<0.001)。然而,第1组和第2组具有可比性(P>0.05)。它与T1DM和HbA1c的持续时间相关,总胆固醇,甘油三酯,和肌酐水平,但与年龄无关。
■有DR的T1DM患者的血清chemerin水平高于无DR的T1DM患者或健康个体。PDR患者的血清chemerin水平高于NPDR患者。因此,血清chemerin水平是T1DM患者DR发生和严重程度的潜在生物标志物。然而,未来的诊断准确性研究需要证实这些潜在的应用.
UNASSIGNED: In patients with type 2 diabetes mellitus, the development of diabetic retinopathy (DR) correlates positively with elevated serum chemerin levels. This study was aimed at investigating the probable association between the serum chemerin level and the development of DR in patients with type 1 diabetes mellitus (T1DM).
UNASSIGNED: In this cross-sectional study, we included Egyptians and classified them into four groups: group 1, including healthy individuals; group 2, including patients with T1DM without DR; group 3, including patients with T1DM with non-proliferative DR (NPDR); and group 4, including patients with T1DM with proliferative DR (PDR). The assessment included best-corrected distance visual acuity assessment, slit-lamp biomicroscopy, funduscopy, fundus fluorescein angiography, and macular ocular coherence tomography. Fasting blood samples were obtained from all participants to measure serum chemerin, glycated hemoglobin (HbA1c), total cholesterol, triglyceride, and creatinine levels. Serum chemerin levels were compared among the groups, and their correlations with age, duration of diabetes, HbA1c, total cholesterol, triglyceride, and creatinine levels were analyzed.
UNASSIGNED: We recruited 209 participants, including 46 healthy individuals in group 1, 52 patients (T1DM and no DR) in group 2, 61 patients (T1DM and NPDR) in group 3, and 50 patients (T1DM and PDR) in group 4, with comparable mean ages and sex ratios among groups. The diabetes duration, body mass index, HbA1c, total cholesterol, triglyceride, and serum chemerin levels differed significantly among the groups (all P < 0.001), whereas the creatinine level did not (P > 0.05). The serum chemerin level was significantly higher in group 4 than in groups 3 and 2, in group 3 than in group 2, and in groups 3 and 4 than in group 1 (all P < 0.001). However, it was comparable between groups 1 and 2 (P > 0.05). It correlated with the duration of T1DM and HbA1c, total cholesterol, triglyceride, and creatinine levels but not with age.
UNASSIGNED: Patients with T1DM with DR showed higher serum chemerin levels than those with T1DM without DR or healthy individuals. Serum chemerin levels were higher in those with PDR than in those with NPDR. Thus, serum chemerin levels are a potential biomarker of the development and severity of DR in patients with T1DM. Nevertheless, future diagnostic accuracy studies are required to confirm these potential applications.