■呼出气或汗液中的挥发性有机化合物(VOC)的评估代表了呼吸系统疾病的潜在非侵入性和快速诊断工具。
■确定经过训练的狗是否可以可靠地识别与COVID19相关的气味。
■这是一项从2021年7月至11月在大学医院急诊科(ED)进行的单中心前瞻性研究。所有患者的腋窝汗液样本均由两名训练有素的医疗保健专业人员收集。对于每位患者,以放置在腋下至少4小时的无菌纱布拭子的形式收集样品。然后,两个人将管运送到双盲狗培训中心,以检测VOC。
■使用总共129份腋窝汗液样本对狗进行了测试;根据气味对COVID-19检测呈阳性的107例患者中有69例PCR/抗原检测呈阳性,狗对COVID-19检测呈阴性的22例患者中有19例PCR检测呈阴性。嗅探犬感染检测方法的灵敏度为95.83%,特异性为33.33%。PPV为64.49%,NPV为86.36%。两个变量(疾病/体征)之间的连接强度的测量非常强(Q=0.84)。这种联系具有统计学意义(X2=19.13),概率p≤0.001。
■总的来说,使用经过训练的检测犬作为SARS-CoV-2的筛查方法是一个有趣的研究途径,值得进一步探索和验证.
UNASSIGNED: The assessment of Volatile Organic Compounds (VOCs) in exhaled breath or sweat represents a potential non-invasive and rapid diagnostic tool for respiratory diseases.
UNASSIGNED: To determine if trained dogs can reliably identify the odour associated with COVID19.
UNASSIGNED: This is a monocentric prospective study carried out in the Emergency Department (ED) of a university hospital fromJulyto November 2021.Axillary sweat samples from all patients were collected bytwo trained health care professionals. The samples were collected in the form of sterile gauze swabs placed under the armpits for at least 4 h for each patient.Then, Tubes wereshiftedto the double-blind dog training centre for VOC detection by two individuals.
UNASSIGNED: Dogs were tested using a total of 129 axillary sweat samples; 69 of the 107 patients who tested positive for COVID-19 based on their odours had a positive PCR/Antigen test and 19 of the 22 patients who were tested negative for COVID-19 by the dogs had a negative PCR test. The sniffer dog infection detection method had a sensitivity of 95.83% and a specificity of 33.33%. The PPV was 64.49% and the NPVwas 86.36%. The measurement of the intensity of the connection between the two variables (disease/sign) was very strong (Q = 0.84). This link is statistically significant (X2 = 19.13) with a probability p ≤ 0.001.
UNASSIGNED: Overall, the use of trained detection dogs as a screening method for SARS-CoV-2 is an interesting avenue of research that warrants further exploration and validation.