■精神疾病与牙面畸形之间的关联引起了广泛的关注。然而,他们的关系目前尚不清楚且有争议。
■进行了双样本双向MR分析,以研究牙颌骨畸形与八种精神疾病之间的因果关系,包括重度抑郁症,恐慌症,精神分裂症,双相情感障碍,注意缺陷多动障碍,老年痴呆症,自闭症谱系障碍,和神经质。反向方差加权,加权中位数,MR-Egger回归,加权模式四种方法,并进行了进一步的敏感性分析。
■重度抑郁障碍影响牙面畸形,OR=1.387(95%CI=1.181~1.629,P=6.77×10-5)。没有发现其他精神疾病与牙面畸形有关。反过来,牙面畸形与神经质有关,OR=1.050(95%CI=1.008-1.093,P=0.018)。而且没有证据表明牙面部畸形会增加其他精神疾病的风险。
■重度抑郁症可能会增加牙面畸形的风险,和牙面畸形的状况会增加神经质发病的风险。
UNASSIGNED: The association between psychiatric disorders and dentofacial deformities has attracted widespread attention. However, their relationship is currently unclear and controversial.
UNASSIGNED: A two-sample bidirectional MR analysis was performed to study the causal relationship between dentofacial deformity and eight psychiatric disorders, including major depressive disorder, panic disorder, schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, Alzheimer\'s disease, autism spectrum disorder, and neuroticism. Inverse variance weighted, weighted median, MR-Egger regression, weighted mode four methods, and further sensitivity analyses were conducted.
UNASSIGNED: The major depressive disorder affected dentofacial deformity, with an OR = 1.387 (95% CI = 1.181-1.629, P = 6.77×10-5). No other psychiatric disorders were found to be associated with dentofacial deformity. In turn, dentofacial deformity were associated with neuroticism, with an OR = 1.050 (95% CI = 1.008-1.093, P = 0.018). And there was no evidence that dentofacial deformity would increase the risk of other psychiatric disorders.
UNASSIGNED: Major depressive disorder might elevate the risk of dentofacial deformities, and dentofacial deformity conditions would increase the risk of the incidence of neuroticism.