■与年龄相关的神经元变化会影响认知完整性,这是健康和生活质量的主要贡献者。预防认知功能下降和阿尔茨海默病的最佳策略仍存在争议。
■研究德国认知健康成年人与一般健康咨询(GHC)相比,为期八周的多组分训练计划BrainProtect®对认知能力的长期影响。
■健康成年人(年龄≥50岁)先前随机接受GHC(n=72)或BrainProtect(干预组,IG,n=60)持续八周(每周一次,90分钟,以小组为基础)在干预结束后3个月和12个月接受了全面的神经心理学测验电池和与健康相关的生活质量(HRQoL)评估。
■3个月后的辍学率为n=8,12个月后为n=19。对于建立阿尔茨海默病登记处(CERAD-Plus)总评分的主要终点联盟,未观察到BrainProtect的显著长期效果。与GHC组相比,在IG参与者完成培训计划后12个月,逻辑推理显着改善(p=0.024),年龄,教育,饮食,和身体活动。在IG参与者中,与GHC组相比,完成干预后3个月的思维灵活性(p=0.019)和对抗性命名(p=0.010)得到改善,然而,经过保守的Bonferroni调整,意义丢失了。
■与GHC相比,BrainProtect®在健康成年人的认知训练结束后12个月内独立改善了逻辑推理。揭示多组分认知训练在健康成人中的长期临床意义,样本量较大的研究和频繁的随访是必要的.
UNASSIGNED: Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer\'s disease is still debated.
UNASSIGNED: To investigate the long-term effects of the eight-week multicomponent training program BrainProtect® on cognitive abilities compared to general health counseling (GHC) in cognitively healthy adults in Germany.
UNASSIGNED: Healthy adults (age ≥50 years) previously randomized to either GHC (n = 72) or BrainProtect (intervention group, IG, n = 60) for eight-weeks (once weekly, 90 minutes, group-based) underwent a comprehensive neuropsychological test battery and health-related quality of life (HRQoL) evaluation 3- and 12-months after intervention end.
UNASSIGNED: Dropout rates were n = 8 after 3 months and n = 19 after 12 months. No significant long-term effect of BrainProtect was observed for the primary endpoint Consortium to Establish a Registry for Alzheimer\'s Disease (CERAD-Plus) total score. Logical reasoning was significantly improved (p = 0.024) 12 months after completion of the training program in IG participants compared to the GHC group independent of sex, age, education, diet, and physical activity. In IG participants, thinking flexibility (p = 0.019) and confrontational naming (p = 0.010) were improved 3 months after completing the intervention compared to the GHC group, however, after conservative Bonferroni adjustment, significance was lost.
UNASSIGNED: BrainProtect® independently improved logical reasoning compared to GHC up to 12 months after cognitive training\'s end in healthy adults. To uncover the long-term clinical significance of multicomponent cognitive training in healthy adults, studies with larger sample size and frequent follow up visits are necessary.