四种新化合物,包括一个drimane倍半萜内酯(1),一种异香豆素(2),一种香豆素(3),和一种新的天然产品(4),以及从深海衍生的枝孢菌中获得的14种已知化合物。SCSIO41318.使用广泛的NMR和HRESIMS光谱分析确定了新化合物的结构,电子圆二色性计算,和单晶X射线衍射测量。生物测定表明,化合物(1,6,7,9-12,14,15,17,18)对试验的人病原菌和植物病原真菌均表现出不同程度的抗菌活性。此外,青霉酮A(11)和青霉醇A(12)对22Rv1细胞系显示出弱的抗肿瘤活性。
Four new compounds, including one drimane sesquiterpene lactone (1), one isocoumarin (2), one coumarin (3), and a new natural product (4), as well as fourteen known compounds were obtained from a deep-sea derived Cladosporium sp. SCSIO 41318. The structures of the new compounds were determined using extensive NMR and HRESIMS spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction measurements. Biological assays showed that compounds (1, 6, 7, 9-12, 14, 15, 17, 18) exhibited varying degrees of antimicrobial activity against the tested human pathogenic bacteria and plant pathogenic fungi. Besides, penicitrinone A (11) and penicitrinol A (12) displayed weak antitumor activities against the 22Rv1 cell line.