■尽管有研究表明,产前肥胖升高与后代患各种疾病的风险增加有关,对免疫系统知之甚少。这项研究的目的是评估后代出生后的头10年中,产前肥胖与脐带血中细胞因子水平与过敏性疾病发展之间的关系。
2011年在中国绍兴妇女儿童医院出生的足月婴儿队列纳入本研究。流式细胞术测量各种脐带血细胞因子的水平,即IL1β,IL2、IL10、IL6、IL8、IL17、IL12、TNF-α和IFN-γ。接下来,采用logistic回归分析研究产前BMI与过敏性疾病发生发展的关系。脐带血各细胞因子水平与产前BMI、使用线性和逻辑回归分析测试过敏性疾病的发展,分别。
■经过10年的随访,产前BMI升高与儿童过敏性疾病的发生显著相关(HR=2.45,95%CI:1.08~5.57,P=0.033).我们还调整了产妇年龄,教育和婴儿性别,发现产前BMI与脐带血IL12(P=0.023)和IL1β(P=0.049)水平显著相关。此外,我们调整了产妇年龄,教育,过敏性皮炎,胎龄和婴儿性别,发现IL17中每个单位(1.26pg/ml)的增加与10岁儿童的过敏性疾病风险增加55.5%相关(HR=1.55,95%Cl:0.99-2.45,P=0.056)。同时,在调整了产妇年龄后,教育水平,胎龄,产前BMI,妊娠期体重增加,婴儿性别和出生体重,我们发现,IL10、IL6和IL1β每增加一个单位,10年随访后儿童超重/肥胖的风险增加了18.7%(HR=1.19,95%Cl:1.01-1.40,P=0.042),13.9%(HR=1.14,95%Cl:1.02-1.27,P=0.021)和41.3%(HR=1.41,95%Cl:1.02-1.95,P=0.036),分别。
■产前肥胖与子代过敏性疾病呈正相关。脐血细胞因子可能在产前肥胖与后代过敏性疾病的关系中起中介作用。
UNASSIGNED: Although studies have associated elevated prenatal obesity with increased risk of various diseases in offspring, little is known regarding the immune system. The aim of this study was to evaluate the relationship between prenatal obesity and levels of cytokines in umbilical cord blood and development of allergic disease during the first 10 years of life in an offspring.
UNASSIGNED: A cohort of term infants born at the ShaoXing Women and Children Hospitals in China in 2011 was enrolled in this study. Flow cytometry was performed to measure levels of various cord blood cytokines, namely IL1β, IL2, IL10, IL6, IL8, IL17, IL12, TNF-α and IFN-γ. Next, logistic regression was used to explore the association of prenatal BMI with the development of allergic disease. The relationship between levels of each cord blood cytokine with prenatal BMI, and allergic disease development was tested using linear and logistic regression analyses, respectively.
UNASSIGNED: After 10 years of follow-up, higher prenatal BMI was significantly associated with development of allergic disease in children (HR = 2.45, 95% CI:1.08-5.57, P = 0.033). We also adjusted for maternal age, education and infant gender, and found that prenatal BMI was significantly associated with higher levels of IL12 (P = 0.023) and IL1β (P = 0.049) in cord blood. Moreover, we adjusted for maternal age, education, allergic dermatitis, gestation age and infant gender, and found that increase in each unit (1.26 pg/ml) in IL17 was associated with a 55.5% higher risk of allergic disease in 10-year-old children (HR = 1.55, 95%Cl: 0.99-2.45, P = 0.056). Meanwhile, after adjusting for maternal age, education level, gestation age, prenatal BMI, gestational weight gain, infant gender and birthweight, we found that for every unit increase in IL10, IL6 and IL1β, the risk of overweight/obesity in children after 10-year follow-up increased by 18.7% (HR = 1.19, 95%Cl: 1.01-1.40, P = 0.042), 13.9% (HR = 1.14, 95%Cl: 1.02-1.27, P = 0.021) and 41.3% (HR = 1.41, 95%Cl: 1.02-1.95, P = 0.036), respectively.
UNASSIGNED: Prenatal obesity was positively correlated with allergic diseases in offspring. Cord blood cytokine may play mediating roles in the associations of prenatal obesity with offspring allergic diseases.