■氧化应激可导致多种疾病,并增加先天性心脏病患儿术后并发症的风险。由于这些原因,本研究的目的是探讨紫红色和无紫红色的儿科患者接受心脏手术时氧化应激指标的差异。
■85名患者被纳入研究。对手术前和手术后24小时内采集的样本进行血红蛋白(Hb)评估,白细胞,尿酸,谷胱甘肽(GSH),丙二醛和总抗氧化能力。发红,杂种,充氧过多,常氧,对有或没有体外循环(CPB)的心脏手术进行了比较.
■发现年龄与术前总抗氧化剂状态值呈正相关。发红和亚黄病患者术前没有不同的抗氧化储备能力。虽然术前硫代巴比妥酸反应性物质(TBARS)水平在紫癜患者中明显较低,术后水平较高。术后TBARS水平升高,GSH水平降低。氧合水平没有引起氧化应激标志物的显着差异。CPB的持续时间对氧化应激没有负面影响。
■发红和年轻患者更容易受到氧化应激的影响。TBARS水平的升高和GSH水平的降低可能是氧化损伤的指标,取决于许多因素,如手术,CPB,缺血/再灌注,炎症,铁过载和氧合。氧合水平不会引起氧化应激的明显差异。CPB引起氧化应激,但是如果进行得当,CPB的持续时间不会对氧化应激造成显著的负面影响。
UNASSIGNED: Oxidative stress can cause many diseases and increases the risk of post-operative complications in children with congenital heart disease. For these reasons, this study was aimed to investigate the differences between
cyanotic and acyanotic paediatric patients who underwent heart surgery with markers of oxidative stress.
UNASSIGNED: Eighty five patients were included in the study. The samples taken before the surgery and within the first 24 h after the surgery were evaluated for haemoglobin (Hb), leukocytes, uric acid, glutathione (GSH), malondialdehyde and total antioxidant capacity.
Cyanotic, acyanotic, hyperoxygenated, normo-oxygenated, cardiac surgery with or without cardiopulmonary bypass (CPB) comparisons were made.
UNASSIGNED: Positive correlation was found between age and pre-operative total antioxidant status values.
Cyanotic and acyanotic patients did not have different antioxidant reserve capacities preoperatively. Although pre-operative thiobarbituric acid reactive substances (TBARS) levels were significantly lower in
cyanotic patients, post-operative levels were higher. TBARS levels increased and GSH levels reduced postoperatively. The level of oxygenation did not cause a significant difference on markers of oxidative stress. The duration of CPB did not have negative effects on oxidative stress.
UNASSIGNED: Cyanotic and younger patients were found to be more vulnerable to oxidative stress. The increased levels of TBARS and the decreased levels of GSH could be the indicators of oxidative damage depending on many factors such as surgery, CPB, ischaemia/reperfusion, inflammation, iron overload and oxygenation. The level of oxygenation does not cause a noticeable difference in oxidative stress. CPB causes oxidative stress, but if it is conducted appropriately, the duration of CPB does not cause a significant negative impact on oxidative stress.