肺炎支原体(Mp)可引起多种肺外表现,最常见的是皮肤病学的。目前尚不清楚Mp基因型是否决定Mp诱导的皮肤疾病。我们研究的目的是评估Mp基因型与该临床结果之间的关联。我们对2014年1月1日至2014年12月31日有急性Mp感染征象的儿童进行了回顾性研究。我们比较了表现为皮肤疾病的儿童的特征,上(URTI)和下呼吸道感染(LRTI)。此外,我们分别分析了Mp诱发皮肤病患者的数据.我们评估了435例患者的数据(平均年龄7.3岁,SD3.4年;52.0%的男孩)MpPCR阳性咽拭子,P1基因型和/或多位点可变数串联重复分析(MLVA)基因型定义,没有病毒共检测,表现为皮肤病(38/435),URTI(46/435)或LRTI(351/435)。大多数患者患有荨麻疹(55%,21/38)或斑丘疹(37%,14/38)。我们发现Mp基因型与皮肤病的临床结果之间没有关联,也没有任何具体的皮肤病学表现。在皮肤疾病组中,18%(7/38)因皮疹需要入院。我们发现MLVA-3,6,6,2株感染在住院患者中比门诊患者更常见(40%vs.4%,p=0.017),并且在逻辑回归模型中显着影响了住院的可能性。我们的队列研究结果表明,Mp基因型不能确定Mp引起的皮肤病或特定的皮肤病表现。然而,某些MLVA菌株感染可诱发更严重的皮肤病,需要住院治疗.
Mycoplasma pneumoniae (Mp) can cause several extrapulmonary manifestations, most frequently dermatological ones. It is largely unknown whether Mp genotype determines Mp-induced cutaneous disease. The aim of our study was to assess the association between Mp genotype and this clinical outcome. We performed a retrospective study of children referred with signs of acute Mp infection from 1 January 2014 to 31 December 2014. We compared the characteristics of children presenting as cutaneous disease, upper (URTI) and lower respiratory tract infection (LRTI). In addition, we separately analyzed the data of patients presenting with Mp-induced cutaneous disease. We evaluated data from 435 patients (mean age 7.3 years, SD 3.4 years; 52.0% boys) who had Mp PCR-positive pharyngeal swab, P1 genotype and/or multilocus variable-number tandem-repeat analysis (MLVA) genotype defined and no viral co-detection, presenting as cutaneous disease (38/435), URTI (46/435) or LRTI (351/435). The majority of patients had urticarial (55%, 21/38) or maculopapular eruptions (37%, 14/38). We found no association between Mp genotype and clinical outcome of cutaneous disease, nor any specific dermatological presentation. In the group with cutaneous disease, 18% (7/38) required hospital admission because of rash. We found that infection with MLVA-3,6,6,2 strains was more common in admitted patients than in outpatients (40% vs. 4%, p = 0.017) and significantly affected the likelihood of hospital admission in a logistic regression model. The results of our cohort study suggest that Mp genotype does not determine Mp-induced cutaneous disease or a specific dermatological presentation. Nevertheless, infections with certain MLVA strains could induce more severe cutaneous disease requiring hospitalization.