背景:在本文中,我们介绍了在富含血小板的血浆(PRP)和冷沉淀的组合中浸泡的厚层自体皮肤移植物的首次应用,治疗了四例二度和三度烧伤。
方法:我们描述了四例35、10、24和5岁男性的二度和三度烧伤,分别。在这些情况下受影响的总身体表面积(TBSA)范围为10%至35%。烧伤区域包括整个上背部和下背部,下肢,和头,根据哈里森的分类,涉及颅骨的外表。为了加快伤口愈合,我们应用了浸泡在冷沉淀和PRP混合物中的分层厚度自体移植物。此外,我们用浸泡在相同混合物中的敷料覆盖移植物,导致成功的移植物接受和改善烧伤愈合。
结论:皮肤伤口愈合涉及血管生成增加,再上皮化,和炎症的调节。PRP已被证明可以增强上皮再形成,皮肤伤口愈合的关键过程。然而,缺乏关于冷沉淀在上皮再形成中的作用的研究。因此,我们建议使用冷沉淀和PRP联合浸泡的自体皮肤移植物来加速愈合。
结论:本病例系列表明,使用浸泡在冷沉淀和PRP混合物中的厚薄自体移植物可显著改善和加速烧伤愈合,同时有助于可接受的移植结果。
BACKGROUND: In this paper, we present the first application of split-thickness skin autografts soaked in a combination of platelet-rich plasma (PRP) and
cryoprecipitate for four cases of second and third-degree burns.
METHODS: We describe four cases of second and third-degree burns in males aged 35, 10, 24, and 5 years, respectively. The total body surface area (TBSA) affected in these cases ranged from 10 % to 35 %. The burn areas included the entire upper and lower back, the lower limbs, and the head, with involvement of the outer table of the calvarium according to Harrison\'s classification. To expedite wound healing, we applied split-thickness autografts soaked in a mixture of
cryoprecipitate and PRP. Additionally, we covered the grafts with dressings soaked in the same mixture, resulting in successful graft acceptance and improved burn healing.
CONCLUSIONS: Skin wound healing involves increased angiogenesis, re-epithelialization, and modulation of inflammation. PRP has been shown to enhance re-epithelialization, a crucial process in skin wound healing. However, there is a lack of studies on the role of
cryoprecipitate in re-epithelialization. Therefore, we propose the use of autologous skin grafts soaked in a combination of
cryoprecipitate and PRP to expedite healing.
CONCLUSIONS: This case series demonstrates that the use of split-thickness autografts soaked in a mixture of
cryoprecipitate and PRP significantly improves and accelerates burn healing while contributing to acceptable graft outcomes.