目的：使用光学相干断层扫描血管造影（OCT-A）比较拥挤的椎间盘和对照组之间的浅表和深层血管特性。
方法：30例椎间盘拥挤患者，47名对照受试者被纳入研究。包括每个个体的一只眼睛,并且在4.5X4.5mm2的矩形区域中获得视盘的OCT-A扫描。径向乳头周围毛细血管（RPC）密度，乳头周围视网膜神经纤维层（pRNFL）厚度，杯子体积,边缘区域,光盘面积,杯盘面积比（c/d），使用设备软件自动获得垂直c/d比。使用MATLAB软件计算自动毛细血管旁脉络膜微脉管系统(PPCMv)密度。当视盘的垂直c/d比缺失或小杯时，它被认为是一个拥挤的光盘。
结果：在拥挤的椎间盘和对照眼之间，OCT-A图像的平均信号强度指数相似（P=0.740）。两组间pRNFL差异无统计学意义(P=0.102)。整个图像（P=0.826）和乳头周围区域（P=0.923）的RPC密度无差异。但是在拥挤的视盘中，盘内RPC密度较高（P=0.003）。在拥挤的椎间盘中，内半上区域的PPCMv密度也较低（P=0.026）。pRNFL厚度与乳头周围RPC密度呈正相关(r=0.498,P<0.001)。椎间盘内RPC密度与c/d面积比呈负相关(r=-0.341,P=0.002)。
结论：在拥挤的视盘眼中，椎间盘内RPC密度较高，而内半上PPCMv密度较低。
OBJECTIVE: To compare superficial and deep vascular properties of optic discs between crowded discs and controls using optical coherence tomography angiography (OCT-A).
METHODS: Thirty patients with crowded discs, and 47 control subjects were enrolled in the study. One eye of each individual was included and OCT-A scans of optic discs were obtained in a 4.5×4.5 mm2 rectangular area. Radial peripapillary capillary (RPC) density, peripapillary retinal nerve fiber layer (pRNFL) thickness, cup volume, rim area, disc area, cup-to-disc (c/d) area ratio, and vertical c/d ratio were obtained automatically using device software. Automated parapapillary choroidal microvasculature (PPCMv) density was calculated using MATLAB software. When the vertical c/d ratio of the optic disc was absent or small cup, it was considered as a crowded disc.
RESULTS: The mean signal strength index of OCT-A images was similar between the crowded discs and control eyes (P=0.740). There was no difference in pRNFL between the two groups (P=0.102). There were no differences in RPC density in whole image (P=0.826) and peripapillary region (P=0.923), but inside disc RPC density was higher in crowded optic discs (P=0.003). The PPCMv density in the inner-hemisuperior region was also lower in crowded discs (P=0.026). The pRNFL thickness was positively correlated with peripapillary RPC density (r=0.498, P<0.001). The inside disc RPC density was negatively correlated with c/d area ratio (r=-0.341, P=0.002).
CONCLUSIONS: The higher inside disc RPC density and lower inner-hemisuperior PPCMv density are found in eyes with crowded optic discs.
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