■外周动脉疾病(PAD)在全球范围内呈上升趋势,排名为动脉粥样硬化相关发病率的第三大原因;对甲基苯丙胺和可卡因使用者的住院趋势知之甚少。
■我们的目标是评估美国各地使用或不使用兴奋剂滥用(甲基苯丙胺和可卡因)的PAD住院率的总体趋势。此外,我们评估了按年龄分层的PAD相关住院趋势,种族,性别,和地理位置。
■我们使用了2008年至2020年的国家住院患者样本(NIS)数据库。CochranArmitage趋势检验用于比较组间的趋势。多变量逻辑回归用于检查甲基苯丙胺和可卡因使用者中PAD和CLI住院的校正几率。
■在2008年至2020年之间,与PAD相关的住院人数在西班牙裔中呈增加趋势,非洲裔美国人,和西方国家,而南部和中西部各州呈下降趋势(p趋势<0.05)。在甲基苯丙胺使用者中,男性总体呈上升趋势,女人,西方,南方,和中西部各州(p趋势<0.05)。然而,在可卡因使用者中,与PAD相关的住院率显着增加,非洲裔美国人,年龄组>64岁,南部和西部各州(p趋势<0.05)。总的来说,与CLI相关的住院率在男性和女性中显示出令人鼓舞的下降趋势,年龄组>64岁,女性与CLI相关的截肢减少,白人患者群体,年龄组>40岁,所有地区(p趋势<0.05)。然而,在甲基苯丙胺使用者中,在男性中,与CLI相关的住院有显著增加的趋势,女人,白人和西班牙裔人口,26-45岁年龄组,西方,南方,和中西部地区。
在男性和女性的甲基苯丙胺和可卡因使用者中,与PAD相关的住院治疗呈增加趋势。尽管两种性别的CLI相关住院总体呈下降趋势,在甲基苯丙胺使用者中,CLI呈上升趋势.怀特的上升趋势更为突出,西班牙裔和非洲裔美国人,南部和西部各州,突出研究期间的种族和地理差异。
UNASSIGNED: Peripheral artery disease (PAD) is on the rise worldwide, ranking as the third leading cause of atherosclerosis-related morbidity; much less is known about its trends in hospitalizations among methamphetamine and cocaine users.
UNASSIGNED: We aim to evaluate the overall trend in the prevalence of hospital admission for PAD with or without the use of stimulant abuse (methamphetamine and cocaine) across the United States. Additionally, we evaluated the PAD-related hospitalizations trend stratified by age, race, sex, and geographic location.
UNASSIGNED: We used the National Inpatient Sample (NIS) database from 2008 to 2020. The Cochran Armitage trend test was used to compare the trend between groups. Multivariate logistic regression was used to examine adjusted odds for PAD and CLI hospitalizations among methamphetamine and cocaine users.
UNASSIGNED: Between 2008 and 2020, PAD-related hospitalizations showed an increasing trend in Hispanics, African Americans, and western states, while a decreasing trend in southern and Midwestern states (p-trend <0.05). Among methamphetamine users, an overall increasing trend was observed in men, women, western, southern, and midwestern states (p-trend <0.05). However, among cocaine users, PAD-related hospitalization increased significantly for White, African American, age group >64 years, southern and western states (p-trend <0.05). Overall, CLI-related hospitalizations showed an encouraging decreasing trend in men and women, age group >64 years, and CLI-related amputations declined for women, White patient population, age group >40, and all regions (p-trend <0.05). However, among methamphetamine users, a significantly increasing trend in CLI-related hospitalization was seen in men, women, White & Hispanic population, age group 26-45, western, southern, and midwestern regions.
UNASSIGNED: There was an increasing trend in PAD-related hospitalizations among methamphetamine and cocaine users for both males and females. Although an overall decreasing trend in CLI-related hospitalization was observed for both genders, an up-trend in CLI was seen among methamphetamine users. The upward trends were more prominent for White, Hispanic & African Americans, and southern and western states, highlighting racial and geographic variations over the study period.