■评估超声(US)引导的粗针活检(CNB)在软组织肿瘤(STT)诊断中的诊断率,并分析失败因素。
■回顾性收集了139例接受US指导的CNB和手术切除的STT患者。与手术切除的组织病理学结果相比,活检失败被定义为以下条件:不明确的诊断,包括样本不足和具有正确生物潜力分类的未知亚型;错误的诊断,包括错误的生物潜能分类和具有正确生物潜能分类的错误亚型。从组织病理学角度进行单变量和多变量分析,我们进行了人口统计学特征和US特征以及活检程序,以确定诊断失败的危险因素.
■在我们的研究中,美国指导的CNB对STT的诊断率为78.4%,但是当只考虑STT的正确生物潜力分类时,诊断率为80.6%.多因素分析显示脂肪细胞肿瘤(比值比(OR)=10.195,95%置信区间(CI):1.062-97.861,p=0.044),血管肿瘤(OR=41.710,95%CI:3.126-556.581,p=0.005)和不确定的US诊断(OR=8.641,95%CI:1.852-40.303,p=0.006)与诊断失败相关.III级血管密度(OR=0.019,95%CI:0.001-0.273,p=0.007)使诊断准确性更高。
■美国指导的CNB可以是诊断STT的有效方式。当彩色多普勒超声中肿瘤血管密度为III级时,诊断率可以增加,但在脂肪细胞肿瘤中可以减少,美国诊断不确定的血管肿瘤和肿块。
UNASSIGNED: To evaluate the diagnostic yield of ultrasonography (US)-guided core needle biopsy (CNB) in the diagnosis of soft tissue tumors (STTs) and to analyze the failure factors.
UNASSIGNED: 139 patients with STTs that underwent both US-guided CNB and surgical resection were collected retrospectively. Compared with the histopathological results of surgical resection, the biopsy failure was defined as the following conditions: indefinitive diagnosis, including insufficient samples and unknown subtypes with correct biological potential classification; wrong diagnosis, including wrong biological potential classification and wrong subtypes with correct biological potential classification. Univariate and multivariate analyses from the perspectives of histopathological, demographic and US features together with biopsy procedures were performed to determine risk factors for diagnostic failure.
UNASSIGNED: The diagnostic yield of US-guided CNB for STTs in our study was 78.4%, but when only considering the correct biological potential classification of STTs, the diagnostic yield was 80.6%. The multivariate analysis showed that adipocytic tumors (odds ratio (OR) = 10.195, 95% confidence interval (CI): 1.062 - 97.861, p = 0.044), vascular tumors (OR = 41.710, 95% CI: 3.126 - 556.581, p = 0.005) and indeterminate US diagnosis (OR = 8.641, 95% CI: 1.852 - 40.303, p = 0.006) were correlated with the diagnostic failure. The grade III vascular density (OR = 0.019, 95% CI: 0.001 - 0.273, p = 0.007) enabled a higher diagnostic accuracy.
UNASSIGNED: US-guided CNB can be an effective modality for the diagnosis of STTs. The diagnostic yield can be increased when the tumor vascular density was grade III in Color Doppler US, but can be decreased in adipocytic tumors, vascular tumors and masses with indeterminate US diagnosis.