■先前关于肺活量测定与高密度脂蛋白(HDL)胆固醇之间相关性的发现很有趣,但却相互矛盾。这项研究的目的是评估中国慢性阻塞性肺疾病(COPD)患者的HDL水平与肺活量和影像学参数之间的关系。
■本研究共纳入907名COPD患者。参与者从问卷调查中获得完整的数据,血脂谱检查,肺活量测定测试,和计算机断层扫描(CT)扫描包括在分析中.采用广义累加模型来识别HDL水平与肺活量测定和成像参数之间的非线性关系。在存在非线性相关性的情况下,采用分段线性回归模型确定阈值效应。
■在对各种因素进行调整后,我们发现HDL水平和肺活量测定/成像参数之间存在非线性相关性,拐点为4.2(66mg/dL)。当Ln(HDL)低于4.2时,每个单位的增加与支气管扩张剂后FEV1的减少显着相关(0.32L,95%CI:0.09-0.55),预测FEV1%(11.0%,95%CI:2.7-19.3),并降低FEV1/FVC(8.0%,95%CI:4.0-12.0),Ln(LAA-950)显著增加1.20(95%CI:0.60-1.79),Ln(LAA-856)显著增加0.77(95%CI:0.37-1.17)。然而,当Ln(HDL)大于或等于4.2时,未观察到显著关联.
■COPD患者HDL水平与肺功能和CT影像学之间存在非线性相关性。在达到66mg/dL之前,HDL升高与肺功能受损显著相关,更严重的气体滞留和肺气肿。
UNASSIGNED: The previous findings on the correlation between spirometry and high-density lipoprotein (HDL) cholesterol are intriguing yet conflicting. The aim of this research is to evaluate the relationship between HDL levels and spirometry as well as imaging parameters in patients with chronic obstructive pulmonary disease (COPD) in China.
UNASSIGNED: This study encompasses a total of 907 COPD patients. Participants with complete data from questionnaire interviews, lipid profile examinations, spirometry testing, and computed tomography (CT) scans were included in the analysis. A generalized additive model was employed to identify the non-linear relationship between HDL levels and both spirometry and imaging parameters. In the presence of non-linear correlations, segmented linear regression model was applied to ascertain threshold effects.
UNASSIGNED: After adjusting for various factors, we found a non-linear correlation between HDL levels and spirometry/imaging parameters, with an inflection point at 4.2 (66 mg/dL). When Ln (HDL) was below 4.2, each unit increase correlated significantly with reduced post-bronchodilator FEV1 (0.32L, 95% CI: 0.09-0.55), decreased predicted FEV1% (11.0%, 95% CI: 2.7-19.3), and lowered FEV1/FVC (8.0%, 95% CI: 4.0-12.0), along with notable increases in Ln (LAA-950) by 1.20 (95% CI: 0.60-1.79) and Ln (LAA-856) by 0.77 (95% CI: 0.37-1.17). However, no significant associations were observed when Ln (HDL) was greater than or equal to 4.2.
UNASSIGNED: A non-linear correlation existed between HDL levels with lung function and CT imaging in COPD patients. Prior to reaching 66 mg/dL, an elevation in HDL was significantly associated with impaired lung function, more severe gas trapping and emphysema.