早期识别新生儿的听觉障碍对于防止发育迟缓至关重要。耳声排放(OAE)筛查在新生儿听力评估中起着至关重要的作用。然而,这些测试的理想出生后时间仍不清楚.这项研究评估了出生后前五天内OAE筛查的功效,以确定最有效的时机。一项观察性研究涉及三级护理中心的1,013名足月新生儿。根据WHO和JCIH指南,从第1天到第5天,这些新生儿每天接受瞬时诱发耳声发射(TEOAE)筛查。这项研究评估了通过率,假阳性,和假阴性,在1个月和3个月时对最初结果不明确的新生儿进行随访筛查。研究发现,筛选效率显著提高,到第5天,第1天通过率为8%(81名新生儿)和98%(992名新生儿),这标志着诊断准确性的显着提高(p<0.001)。假阳性率从第1天的92%下降到第5天的2%,假阴性下降到1%以下。敏感性和特异性分别在98%和99.5%达到峰值,分别,在第五天。我们的研究结果主张调整新生儿听力筛查方案,包括出生后第五天的OAE测试,通过提高诊断准确性和减少家庭和医疗保健提供者的后勤和情感负担来优化临床疗效。
■在线版本包含补充材料,可在10.1007/s12070-024-04700-0获得。
Identifying auditory impairments early in newborns is essential to prevent developmental delays. Otoacoustic Emissions (OAE) screenings play a critical role in newborn hearing assessments. However, the ideal timing post-birth for these tests remains unclear. This study evaluates the efficacy of OAE screenings within the first five days after birth to determine the most effective timing. An observational study involved 1,013 full-term neonates at a tertiary care centre. These neonates underwent Transient Evoked Otoacoustic Emissions (TEOAE) screenings daily from Day 1 to Day 5, following WHO and JCIH guidelines. The study assessed pass rates, false positives, and false negatives, with follow-up screenings at one and three months for neonates with initial ambiguous results. The study found that screening efficiency significantly increased, with Day 1 pass rates at 8% (81 neonates) and 98% (992 neonates) by Day 5, marking a significant improvement in diagnostic accuracy (p < 0.001). False positive rates dropped from 92% on Day 1 to 2% by Day 5, and false negatives decreased to below 1%. Sensitivity and specificity reached their peak at 98% and 99.5%, respectively, on Day 5. Our study findings advocate for adjusting neonatal hearing screening protocols to include OAE tests on the fifth day post-birth, optimizing clinical efficacy through enhanced diagnostic accuracy and reducing the logistical and emotional burdens on families and healthcare providers.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12070-024-04700-0.