心理健康问题对传染病风险的因果影响仍然模糊。通过观察性研究来调查它们是具有挑战性的,因为它提出了可能的混杂因素。因此,本研究的目的是利用孟德尔随机化(MR)技术评估心理健康问题与传染病风险之间的因果关系.使用睡眠障碍的全基因组关联数据(N=216,700)进行了多变量MR分析,抑郁症(N=500,199),焦虑(N=290,361),紧张的感觉(N=450,700),未指明的精神障碍(N=218,792),肺炎(N=486,484),皮肤和皮下组织感染(SSTI;N=218,792),肠道传染病(IIDs;N=218,792),尿路感染(N=463,010),欧洲血统个体的中枢神经系统(CNS)感染(N=218,792)。与每次暴露显著相关的独立遗传变异(P<10-8)被认为是仪器。初步分析采用方差加权逆方法,接下来是一系列的敏感性分析。遗传预测的睡眠障碍与SSTI风险增加相关(比值比[OR],1.29[95%置信区间(CI),1.05-1.59];P=.017)。遗传预测的抑郁症与中枢神经系统感染的风险增加有关(OR,1.59[95%CI,1.00-2.53];P=.049)和SSTI(1.24[95%CI,1.03-1.49];P=.024)。遗传预测的焦虑与IID(OR,1.19[95%CI,1.03-1.37];P=0.017)和SSTI(OR,1.21[95%CI,1.02-1.43];P=0.029)。没有明显的因果关系的遗传预测的神经感觉和非特定的精神障碍的IIDs,CNS感染,SSTI,肺炎,或者尿路感染.敏感性分析表明,上述因果关联估计是稳健的。在这项MR研究中,我们证明了睡眠障碍之间的因果关系,抑郁症,焦虑,和传染病的风险。然而,没有证据支持紧张情绪之间的因果关系,未指明的精神障碍,和传染病的风险。
The causal effects of mental health problems on the risk of infectious diseases remain vague. Investigating them via observational study is challenging as it presents possible confounding factors. Therefore, the objective of this study was to utilize Mendelian randomization (MR) techniques to evaluate the causal relationship between mental health problems and the risk of infectious diseases. Multivariable MR analyses were performed using genome-wide association data for sleep disorders (N = 216,700), depression (N = 500,199), anxiety (N = 290,361), nervous feelings (N = 450,700), unspecified mental disorder (N = 218,792), pneumonia (N = 486,484), skin and subcutaneous tissue infection (SSTI; N = 218,792), intestinal infectious diseases (IIDs; N = 218,792), urinary tract infection (N = 463,010), and central nervous system (CNS) infections (N = 218,792) among individuals of European ancestry. Independent genetic variants significantly (P < 10-8) associated with each exposure were considered instruments. The primary analysis used an inverse variance-weighted method, followed by a series of sensitivity analyses. Genetically predicted sleep disorders were associated with an increased risk of SSTI (odds ratio [OR], 1.29 [95% confidence interval (CI), 1.05-1.59]; P = .017). Genetically predicted depression was linked with an increased risk of CNS infections (OR, 1.59 [95% CI, 1.00-2.53]; P = .049) and SSTI (1.24 [95% CI, 1.03-1.49]; P = .024). Genetically predicted anxiety was associated with IIDs (OR, 1.19 [95% CI, 1.03-1.37]; P = .017) and SSTI (OR, 1.21 [95% CI, 1.02-1.43]; P = .029). There was no significant causal evidence for genetic prediction of nervous feelings and unspecified mental disorders in IIDs, CNS infections, SSTI, pneumonia, or urinary tract infection. Sensitivity analyses showed that the above causal association estimates were robust. In this MR study, we demonstrated a causal relationship between sleep disorders, depression, anxiety, and the risk of infectious diseases. However, no evidence was found to support causality between nervous feelings, unspecified mental disorders, and the risk of infectious diseases.