■强迫症(OCD)是一种使人衰弱的精神健康状况,通常在大多数情况下表现为高度的共病症状。虽然面对面的认知行为疗法(CBT)被认为是治疗儿童强迫症的黄金标准,它的可访问性,可用性,交付的一致性仍然有限。为了应对其中一些挑战,创建并引入了增强型CBT(eCBT)包。这项研究探讨了eCBT对强迫症相关共病症状的广泛影响,功能损害,强迫症青年的生活质量和家庭住宿。
■这项开放试验涉及25名患有强迫症(7-17岁)的儿科患者,在2018年1月至2020年2月期间评估。所有患者均接受eCBT治疗14周。在基线时评估次要结果,治疗后,and3-,6-,和12个月的随访共同发生的症状使用优势和困难问卷(SDQ)进行评估,儿童焦虑相关情绪障碍(恐惧)的屏幕,和情绪和情感问卷(MFQ)。使用KINDL-R测量生活质量,通过儿童强迫性影响量表修订(COIS-R),和家庭住宿按家庭住宿量表(FAS)。线性混合效应模型用于分析治疗效果。
■结果表明,治疗后强迫症相关的共病症状显着减少,SDQ平均降低3.73(SE=1.10,孩子)和4.14(SE=1.19,父母),害怕平均减少10.45(SE=2.52,孩子)和8.40(SE=2.82,父母),MFQ平均降低3.23(SE=1.11,儿童)和2.69(SE=1.18,父母)。家庭住宿下降,临床医生得分FAS平均减少13.25(SE=2.31)。治疗后生活质量明显改善,KINDL平均增加8.15(SE=2.87,儿童),和10.54(SE=3.07,父母)。这些积极的改善在3个月的随访中进一步放大,并且在12个月的随访中保持一致。
■从基线到治疗后,观察到所有次要结局和强迫症相关功能损害均显着降低,通过12个月的随访维持。这些结果表明,在接受eCBT后,儿童和青少年的OCD相关症状对他们日常生活的负面影响大幅下降,包括家,学校,和社会互动。
UNASSIGNED: Obsessive-compulsive disorder (OCD) is a debilitating mental health condition usually presenting with a high degree of comorbid symptoms in the majority of cases. Although face-to-face cognitive-behavioral therapy (CBT) is considered the therapeutic golden standard for pediatric OCD, its accessibility, availability, and consistency in delivery are still limited. To address some of these challenges, an enhanced CBT (eCBT) package was created and introduced. This study explored eCBT\'s broad-based impact on OCD-related comorbid symptoms, functional impairment, quality of life and family accommodation among youth with OCD.
UNASSIGNED: This open trial involved 25 pediatric patients with OCD (7-17 years), assessed between January 2018 to February 2020. All patients received eCBT for 14 weeks. Secondary outcomes were assessed at baseline, post-treatment, and 3-, 6-, and 12-month follow-up co-occurring symptoms were evaluated using the Strengths and Difficulties Questionnaire (SDQ), Screen for Child Anxiety-Related Emotional Disorders (SCARED), and Mood and Feelings Questionnaire (MFQ). Quality of life was measured using the KINDL-R, functional impairment through the Child Obsessive-Compulsive Impact Scale Revised (COIS-R), and family accommodation by the Family Accommodation Scale (FAS). Linear mixed-effects models were applied to analyze treatment effects.
UNASSIGNED: Results indicated a significant decrease in OCD-related comorbid symptoms post-treatment, with SDQ mean reduce of 3.73 (SE = 1.10, child) and 4.14 (SE = 1.19, parent), SCARED mean reduce of 10.45 (SE = 2.52, child) and 8.40 (SE = 2.82, parent), MFQ mean reduce of 3.23 (SE = 1.11, child) and 2.69 (SE = 1.18, parent). Family accommodation declined with clinician scored FAS mean reduction of 13.25 (SE = 2.31). Quality-of-Life improved significantly post-treatment, with KINDL mean increase of 8.15 (SE = 2.87, children), and 10.54 (SE = 3.07, parents). These positive improvements were further amplified at the 3-month follow-up and remained consistent at the 12-month follow-up.
UNASSIGNED: A significant reduction was observed in all secondary outcomes employed and OCD-related functional impairments from baseline to post-treatment, which was maintained through 12-month follow-up. These results imply that after receiving eCBT, children and adolescents experienced substantial decrease in the negative impacts of OCD-related symptoms on their daily life, including home, school, and social interactions.