cognitive behavior therapy

认知行为疗法
  • 文章类型: Journal Article
    背景:已经存在基于群体的创伤聚焦认知行为疗法(TF-CBT)有效性的证据,但对基于群体的TF-CBT如何治疗PTSD儿童知之甚少。本研究的目的是探索降低基于群体的TF-CBT中PTSD严重程度的介质。
    方法:我们分析了一项在中国进行的随机对照试验的数据。在这次审判中,234名患有PTSD的儿童被随机分配到TF-CBT组或照常治疗(TAU)组。主要结果(创伤后应激障碍症状的严重程度降低)和可能的介质(创伤记忆质量,情绪调节策略,和弹性)在基线和治疗后进行评估。进行中介分析以研究可能的中介对治疗结果的间接影响。
    结果:中介模型显示创伤记忆质量的变化,适应不良的情绪调节策略,和韧性介导的群体之间的关系(TF-CBTvs.TAU)和治疗后的PTSD。适应性情绪调节策略不是基于群体的TF-CBT减少PTSD的关键机制。
    结论:基于群体的TF-CBT可能通过减少危险因素影响PTSD,比如创伤记忆质量和适应不良情绪策略。基于群体的TF-CBT也可能通过增加保护因素影响PTSD,比如韧性。因此,在整个治疗过程中监测这些介质可能是优化治疗结局的重要因素.
    BACKGROUND: Evidence for the effectiveness of group-based trauma-focused cognitive behavior therapy (TF-CBT) has existed, but little is known about how group-based TF-CBT works in the treatment of children with PTSD. The purpose of the present study is to explore the mediators for the reduction of PTSD severity in group-based TF-CBT.
    METHODS: We analyzed data from a randomized controlled trial conducted in China. In this trial, 234 children with PTSD were randomly assigned to the TF-CBT group or the treatment as usual (TAU) group. The primary outcome (reduction in severity of PTSD symptoms) and possible mediators (trauma memory quality, emotion regulation strategies, and resilience) were assessed at baseline and posttreatment. The mediation analysis was performed to investigate the indirect effects of possible mediators on treatment outcomes.
    RESULTS: The mediation model revealed that changes in trauma memory quality, maladaptive emotion regulation strategies, and resilience mediated the relationship between the group (TF-CBT vs. TAU) and PTSD at post-treatment. Adaptive emotion regulation strategies were not a key mechanism underlying PTSD reduction in group-based TF-CBT.
    CONCLUSIONS: Group-based TF-CBT might affect PTSD by reducing risk factors, like trauma memory quality and maladaptive emotion strategies. Group-based TF-CBT also might affect PTSD by increasing protective factors, like resilience. Thus, monitoring these mediators throughout treatment might be an important factor in optimizing treatment outcomes.
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  • 文章类型: Journal Article
    人格障碍(PD)患者的治疗分配涉及一个复杂的过程,包括诊断评估和决定最合适的心理治疗。本文介绍了用于系统分析生活故事的清单的开发,以支持患者进行辩证行为疗法(DBT)或以模式为中心的疗法(SFT)的反思和透明分配。在第一项研究中,电子邮件调查,焦点小组,在8位临床专家中进行了成员检查,以确定PD患者生活故事中的相关维度.在第二项研究中,在三轮测试中,九名临床专家和九名心理学学生制定了基于这些维度的检查表。将清单结果与20例患者的实际分配治疗进行比较。对生活故事的系统评估,通过关注患者生活故事中的特定和共识维度,有望支持将PD患者分配到合适的治疗方法。
    Treatment assignment for patients with personality disorders (PDs) involves a complex process consisting of diagnostic assessment and deciding on the most appropriate psychotherapeutic treatment. This article describes the development of a checklist for systematic analysis of life stories to support reflective and transparent assignment of patients to either dialectical behavioral therapy (DBT) or schema-focused therapy (SFT). In a first study, an email survey, focus group, and member check were conducted among eight clinical experts to identify relevant dimensions in life stories in patients with PDs. In a second study, a checklist based on these dimensions was developed in three rounds of testing with nine clinical experts and nine psychology students. Checklist results were compared to actual assigned treatment for 20 patients. Systematic evaluation of life stories, is promising in supporting the allocation of patients with PDs to a suitable treatment approach by focusing on specific and consensual dimensions in patients\' life stories.
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  • 文章类型: English Abstract
    The aim of this study was to differentiate between types of bipolar disorders and the associated features using explorative analysis. The focus was particularly on the role of bipolar 1 and bipolar 2 disorders as well as the influence of prophylactic interventions for relapse in a randomized, controlled treatment study. A total of 274 of the 305 originally included persons could be investigated in the study. Patients participated in either cognitive behavioral group therapy (SEKT) or supportive, patient-centered group therapy (FEST). Treatment took place over 4 days separated by a 1-month interval (equivalent to 16 double hours). Depressive and manic symptoms were assessed using the longitudinal interval follow-up evaluation (LIFE). The symptoms were retrospectively assessed for the previous 6 months, with respect to each week before and after the intervention phase and for 6‑month and 12-month follow-ups. The results show that the effects of both group therapies were comparable; however, there were statistically significant differences in a multivariate proportional hazards model for the factors bipolar 1 and 2 as well as the interaction of therapy with bipolar 1 and 2. In particular, bipolar 2 patients benefited significantly less from the SEKT intervention than from the FEST intervention. There were three clusters identified that separated bipolar 1 (SEKT, no comorbidity, predominantly no recurrences, younger patients), from bipolar 2 (FEST, no comorbidity, at least 1 often 2 recurrences, older patients) and from a heterogeneous group (SEKT and FEST, comorbidity). The distinction between bipolar 1 and bipolar 2 disorder is important and has so far not received sufficient attention. Bipolar 2 disorders generally have a worse course and respond particularly poorly to cognitive behavioral therapy (SEKT). An open, unstructured, supportive, patient-centered psychotherapy (FEST) is generally effective.
    UNASSIGNED: Anliegen dieser Arbeit ist es, mittels explorativer Auswertungen verschiedene Verlaufstypen bipolarer Störungen und den damit verbundenen Merkmalen zu differenzieren und dabei insbesondere die Rolle von Bipolar-1- und Bipolar-2-Störung sowie den Einfluss der rezidivprophylaktischen Interventionen im Rahmen einer randomisierten, kontrollierten Therapiestudie zu klären. Es konnten 274 der ursprünglich 305 eingeschlossenen Personen untersucht werden. Patienten nahmen entweder an einer kognitiv-verhaltenstherapeutischen (SEKT) oder unterstützenden, patientenzentrierten (FEST) Gruppentherapie teil, welche sich über 4 Therapietage (entspricht 16 Doppelstunden) in monatlichem Abstand erstreckte. Depressive und manische Symptomatik wurde anhand des LIFE jeweils für die zurückliegenden 6 Monate bezogen auf jede Woche vor und nach der Interventionsphase sowie 6 und 12 Monate katamnestisch beurteilt. Die Effekte beider Gruppentherapien erwiesen sich als vergleichbar. Statistisch signifikant wurden in einem multivariaten Proportional-Hazards-Modell jedoch der Faktor Bipolar 1 und 2 sowie die Interaktion von Therapie mit Bipolar 1 und 2. Insbesondere profitierten Bipolar-2-Patienten von der SEKT-Intervention deutlich schlechter als von FEST. Es ergaben sich 3 Cluster, die Bipolar 1 (SEKT, keine Komorbidität, mehrheitlich keine Rezidive, jüngere Patienten) von Bipolar 2 (FEST, keine Komorbidität, mindestens 1, oft 2 Rezidive, ältere Patienten) und von einer heterogenen Gruppe (beide Interventionen, Komorbidität) trennten. Die Unterscheidung von Bipolar-1- und Bipolar-2-Störung ist wichtig und bislang unzureichend berücksichtigt. Bipolar-2-Störungen zeigen generell einen schlechten Verlauf und sprechen auf eine kognitive Verhaltenstherapie (SEKT) besonders schlecht an. Eine offene, unstrukturierte, unterstützende, patientenzentrierte Psychotherapie (FEST) ist generell wirksam.
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  • 文章类型: Journal Article
    目标:虽然鼓励治疗师在治疗过程中平衡涉及患者问题的情感工作与需求满意度,这种平衡的影响很少被实证研究。因此,我们研究了认知行为疗法(CBT)中与问题相关的情感体验和需要满足体验之间的一致性效应.方法:165名陷入困境的家庭照顾者对与问题相关的情感经历进行评级,需要满足的经历包括自尊,积极的人际关系,和控制经验,以及12次CBT会议后的应对经验。我们研究了与问题相关的情感和需求满足经验对多级响应面分析中后续应对的人内一致性影响。Further,我们将与问题相关的人与人之间的情感和需要满足的经历以及治疗前的抑郁和焦虑纳入了人内效应的调节因素.结果:自尊心略大于与问题相关的情感经历,以及与问题相关的情感与人际关系和控制经历之间的精确对应,最能预测应对。人与人之间的主持人支持与问题相关的情感和自尊体验的跨级别平衡启发式方法。最后,在与问题相关的情感体验上,更加强调自尊和人际关系,这对高焦虑和低抑郁的患者更有益。结论:研究结果强调了在CBT中平衡与问题相关的情感和需求满意体验的重要性,并提供了如何针对特定患者量身定制平衡的见解。
    Objective: Although therapists are encouraged to balance emotionally involving work on the patient\'s problems with need satisfaction in therapy sessions, effects of this balance have rarely been studied empirically. Hence, we examined congruence effects between problem-related affective and need-satisfying experiences in cognitive-behavioral therapy (CBT). Method: 165 distressed family caregivers rated problem-related affective experiences, need-satisfying experiences comprising self-esteem, positive interpersonal, and control experiences, as well as coping experiences after 12 CBT sessions. We examined within-person congruence effects of problem-related affective and need-satisfying experiences on subsequent coping in multilevel response surface analysis. Further, we included between-person problem-related affective and need-satisfying experiences and pretreatment depression and anxiety as moderators of within-person effects. Results: A slight predominance of self-esteem over problem-related affective experiences as well as exact correspondence between problem-related affective and both interpersonal and control experiences was most predictive of coping. Between-person moderators supported a cross-level balance heuristic of problem-related affective and self-esteem experiences. Finally, a stronger emphasis on self-esteem and interpersonal over problem-related affective experiences proved more beneficial for patients with high anxiety and low depression. Conclusions: The findings highlight the importance of balancing problem-related affective and need-satisfying experiences in CBT and provide insights into how balancing may be tailored to specific patients.
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  • 文章类型: Journal Article
    卒中后抑郁(PSD)是一种普遍的精神疾病,影响约三分之一的卒中幸存者,显着阻碍恢复和生活质量。PSD还给护理人员和医疗保健系统带来了沉重负担。芳香疗法在缓解抑郁症方面显示出了希望,焦虑,和睡眠障碍。这项初步的随机对照试验旨在评估混合草药芳香疗法治疗PSD的可行性和初步疗效。可行性结果包括招聘,干预依从性,评估完成和安全评估。次要结果包括对抑郁症的评估,焦虑,认知功能,睡眠质量,生活质量,使用EEG和fNIRS的脑功能。
    这项单盲先导随机对照试验将在上海市第二康复医院进行,纳入99名卒中后PSD患者。参与者将被随机分为三组:接受标准化康复治疗的非主动对照组,CBT小组接受常规康复,每两周一次的CBT会议,和一个芳香疗法组接受常规康复和每日芳香吸入疗程。干预将持续四周,在基线时评估疗效,干预后,干预后一个月。评分量表将用于测量抑郁症的变化,睡眠质量,认知功能,和生活质量。EEG和fNIRS将专门用于测量大脑皮层活动的变化及其与抑郁症的相关性。可行性将通过招聘进行评估,干预依从性,评估完成和安全评估。
    这项初步研究强调了混合草药芳香疗法吸入治疗PSD的潜力,通过促进自我管理来解决CBT的局限性。在通过招聘证明可行性的同时,坚持,评估完成和安全评估,该研究还承认限制,如不平等的干预时间,缺乏身体功能数据。而且,使用与文化相关的植物粉末可能会增强依从性,但会限制通用性。尽管有这些限制,这项研究为芳香疗法的机制提供了有价值的初步数据和见解,鼓励进一步研究和开发有效的PSD治疗方法。
    UNASSIGNED: Post-stroke depression (PSD) is a prevalent psychiatric disorder affecting about one-third of stroke survivors, significantly hindering recovery and quality of life. PSD also imposes a substantial burden on caregivers and healthcare systems. Aromatherapy has shown promise in alleviating depression, anxiety, and sleep disorders. This pilot randomized controlled trial aims to assess the feasibility and preliminary efficacy of mixed herb aromatherapy in treating PSD. Feasibility outcomes encompass recruitment, intervention adherence, assessment completion and safety assessment. Secondary outcomes include evaluations of depression, anxiety, cognitive function, sleep quality, quality of life, and brain function using EEG and fNIRS.
    UNASSIGNED: This single-blind pilot randomized controlled trial will be conducted at the Second Rehabilitation Hospital of Shanghai, enrolling ninety-nine post-stroke patients with PSD. Participants will be randomized into three groups: a Non-Active Control Group receiving standardized rehabilitation therapy, a CBT Group receiving conventional rehabilitation with bi-weekly CBT sessions, and an Aromatherapy Group receiving conventional rehabilitation with daily aromatic inhalation sessions. Interventions will last for four weeks, with efficacy assessed at baseline, post-intervention, and one month post-intervention. Rating scales will be used to measure changes in depression, sleep quality, cognitive function, and quality of life. EEG and fNIRS will specifically be used to measure changes in cerebral cortex activity and their correlations with depression. Feasibility will be evaluated through recruitment, intervention adherence, assessment completion and safety assessment.
    UNASSIGNED: This pilot study highlights the potential of mixed herb aromatherapy inhalation for treating PSD, addressing limitations of CBT by promoting self-management. While demonstrating feasibility through recruitment, adherence, assessment completion and safety assessment, the study also acknowledges limitations such as unequal intervention times, the lack of physical function data. And the use of culturally relevant plant powders may enhance compliance but limits generalizability. Despite these constraints, the study provides valuable preliminary data and insights into the mechanisms of aromatherapy, encouraging further research and development of effective PSD treatments.
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  • 文章类型: Journal Article
    在战后地区,特别是在低收入国家,医疗保健系统通常需要立即支持。例如,在2014年所谓的伊拉克和叙利亚伊斯兰国(ISIS)恐怖之后,许多国内流离失所者在伊拉克库尔德斯坦地区(KRI)避难。那些因战争而流离失所的人不得不面对这样一个现实,即心理治疗在库尔德卫生系统中并不存在。在冲突后地区开展工作的许多项目和非政府组织侧重于短期和快速反应和/或基本心理服务。杜胡克大学“心理治疗和精神创伤研究所”(IPP)的实施,遵循长期的方法。为期3年的课程教导学生成为专业的心理治疗师,关于基于证据和文化适应的心理治疗方法。为了实现可持续性,该项目正在努力将教学和组织责任移交给当地。本文重点介绍了这一转变过程中的机遇和挑战,以及文化理解和现实的重要性,实用的解决方案。对现有文化挑战的诚实反思,例如,僵化的等级结构或对同性恋的“老式”宗教观点,然后可以导致实际的解决方案。其中包括通过将地方当局纳入这一过程来赢得地方当局的支持,在受过教育的当地人的帮助下,文化上适应习俗,展示非专制领导形式,并明确提拔刚毕业的年轻讲师担任权威职务。
    In post war regions, especially in low-income countries, the health care systems often require immediate support. For example, after the terror of the so-called Islamic State of Iraq and Syria (ISIS) in 2014, many internally displaced persons took refuge in the Kurdistan Region of Iraq (KRI). Those displaced by war have had to face the reality that psychotherapy did not exist as a service in the Kurdish health system. Many projects and Non-Government-Organizations (NGOs) that work in post-conflict regions focus on short term and quick response and/or basic psychological services. The implementation of the \"Institute for Psychotherapy and Psychotraumatology\" (IPP) at the University of Dohuk, follows a long-term approach. The 3-year-program teaches students to become professional psychotherapists, with respect to evidence-based and culturally adapted methods of psychotherapy. To achieve sustainability, the project is working towards handing over the teaching and organizational responsibilities into local hands. This article highlights the chances and challenges during this transition, as well as the importance of cultural understanding and realistic, practical solutions. An honest reflection on existing cultural challenges, e.g. inflexible hierarchical structures or an \"old-fashioned\" religious view of homosexuality, can then lead to practical solutions. These include winning over local authorities by including them in the process, culturally adapting to customs with the help of educated locals, demonstrating non-authoritarian forms of leadership, and explicitly promoting newly graduated young lecturers into positions of authority.
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  • 文章类型: Clinical Trial
    背景:这项工作探讨了基于认知行为疗法(CBT)的综合护理干预(CNI)模式在正畸骨弓扩张(OOA)患者中的作用。
    目的:探讨基于CBT的CNI模型在正畸扩弓治疗中的应用效果。
    方法:采用方便的取样方法,选择81例OOA患者,纳入对照组(Ctrl组,40例)和观察组(Obs组,41例)。在治疗过程中,Ctrl组患者接受常规护理干预模式,Obs组的人在此基础上接受了CBT模式。干预前后,口腔粘膜炎的发病率,正确扩拱方法的掌握率,焦虑自评量表评分,软标度指数,比较不同组患者的菌斑指数。此外,对患者满意度和并发症进行对比分析。
    结果:Obs组口腔黏膜炎的发生率较低(14.6%比38.5%),正确扩弓方法的掌握率明显较高(90.2%vs55.0%),明显较高(均P<0.05)。同时,Obs组的软量表指数和菌斑指数较低(P<0.05)。Obs组的依从性(90.24%)和满意度(95.12%)明显高于对照组(P<0.05)。
    结论:基于CBT的CNI模式大大提高了OOA患者扩弓过程中正确扩弓方法的掌握率,增强了扩弓的治疗效果和患者的口腔健康。提高患者的依从性。
    BACKGROUND: This work explored the effects of cognitive behavior therapy (CBT)-based comprehensive nursing intervention (CNI) mode in arch expansion to treat patients with orthodontic osteodilated arch (OOA).
    OBJECTIVE: To explore the application effect of CBT-based CNI model in orthodontic expansion arch treatment.
    METHODS: Using convenient sampling method, 81 patients with OOA were selected and rolled into a control group (Ctrl group, 40 cases) and an observation group (Obs group, 41 cases). During the treatment, patients in the Ctrl group received routine nursing intervention mode, and the those in the Obs group received CBT mode on the basis of this. Before and after intervention, the incidence of oral mucositis, the mastery rate of correct arch expansion method, self-rating anxiety scale score, soft scale index, and plaque index were compared for patients in different groups. In addition, satisfaction and complications were comparatively analyzed.
    RESULTS: Incidence of oral mucositis in the Obs group was lower (14.6% vs 38.5%), and the mastery rate of correct arch expansion method was obviously higher (90.2% vs 55.0%) was obviously higher (all P < 0.05). Meanwhile, the soft scale index and plaque index in the Obs group were much lower (P < 0.05). The compliance (90.24%) and satisfaction (95.12%) in the Obs group were greatly higher (P < 0.05).
    CONCLUSIONS: The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients, improving the patient compliance.
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  • 文章类型: Journal Article
    患有社交焦虑障碍(SAD)的个体经历整体情绪调节困难,但对此类困难在SAD的认知行为治疗(CBT)中的长期作用知之甚少。46名SAD患者接受互联网提供的CBT,和匹配的健康对照(HC;n=39),自我报告情绪调节困难量表(DERS),利博维茨社交焦虑量表(LSAS-SR),并参与了预期的言语焦虑行为实验。在之前的七个时间点测量患者,在总共28个月的CBT期间和之后,和HCs在两个时间点。使用了总共263个观察值的分类生长曲线模型,以及类内相关系数和回归模型。患者的LSAS-SR和DERS评分是可靠的(ICC分别为.83和.75),和病人,相对于控件,在治疗前表现出较大的情绪调节困难(p<.001)。在CBT期间,个体内情绪调节的改善显着预测了LSAS-SR的降低(p=.041,伪R2=43%)。因此,情绪调节的变化对于个人层面的监控可能很重要,并且可以用于改善互联网提供的CBT未来发展的结果。
    Individuals with social anxiety disorder (SAD) experience overall emotion regulation difficulties, but less is known about the long-term role of such difficulties in cognitive behavior therapy (CBT) for SAD. Forty-six patients with SAD receiving internet-delivered CBT, and matched healthy controls (HCs; n = 39), self-reported the Difficulties in Emotion Regulation Scale (DERS), Liebowitz Social Anxiety Scale (LSAS-SR), and participated in anticipatory speech anxiety behavioral experiments. Patients were measured at seven time points before, during and after CBT over a total period of 28 months, and HCs at two timepoints. Disaggregated growth curve models with a total of 263 observations were used, as well as intra-class correlation coefficients and regression models. Patients\' LSAS-SR and DERS ratings were reliable (ICC = .83 and .75 respectively), and patients, relative to controls, showed larger difficulties in emotion regulation at pre-treatment (p < .001). During CBT, within-individual improvements in emotion regulation significantly predicted later LSAS-SR reductions (p = .041, pseudo-R2 = 43%). Changes in emotion regulation may thus be important to monitor on an individual level and may be used to improve outcomes in future developments of internet-delivered CBT.
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  • 文章类型: Journal Article
    患有焦虑症(AD)的人经常对威胁信息表现出高度警惕,尽管这种反应在心理治疗后可能不太明显。本研究旨在探讨惊恐障碍(PD)患者治疗后面部表情的无意识识别表现,揭示他们情绪处理偏见的变化。
    经过(基于暴露的)认知行为治疗和健康对照(n=43)的PD患者(n=34)执行了潜意识情感识别任务。情感面部表情(恐惧,快乐,或镜像)显示33ms,并由中性面向后掩盖。参与者完成了一项强制选择任务,以区分短暂呈现的面部刺激和仅显示中性面具的未发现状况。我们进行了二次分析,以根据四种刺激条件下的四种可能的反应类型对群体进行比较,并检查了恐惧反应的误报率与非恐惧(快乐,镜像,并发现)具有临床焦虑症状的刺激。
    患者组对快乐表情表现出独特的选择模式,与对照组相比,“快乐”的反应明显更正确。此外,心理治疗后焦虑症状严重程度降低与无威胁表现的虚假恐惧反应率降低相关.
    这些数据表明,PD患者在接受心理治疗后表现出“快乐人脸识别优势”。治疗后症状减少与恐惧偏见减少有关。因此,在心理治疗的背景下,不同的面部情绪检测任务可能是监测AD患者反应模式和偏见的合适工具.
    UNASSIGNED: Individuals with anxiety disorders (ADs) often display hypervigilance to threat information, although this response may be less pronounced following psychotherapy. This study aims to investigate the unconscious recognition performance of facial expressions in patients with panic disorder (PD) post-treatment, shedding light on alterations in their emotional processing biases.
    UNASSIGNED: Patients with PD (n=34) after (exposure-based) cognitive behavior therapy and healthy controls (n=43) performed a subliminal affective recognition task. Emotional facial expressions (fearful, happy, or mirrored) were displayed for 33 ms and backwardly masked by a neutral face. Participants completed a forced choice task to discriminate the briefly presented facial stimulus and an uncovered condition where only the neutral mask was shown. We conducted a secondary analysis to compare groups based on their four possible response types under the four stimulus conditions and examined the correlation of the false alarm rate for fear responses to non-fearful (happy, mirrored, and uncovered) stimuli with clinical anxiety symptoms.
    UNASSIGNED: The patient group showed a unique selection pattern in response to happy expressions, with significantly more correct \"happy\" responses compared to controls. Additionally, lower severity of anxiety symptoms after psychotherapy was associated with a decreased false fear response rate with non-threat presentations.
    UNASSIGNED: These data suggest that patients with PD exhibited a \"happy-face recognition advantage\" after psychotherapy. Less symptoms after treatment were related to a reduced fear bias. Thus, a differential facial emotion detection task could be a suitable tool to monitor response patterns and biases in individuals with ADs in the context of psychotherapy.
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  • 文章类型: Journal Article
    在我们如何看待抑郁症及其治疗方面,范式正在发生变化。这种转变中的一些可以归因于其流行病学和遗传学方面的新发现,其余的可以归因于从进化论中获得的新观点的结合。简而言之,抑郁症比以前认识到的要普遍得多,其中大部分病例涉及的个体没有继续复发。非精神病性单相抑郁症(但不是双相躁狂症,这可能是一种“真正的”疾病)似乎是一种适应,其进化目的是促进反思,以解决我们祖先过去的复杂社会问题。认知行为疗法似乎结构了沉思,这样复发风险升高的患者就不会因为自己的不幸而“陷入困境”,而抗抑郁药物可能以延长基础发作为代价来抑制症状,因此每当患者尝试停止治疗时,其复发风险仍然升高.这意味着没有其他复发风险的患者可以服用他们不需要的药物,并且无论他们是否需要,都可以无限期地服用。
    The paradigm is shifting with respect to how we think about depression and its treatment. Some of that shift can be attributed to new findings with respect to its epidemiology and genetics and the rest can be attributed to the incorporation of a new perspective derived from evolutionary theory. In brief, depression is far more prevalent than previously recognized with the bulk of additional cases involving individuals who do not go on to become recurrent. Nonpsychotic unipolar depression (but not bipolar mania which likely is a \"true\" disease) appears to be an adaptation that evolved to facilitate rumination in the service of resolving complex social problems in our ancestral past. Cognitive behavior therapy appears to structure that rumination so that patients at elevated risk for recurrence do not get \"stuck\" blaming themselves for their misfortunes, whereas antidepressant medications may suppress symptoms at the expense of prolonging the underlying episode such that patients remain at elevated risk for relapse whenever they try to discontinue. This means that patients not otherwise at risk for recurrence may be put on medications that they do not need and kept on them indefinitely whether they need to be or not.
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