背景:可卡因使用(CU)在HIV(PWH)患者中很普遍。这两种情况都与认知功能和神经网络拓扑的变化有关。本研究利用图论研究与HIV和CU相关的功能连接组学,专注于被称为集线器的密集连接节点的中断。
方法:分析了206名成年人(年龄22-55岁)的静息状态功能磁共振成像(fMRI)。对四组参与者实施了HIVxCU因子设计:HIV+CU(n=41),仅HIV(n=88),仅CU(n=36),和控制(n=41)。功能性连接体被构建,并计算了阈值图度量。网络中心性度量-介数中心性(BC),参与系数(PC),并在模块度(WD)内-被量化为集线器破坏指数(HDI)。对于每个索引,进行2×2ANCOVA控制教育。
结果:参与者为68%的男性和74%的非洲裔美国人,平均年龄为44.4岁。在所有三个指标中,HIV和CU与枢纽中断有关。对于HDI-PC和HDI-WD,这样,HIV疾病与没有CU的参与者中更大的枢纽中断有关,但不是在CU参与者之间。总的来说,在所有三个指标上,较低的整体认知功能与较大的中枢中断相关.
结论:在HIV疾病和CU,突出显示两种具有神经认知效应的疾病的拓扑重组。与集线器相关的措施告知HIV疾病和CU的功能连接中断,特别是关于整个连接体网络拓扑的变化。
BACKGROUND: Cocaine use (CU) is prevalent in people with HIV (PWH). Both conditions are linked to changes in cognitive functioning and neural network topology. The current study utilizes graph theory to investigate functional connectomics associated with HIV and CU, focusing on disruption of densely connected nodes called hubs.
METHODS: Resting state functional magnetic resonance imaging (fMRI) from 206 adults (ages 22-55 years) were analyzed. A HIV x CU factorial design was implemented with participants in four groups: HIV+CU (n= 41), HIV only (n= 88), CU only (n= 36), and controls (n= 41). Functional connectomes were constructed, and thresholded graph metrics were calculated. Network centrality metrics - betweenness centrality (BC), participation coefficient (PC), and within module degree (WD) - were quantified into hub disruption indices (HDI). For each index, a 2×2 ANCOVA was performed controlling for education.
RESULTS: Participants were 68 % male and 74 % African-American with a mean age of 44.4 years. HIV and CU were associated with hub disruption in all three indices. Interactions were significant for HDI-PC and HDI-WD, such that HIV disease was associated with greater hub disruption among participants without CU, but not among participants with CU. Overall, lower global cognitive functioning was associated with greater hub disruption on all three indices.
CONCLUSIONS: Widespread hub disruption was evident in HIV disease and CU, highlighting topological reorganization in both diseases with neurocognitive effects. Hub-related measures inform functional connectivity disruptions in HIV disease and CU, particularly with respect to changes in network topology throughout the connectome.