背景:糖尿病,与多种器官功能障碍相关的高血糖状况,是代谢紊乱的标志.这种危及生命的疾病影响着全球数百万人,在经济上伤害他们,治疗过程中的身体和心理。
目的:由于最近的技术进步和见解,疾病的疗程疗法经历了突破性的转变。或者,使用降低高血糖的药物会导致多种并发症,包括严重的心血管疾病,肾衰竭,肝脏问题,和几种皮肤病。考虑具有最小副作用或没有不良反应的替代糖尿病治疗是由这些问题驱动的。
方法:在PubMed等权威科学数据库中进行了广泛的文献研究,Scopus,和WebofScience确定阐明萜类化合物在糖尿病中的生物活性的研究。
方法:包括\'萜类化合物\',\'单萜\',\'二萜\',\'倍半萜\',\'糖尿病\',“糖尿病”,\'临床试验\',\'临床前研究\',和“血糖升高”用于鉴定相关研究文章。排除标准,比如英语,重复,开放访问,仅抽象,以及不涉及临床前和临床研究的研究,设置。基于这些标准,选择937篇相关文章进行进一步评估。
结果:三萜可以作为糖尿病视网膜病变的治疗药物,周围神经病变,通过抑制与高血糖及其并发症相关的几种途径而导致肾功能障碍。因此,必须特别注意这些化合物的治疗效果,并为科学专业人员提供新的数据。
结论:本研究阐述了萜类化合物作用机制研究的最新进展。它的副产品,生理行为,和治疗应用,特别是在糖尿病和相关疾病中。
BACKGROUND: Diabetes mellitus, a hyperglycemic condition associated with multitudinous organ dysfunction, is a hallmark of the metabolic disorder. This life-threatening condition affects millions of individuals globally, harming them financially, physically and psychologically in the course of therapy.
OBJECTIVE: The course therapy for illnesses has undergone ground-breaking transformations due to recent technical advances and insights. Alternatively, the administration of hyperglycemia-reducing agents results in several complications, including severe cardiovascular disease, kidney failure, hepatic problems, and several dermatological conditions. Consideration of alternate diabetic therapy having minimal side effects or no adverse reactions has been driven by such problems.
METHODS: An extensive literature study was conducted in authoritative scientific databases such as PubMed, Scopus, and Web of Science to identify the studies elucidating the bioactivities of terpenoids in diabetic conditions.
METHODS: Keywords including \'terpenoids\', \'monoterpenes\', \'diterpenes\', \'sesquiterpenes\', \'diabetes\', \'diabetes mellitus\', \'clinical trials\', \'preclinical studies\', and \'increased blood glucose\' were used to identify the relevant research articles. The exclusion criteria, such as English language, duplication, open access, abstract only, and studies not involving preclinical and clinical research, were set. Based on these criteria, 937 relevant articles were selected for further evaluation.
RESULTS: Triterpenes can serve as therapeutic agents for diabetic retinopathy, peripheral neuropathy, and kidney dysfunction by inhibiting several pathways linked to hyperglycemia and its complications. Therefore, it is essential to draw special attention to these compounds\' therapeutic effectiveness and provide scientific professionals with novel data.
CONCLUSIONS: This study addressed recent progress in research focussing on mechanisms of terpenoid, its by-products, physiological actions, and therapeutic applications, particularly in diabetic and associated disorders.