芍药苷(PF),是白芍提取物的主要成分,是传统中药之一。与PF相关的药理作用包括抗氧化剂,免疫调节,抗炎,抗癌,抗抑郁和神经保护作用。我们先前的研究表明,PF通过抑制氧化应激(OS)保护黑素细胞并抑制光损伤。由于OS在各种疾病的进展中起着至关重要的作用,PF抑制OS的能力可能会对它们产生重要影响。然而,目前尚无关于PF与各种疾病相关的抗氧化作用的综述。因此,在这篇综述中,我们总结了与研究PF的抗氧化作用和分子机制有关的研究。通过其抑制OS的能力,PF已被证明对几个系统产生有益的影响,包括神经,心脏/血管,消化性,和呼吸系统疾病以及糖尿病等特定疾病,自身免疫,怀孕相关,眼,肾,皮肤病学,随着远端皮瓣坏死的抑制,术后粘连,和听力损失。这些发现为未来针对PF作为治疗临床疾病的天然抗氧化剂的发展提供了新的见解和方向。
Paeoniflorin (PF), which is the main component of the Paeonia lactiflora Pall extract, is one of the traditional Chinese medicines. The pharmacological effects associated with PF include antioxidant, immunomodulatory, anti-inflammatory, anticancer, antidepressant-like and neuroprotective effects. Our previous studies had revealed that PF protected melanocytes and inhibited photodamage through the suppression of oxidative stress (OS). As OS plays a vital role in the progression of a variety of diseases, the capacity for PF to suppress OS may exert important effects upon them. However, no review exists on these antioxidant effects of PF as related to various diseases. Therefore, in this review we summarized studies involved with examining the antioxidant effects and molecular mechanisms of PF. Through its capacity to inhibit OS, PF has been shown to exert beneficial effects upon several systems including nervous, cardiac/vascular, digestive, and respiratory as well as specific diseases such as diabetes, autoimmune, pregnancy related, ocular, kidney, dermatology, along with suppression of distal flap necrosis, postoperative adhesions, and hearing loss. Such findings provide new insights and directions for future research directed at the development of PF as a natural antioxidant for the treatment of clinical diseases.