苯丁酸氮芥(CML)治疗慢性淋巴细胞白血病(白细胞癌)。高剂量的CML会引起多种副作用,如骨髓抑制,贫血,周围神经病变,和人体内的不孕症。在这项研究中,我们合成了一种基于掺杂铜的二氧化钛(CuTiO2)和二维六方氮化硼(CuTiO2@BN)的纳米复合材料,用于CML的高效电化学检测。一系列表征技术FT-IR,XRD,拉曼光谱,SEM,TEM,EDAXXPS,并通过电化学表征分析了CuTiO2@BN纳米复合材料的结构和形貌组成。已使用伏安法评估了CuTiO2@BN修饰的GCE用于CML检测的传感性能。计时电流技术分析了CML在CuTiO2@BN/GCE上的电化学氧化动力学。CuTiO2@BN基玻碳电极(GCE)由于其许多活性位点,对CML氧化具有协同电催化作用,增加表面积,快速电荷转移,和许多缺陷。对于CML的检测,提出的电化学传感器具有优异的选择性,低检测限(LOD)为5.0nM,宽线性范围(0.02-8000µM),和快速反应时间。
Chlorambucil (CML) cures chronic lymphatic leukemia (white blood cell cancer). A high dose of CML can cause several side effects like bone marrow suppression, anemia, peripheral neuropathy, and infertility in the human body. In this research, we have synthesized a nanocomposite based on copper-doped titanium dioxide (CuTiO2) adorned with 2D hexagonal boron nitride (CuTiO2@BN) for the efficient electrochemical detection of CML. A series of characterization techniques FT-IR, XRD, Raman spectroscopy, SEM, TEM, EDAX XPS, and electrochemical characterization were used to analyze the CuTiO2@BN nanocomposite structural and morphological compositions. The sensing performance of the CuTiO2@BN modified GCE for CML detection has been assessed using voltammetry methods. The
chronoamperometry technique analyzed the kinetics of the electrochemical oxidation of CML at CuTiO2@BN/GCE. The CuTiO2@BN-based glassy carbon electrode (GCE) has a synergetic electro-catalytic effect on CML oxidation due to its many active sites, enhanced surface area, fast charge transfer, and numerous defects. For the detection of CML, the suggested electrochemical sensor exhibits excellent selectivity, low limit of detection (LOD) as found 5.0 nM, wide linear ranges (0.02-8000 µM), and quick reaction times.