慢性复发性膀胱炎(CRC)是女性人群中的常见疾病,也是严重的医学问题。没有足够的数据来说明这种症状的病因和有效的治疗方法。
提高细菌性和乳头状瘤病毒慢性复发性膀胱炎鉴别诊断的准确性。
118例CRC患者的内镜和形态学诊断方法分析,which,根据病因,分为两组。I组(n=65)HPV病因学CRC和II组(n=53)-细菌病因学CRC(E.大肠杆菌)。所有患者均根据EAU和RSU建议进行检查,并且还包括膀胱内窥镜检查(膀胱镜检查),然后对膀胱活检标本进行形态学检查。
细菌性CRC的内镜图像通常是由膀胱粘膜充血引起的,充血和注射血管,参与(小穿刺/透析)出血,没有增殖变化的迹象。所有患者表现为局灶性或弥漫性乳头状瘤病毒CRC的内镜图像,稍微升高,外生性,通常发白或发白灰色的息肉状结构,通常位于莱托三角形。对细菌性膀胱炎患者膀胱黏膜层和黏膜下层活检组织的形态学分析表现为水肿,尿路上皮增厚,毛细血管丰度,炎性浸润,以淋巴细胞为代表,浆细胞和白细胞,其中以嗜中性巨噬细胞白细胞为主。所有检查的患者的膀胱粘膜的形态学分析HPV相关病变的迹象显示尿路上皮增厚,尿路上皮鳞状上皮化生,慢性炎症,微循环血管反应和水肿。膀胱内HPV的一个重要的独特病理形态学标志是由于病毒的细胞病变作用而存在尿路上皮细胞的空细胞转化。
乳头状瘤病毒CR的特征是膀胱壁的感染-炎症过程,伴有淋巴细胞-血浆浸润和尿路上皮的胞浆转化。
Chronic recurrent cystitis (CRC) is a common disease in the female population and a serious medical problem. There are not enough data about etiology of this desiase and effective treatment.
To increase the accuracy of the differential diagnosis of bacterial and papillomavirus chronic recurrent cystitis.
Analysis of endoscopic and morphological diagnostic methods of 118 patients with CRC, which, depending on the etiological factor, were divided into two groups. Group I (n=65) patients with CRC of HPV etiology and Group II (n=53) - CRC of bacterial etiology (E. coli). All patients were examined according to the EAU and RSU recommendations, and an endoscopic examination of the bladder (cystoscopy) was additionally included, followed by morphological examination of biopsy specimen of the urinary bladder.
The endoscopic picture of bacterial CRC usually is caused by hyperemia of the mucous membrane of the bladder, hyperemia and injection of vessels with the participation of (small-puncture/diapedesic) hemorrhages without signs of proliferative changes. The endoscopic picture in papillomavirus CRC in all patients presented by focal or diffuse, slightly elevated, exophytic, often polypoid formations of a whitish or whitish-gray color, usually localized in the Leto triangle. Morphological analysis of biopsy tissue of the urinary bladder in patients with bacterial cystitis in the mucous and submucous layer showed edema, thickening of the urothelium, capillary abundance, inflammatory infiltration, represented by lymphocytes, plasma cells and leukocytes, among which neutrophilic macrophage leukocytes were predominant. Morphological analysis of the bladder mucosa in all examined patients with signs of HPV-related lesions showed a thickening of the urothelium, squamous metaplasia of the urothelium, chronic inflammation, microcirculatory vascular reaction and edema. An important distinctive pathomorphological sign of HPV within urinary bladder was the presence of koilocytic transformation of urothelium cells due to the cytopathic effect of the virus.
Papillomavirus CR has characterized by an infectious-inflammatory process in the bladder paries, with lymphocytic-plasmatic infiltration and coylocytic transformation of the urothelium.