■甲状腺激素(THs)在调节各种生物过程中起着至关重要的作用,特别是中枢神经系统(CNS)的正常发育和功能。癫痫是一种常见的神经系统疾病,具有多种病因。有必要进一步深入研究甲状腺激素在癫痫中的作用。
■甲状腺功能和癫痫的全基因组关联研究(GWAS)数据来自甲状腺组学协会和国际抗癫痫联盟(ILAE)协会,分别。共纳入5项甲状腺功能指标和10种癫痫类型的分析。进行了两个样本孟德尔随机化(MR)分析,以研究甲状腺功能与各种癫痫之间的潜在因果关系。使用Bonferroni校正进行多次测试校正。用Cochran的Q统计检验计算异质性。通过MR-Egger回归截距评估水平多效性。敏感性也通过留一策略进行了检查。
■研究结果表明,甲状腺激素异常与各种类型的癫痫之间没有任何因果关系。该研究分析了甲状腺激素与不同类型癫痫在5种情况下的比值比(OR),包括游离甲状腺素(FT4)对局灶性癫痫伴海马硬化(IVW,OR=0.9838,p=0.02223),青少年失神癫痫的甲状腺功能亢进(IVW,OR=0.9952,p=0.03777),局灶性癫痫伴海马硬化的甲状腺功能减退症(IVW,OR=1.0075,p=0.01951),自身免疫性甲状腺疾病(AITDs)在所有文献记载的病例中对全身性癫痫的影响(加权模式,OR=1.0846,p=0.0346)和儿童失神癫痫(IVW,OR=1.0050,p=0.04555)。Bonferroni校正后,上述结果均无统计学差异。
■这项研究表明,甲状腺相关疾病与各种类型的癫痫之间没有因果关系。未来的研究应旨在避免可能影响研究的潜在混杂因素。
UNASSIGNED: Thyroid hormones (THs) play a crucial role in regulating various biological processes, particularly the normal development and functioning of the central nervous system (CNS). Epilepsy is a prevalent neurological disorder with multiple etiologies. Further in-depth research on the role of thyroid hormones in epilepsy is warranted.
UNASSIGNED: Genome-wide association study (GWAS) data for thyroid function and epilepsy were obtained from the ThyroidOmics Consortium and the International League Against Epilepsy (ILAE) Consortium cohort, respectively. A total of five indicators of thyroid function and ten types of epilepsy were included in the analysis. Two-sample Mendelian randomization (MR) analyses were conducted to investigate potential causal relations between thyroid functions and various epilepsies. Multiple testing correction was performed using Bonferroni correction. Heterogeneity was calculated with the Cochran\'s Q statistic test. Horizontal pleiotropy was evaluated by the MR-Egger regression intercept. The sensitivity was also examined by leave-one-out strategy.
UNASSIGNED: The findings indicated the absence of any causal relationship between abnormalities in thyroid hormone and various types of epilepsy. The study analyzed the odds ratio (OR) between thyroid hormones and various types of epilepsy in five scenarios, including free thyroxine (FT4) on focal epilepsy with hippocampal sclerosis (IVW, OR = 0.9838, p = 0.02223), hyperthyroidism on juvenile absence epilepsy (IVW, OR = 0.9952, p = 0.03777), hypothyroidism on focal epilepsy with hippocampal sclerosis (IVW, OR = 1.0075, p = 0.01951), autoimmune thyroid diseases (AITDs) on generalized epilepsy in all documented cases (weighted mode, OR = 1.0846, p = 0.0346) and on childhood absence epilepsy (IVW, OR = 1.0050, p = 0.04555). After Bonferroni correction, none of the above results showed statistically significant differences.
UNASSIGNED: This study indicates that there is no causal relationship between thyroid-related disorders and various types of epilepsy. Future research should aim to avoid potential confounding factors that might impact the study.