child development

儿童发展
  • 文章类型: Journal Article
    资源不足已被确定为导致与被监禁母亲生活在一起的儿童在所有领域的发育延迟的重要因素。往往缺乏大家庭的支持,这些孩子经历类似于监禁的环境,缺乏必要的认知,社会,和情绪刺激对他们的发展至关重要。这种剥夺可能导致严重的教育挫折,并阻碍他们的社会融合。这篇评论旨在研究监狱环境对与被监禁母亲一起居住的儿童发育的影响。当前的研究强调了有关这些儿童发育路径的全面数据的明显缺乏。一些研究表明,监狱托儿所可能会培养积极的代际依恋,有可能减轻在产妇分离情况下观察到的典型低弹性。然而,虽然低阶认知功能可能不会表现出明显的延迟,高阶思维能力的发展提出了更大的挑战。解决儿童在监狱环境中面临的发展风险至关重要,考虑到他们更容易受到系统性忽视。因此,优先考虑最佳儿童发展对于确保这些儿童实现其里程碑至关重要。
    Insufficient resources have been identified as a significant factor contributing to delayed development across all domains for children living with their incarcerated mothers. Often lacking extended family support, these children experience environments resembling confinement, devoid of essential cognitive, social, and emotional stimuli crucial for their development. This deprivation can result in substantial educational setbacks and hinder their social integration. This review aims to examine the impact of the prison environment on the development of children residing with their incarcerated mothers. Current research underscores a notable scarcity of comprehensive data on the developmental paths of these children. Some studies suggest that prison nurseries may cultivate positive intergenerational attachments, potentially mitigating the typically low resilience observed in cases of maternal separation. However, while lower-order cognitive functions may not exhibit significant delays, the development of higher-order thinking skills presents more considerable challenges. Addressing the developmental risks faced by children in prison settings is critical, given their heightened vulnerability to systemic neglect. Therefore, prioritizing optimal child development is essential to ensure these children achieve their milestones.
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  • 文章类型: Journal Article
    亲社会行为是人性的显著特征。虽然亲社会行为出现在发展的早期,背景因素在这些行为如何在发展过程中表现出重要作用。大量的研究侧重于跨不同文化的亲社会发展的轨迹,并调查促进它的背景。在这种发展研究努力理解和加强人类合作方面的背景下,对于被迫逃离暴力冲突的儿童来说,深刻的负面力量对社会情感发展的灾难性影响。近50万罗兴亚儿童,他们的家人被迫逃离缅甸的种族灭绝,现在住在世界上最大的难民营。考察人类亲社会面对极端逆境时的韧性,我们记录了生活在大型营地中的罗兴亚难民儿童的最初亲社会水平(考克斯·巴扎尔,孟加拉国)以及在旨在促进亲社会的多方面干预后这些水平得到改善的程度。这项研究是罗兴亚社区成员与生活经验之间的伙伴关系,人道主义从业者,和发展研究人员。152名罗兴亚儿童(5-12岁)的样本参与了亲社会行为和相关认知情感过程的干预前后评估。罗兴亚研究人员在2021年11月至2022年1月之间实施了为期10天的基于合作的干预措施。出生地被用作创伤水平的替代度量。在缅甸出生的儿童(N=88)直接经历了相对较高水平的创伤(种族灭绝,强迫移民)比家人逃离缅甸后在营地出生的儿童(N=64)。用任务电池在干预前后对儿童进行了单独测试,包括一个帮助(折纸)和两个共享任务(独裁者游戏[DG],强迫选择分享)衡量亲社会行为。对相关认知情感过程的评估包括故事任务中的移情反应和情感视角的测量(想象一下,判断)和执行功能(EF)技能(较年轻:Hearts&Flowers;较大:尺寸变化卡排序)。为期10天的小组干预会议针对这些亲社会行为和认知情感过程,并基于协作活动,在整个干预阶段,与同一伙伴一起接受情感观点和EF技能培训。我们使用潜在变化模型来检查从干预前到干预后这些措施的初始水平(干预前)和与干预相关的变化。在所有措施(干预前)中都发现了亲社会反应,在大多数措施中都有明显的改善(干预前后的变化)。年龄和出生地变量是初始水平和干预相关变化的重要预测因子。初始水平:关于年龄,年龄较大的儿童(9-12岁)在强迫选择任务中的分享水平高于年龄较小的儿童(5-8岁),但在DG中的分享水平较低。当被要求报告他们在想象任务中对另一个人的不幸的感受和反应时,年龄较大的孩子也表现出更高的同理反应。关于出生地,在干预之前,营地出生的儿童比缅甸出生的儿童在折纸任务中的帮助水平更高,并报告了更多的行为反应,表明他们将如何应对想象任务中的不幸。相比之下,缅甸出生的儿童在DG中的分享水平更高,并且在强迫选择分享任务中始终选择平等而不是不平等,即使他们的伴侣会得到更多,表明了这些孩子的慷慨模式。根据EF措施,缅甸出生的儿童的水平低于营地出生的儿童。干预相关的变化:关于年龄,年龄较大但不是较小的孩子更有可能在干预后的强迫选择共享任务中增加平等的选择,而不是不平等。关于出生地和帮助,营地出生的孩子增加了帮助他们的伴侣折纸塑造自己的行为(“如何”帮助),而缅甸出生的孩子增加了为他们的伴侣接管折叠的行为(“为帮助”)。对于共享任务,缅甸出生但不是营地出生的儿童在DG中的分享增加,并在强迫选择分享任务中表现出更多的慷慨模式。在想象故事任务中,在缅甸出生的孩子比在营地出生的孩子更有可能增加同理反应(即,想象他们的感受)。在缅甸出生的儿童在EF措施方面的改善少于在营地出生的儿童。一起来看,这些发现提供了证据,在极端逆境的背景下,罗兴亚儿童表现出亲社会,并从多方面的干预中受益。我们的研究增加了这样一种观点,即人类的亲社会是人类的基本特征,不仅可以生存,而且可以在最不利的童年环境中得到增强。我们多方面的干预,这是在协作的社会背景下实施的,有针对性的亲社会行为和相关的认知情感过程,旨在在难民背景下的现有心理社会支持计划中轻松实施。随着受暴力冲突和被迫移徙影响的儿童人数在世界范围内惊人地增加,迫切需要扩大研究伙伴关系,以改善这数百万儿童的发展成果。
    Prosocial behavior is a distinguishing characteristic of human nature. Although prosocial behaviors emerge early in development, contextual factors play an important role in how these behaviors are manifested over development. A large body of research focuses on the trajectory of prosocial development across diverse cultures and investigating contexts that foster it. Against this backdrop of developmental research endeavoring to understand and enhance the cooperative side of humanity, is the catastrophic impact of profoundly negative forces on social-emotional development for children forced to flee from violent conflict. Close to half a million Rohingya children, whose families were forced to flee genocide in Myanmar, now live in the largest refugee camp in the world. To examine the resilience of human prosociality in the face of extreme adversity, we documented initial levels of prosociality in Rohingya refugee children living in a mega-camp (Cox\'s Bazar, Bangladesh) and the extent to which those levels were improved following a multifaceted intervention designed to foster prosociality. The research was a partnership between Rohingya community members with lived experience, humanitarian practitioners, and developmental researchers. A sample of 152 Rohingya children (5-12 years) participated in pre- and postintervention assessments of prosocial behaviors and related cognitive-affective processes. The 10-day collaboration-based intervention was implemented between November 2021 and January 2022 by Rohingya researchers. Birthplace was used as a proxy measure of trauma level. Children born in Myanmar (N = 88) directly experienced relatively higher levels of trauma (genocide, forced migration) than children who were born in the camp after their families fled from Myanmar (N = 64). Children were individually tested pre- and postintervention with a task battery, including a helping (Origami) and two sharing tasks (Dictator Game [DG], Forced Choice sharing) measuring prosocial behavior. Assessments of related cognitive-affective processes included measures of empathic responding and emotion perspective-taking in story tasks (Imagine, Judgment) and executive function (EF) skills (Younger: Hearts & Flowers; Older: Dimensional Change Card Sorting). Small group intervention sessions conducted over 10 days targeted these prosocial behaviors and cognitive-affective processes and were based on collaborative activities, emotion perspective taking and EF skills training with the same partner throughout the intervention phase. We used latent change modeling to examine initial levels (preintervention) and intervention-related changes in these measures from pre- to postintervention. Prosocial responding was found across all measures (preintervention) and improvements (pre- to postintervention change) were apparent across most measures. Age and birthplace variables were significant predictors of initial levels and intervention-related change. Initial levels: Regarding age, older children (9-12 years) showed higher levels than younger children (5-8 years) of sharing in the Forced Choice task but lower levels in the DG. Older children also showed higher levels of empathic responding when asked to report how they would feel and respond to another person\'s misfortune in the Imagine task. Regarding birthplace, prior to the intervention camp-born children showed higher levels than Myanmar-born children of helping in the Origami task and reported more behavioral responses indicating how they would respond to misfortune in the Imagine task. In contrast, Myanmar-born children had higher levels of sharing in the DG and consistently chose equality over inequality in the Forced Choice sharing task, even when their partner would receive more, indicating a pattern of generosity in these children. Myanmar-born children had lower levels than camp-born children on EF measures. Intervention-related change: Regarding age, older but not younger children were more likely to increase choices for equality over inequality on the Forced Choice sharing task following the intervention. Regarding birthplace and helping, camp-born children increased behaviors that helped their partner make origami shapes themselves (\"how-to\" helping), whereas Myanmar-born children increased behavior that took over folding for their partner (\"do-for\" helping). For sharing tasks, Myanmar-born but not camp-born children increased sharing in the DG and showed an increased pattern of generosity in Forced Choice sharing task. In the Imagine story task, children born in Myanmar were more likely than those born in camp to increase empathic responding (i.e., imagining how they would feel). Children born in Myanmar showed less improvement on EF measures than children born in the camp. Taken together, these findings provide evidence that in a context of extreme adversity, Rohingya children exhibited prosociality and benefitted from a multifaceted intervention. Our research adds credence to the view that human prosociality is a fundamental characteristic of humanity that not only survives but can be enhanced in even the most adverse of childhood environments. Our multifaceted intervention, which was implemented within a collaborative social context and targeted prosocial behaviors and related cognitive-affective processes, was designed to be easily implemented within existing psychosocial support programs in refugee contexts. As the numbers of children affected by violent conflict and forced migration rise alarmingly worldwide, there is a critical need to expand research partnerships that aim to improve developmental outcomes for these millions of children.
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  • 文章类型: Journal Article
    这篇评论讨论了多动症的历史,以及它如何为当代关于这种疾病的辩论提供信息。它批评多动症的回顾性历史,它提出了这种疾病的早期起源,而不是与历史证据相匹配。结论是指出ADHD何时确实出现为一种独特的疾病,以及为什么这样做。
    This commentary discusses the history of ADHD and how it can inform contemporary debates about the disorder. It critiques retrospective histories of ADHD, which propose earlier origins for the disorder than match the historical evidence. It concludes by indicating when ADHD did emerge as a distinctive disorder and why it did so.
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  • 文章类型: Journal Article
    背景:支持幼儿父母的干预措施通常分别针对育儿或父母的心理健康。多组分育儿和父母心理健康干预措施有可能改善育儿实践,心理健康,和早期儿童发展。我们旨在研究它们对儿童和父母结局的影响。
    方法:在本系统综述和荟萃分析中,我们搜索了MEDLINE,Embase,WebofScience核心合集,APAPsycINFO,CINAHL完成,Cochrane中央受控试验登记册,和全球卫生数据库从成立到2024年1月23日。符合条件的研究是针对父母行为和父母心理健康的干预措施的随机对照试验。筛选,提取,质量评估由两名作者独立完成.主要结果是儿童的认知和社会情绪功能和父母的抑郁症状,荟萃分析为标准化平均差异(SMD),相对于控制。这项研究在PROSPERO注册,CRD42022302848。
    结果:我们发现了5843条记录。在筛选2636(45%)标题和摘要后,我们手动识别并筛选了另外3篇文章,排除了2177条记录.在筛选了462篇全长文章后,25条,代表8520名儿童和照顾者的样本量,包括在内。在基线,平均照顾者年龄为27·7岁(SD5·9),平均儿童年龄(不包括怀孕期间登记的儿童)为14·4个月(8·0).干预平均持续14个月(SD11),并使用了3·7种行为改变技术(2·0)。大多数干预措施将更多的时间用于育儿行为,而不是父母的心理健康。我们发现干预对儿童的认知(SMD0·19[95%CI0·04至0·34];I2=69%)和社交情感(0·26[0·17至0·34];I2=47%)结果具有显着的影响,但对女性护理人员的抑郁症状没有影响(-0·18[-0·36至0·002];I2=86%)。所有研究的偏差风险是中等的,我们发现了不同结果的异质性。
    结论:多组分育儿和心理健康干预对儿童认知和社会情绪结果有积极影响,但不是父母的抑郁症状,提示其他因素可能有助于积极的ECD结果。干预措施可能缺乏对心理健康的足够关注,无法产生明显的影响,强调需要未来的研究来区分和评估育儿和心理健康组成部分的贡献,以了解对家庭结果的独立和集体影响。
    背景:加拿大卫生研究院。
    BACKGROUND: Interventions supporting parents of young children often target parenting or parental mental health separately. Multi-component parenting and parental mental health interventions have the potential to improve parenting practices, mental health, and early childhood development. We aimed to examine their impact on child and parent outcomes.
    METHODS: In this systematic review and meta-analysis, we searched MEDLINE, Embase, Web of Science Core Collection, APA PsycINFO, CINAHL Complete, the Cochrane Central Register of Controlled Trials, and the Global Health Database from inception to Jan 23, 2024. Eligible studies were randomised controlled trials of interventions explicitly targeting parenting behaviours and parental mental health antenatally or in children\'s first 3 years of life. Screening, extraction, and quality assessment were done independently by two authors. Primary outcomes were cognitive and social-emotional functioning in children and depressive symptoms in parents, meta-analysed as standardised mean differences (SMDs), relative to control. This study is registered with PROSPERO, CRD42022302848.
    RESULTS: We found 5843 records. After screening 2636 (45·1%) titles and abstracts, we manually identified and screened three additional articles and excluded 2177 records. After screening 462 full-length articles, 25 articles, representing a sample size of 8520 children and caregivers, were included. At baseline, mean caregiver age was 27·7 years (SD 5·9) and mean child age (excluding those enrolled during pregnancy) was 14·4 months (8·0). Interventions lasted a mean of 14 months (SD 11) and used a mean of 3·7 behaviour change techniques (2·0). Most interventions dedicated more time to parenting behaviours than to parental mental health. We found significant intervention effects on children\'s cognitive (SMD 0·19 [95% CI 0·04 to 0·34]; I2=69%) and social-emotional (0·26 [0·17 to 0·34]; I2=47%) outcomes but not on depressive symptoms in female caregivers (-0·18 [-0·36 to 0·002]; I2=86%) relative to control conditions. Risk of bias across studies was moderate, and we found heterogeneity across results.
    CONCLUSIONS: Multi-component parenting and mental health interventions had a positive effect on child cognitive and social-emotional outcomes, but not on depressive symptoms in parents, suggesting that other factors might contribute to positive ECD outcomes. Interventions might lack adequate focus on mental health to make a discernible impact, highlighting a need for future studies to differentiate and assess contributions of parenting and mental health components to understand independent and collective effects on family outcomes.
    BACKGROUND: Canadian Institutes of Health Research.
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  • 文章类型: Journal Article
    从童年到成年,多感觉统合(MSI)经历了长期的成熟,这是公认的。然而,现有证据可能被潜在的与年龄相关的注意力差异所混淆.揭示MSI的神经发育变化,同时匹配儿童和成人之间自上而下的关注,我们在视觉-听觉注意传播范式中记录了7至9岁健康儿童和年轻人的事件相关电位,其中注意力和MSI可以同时测量.儿童与成年人在视觉选择消极性成分和听觉干扰行为测量方面的差异首先表明,儿童组可以保持自上而下的视觉注意力,而忽略与任务无关的听觉信息的程度与成年人相似。然后,通过听觉负差(Nd)成分量化的刺激驱动的注意力传播在儿童组中总体上不存在,揭示了孩子们在很大程度上不成熟的视听绑定过程。这些发现为MSI本身从童年到成年的长期成熟提供了强有力的证据,从而为表征MSI的发展历程提供了新的基准。此外,我们还发现,由另一种Nd测量的代表驱动的注意力传播在儿童中存在,但不那么健壮,表明他们基本上但没有完全发展的视听表示共激活过程。
    It is well-accepted that multisensory integration (MSI) undergoes protracted maturation from childhood to adulthood. However, existing evidence may have been confounded by potential age-related differences in attention. To unveil neurodevelopmental changes in MSI while matching top-down attention between children and adults, we recorded event-related potentials of healthy children aged 7 to 9 years and young adults in the visual-to-auditory attentional spreading paradigm wherein attention and MSI could be measured concurrently. The absence of children versus adults differences in the visual selection negativity component and behavioral measures of auditory interference first demonstrates that the child group could maintain top-down visual attention and ignore task-irrelevant auditory information to a similar extent as adults. Then, the stimulus-driven attentional spreading quantified by the auditory negative difference (Nd) component was found to be overall absent in the child group, revealing the children\'s largely immature audiovisual binding process. These findings furnish strong evidence for the protracted maturation of MSI per se from childhood to adulthood, hence providing a new benchmark for characterizing the developmental course of MSI. In addition, we also found that the representation-driven attentional spreading measured by another Nd was present but less robust in children, suggesting their substantially but not fully developed audiovisual representation coactivation process.
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  • 文章类型: Journal Article
    人类的发展受到生物和社会因素相互作用的影响。本研究旨在验证社会风险对生物风险与儿童发育关系的调节作用。收集了201名儿童的数据,6至72个月。自变量由生物风险指数衡量,社会风险指数的调节变量通过丹佛II检验进行评估。线性回归,效果大小,和适度分析用于验证BRI与儿童发育(丹佛II)之间的关系,和SRI的调节作用。BRI与儿童发育呈负相关,BRI和SRI之间的相互作用将丹佛II结果的解释方差增加到14%.SRI还是语言和GrossMotor领域的重要主持人。这项研究表明,社会风险调节了生物风险与儿童发育之间的关系,社会风险因素越多,这种关系变得越强。另一方面,可以说,一些社会因素有利于儿童的发展,即使存在生物危险因素。
    Human development is influenced by the interaction between biological and social factors. This study aimed to verify the moderating effect of social risk on the relationship between biological risk and child development. Data were collected on 201 children, aged 6 to 72 months. The independent variable was measured by the biological risk index, and the moderator variable by the social risk index was assessed by the Denver II test. Linear regression, effect size, and analysis of moderation were used to verify the relationship between BRI and the child development (Denver II), and the moderating effect of the SRI. BRI was negatively associated with child development, the interaction between the BRI and SRI increased the explained variance in the Denver II result to 14%. The SRI was also a significant moderator of the Language and Gross Motor domains. This research evidence that social risk moderates the relationship between biological risk and child development, the more social risk factors, the stronger this relationship becomes. On the other hand, it can be said that some social factors favor child development, even in the presence of biological risk factors.
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  • 文章类型: Journal Article
    目的:这是Cochrane审查(干预)的方案。目的如下:评估NICU中使用不同气味剂进行嗅觉刺激对促进早产儿发育和预防发病率的益处和危害。
    OBJECTIVE: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of olfactory stimulation with different odorants in the NICU for promoting development and preventing morbidity in preterm infants.
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  • 文章类型: Journal Article
    先前的研究表明,母亲的心理健康与婴儿发育之间存在着至关重要的联系。然而,对自主调节在产后产妇心理健康和婴儿结局中的作用了解有限。在目前的研究中,当婴儿3个月大时,我们检测了76个来自不同社会经济背景的母婴二元组.我们记录了二元组的同时ECG,而从婴儿收集了基线EEG;计算了ECG心率变异性(HRV)和EEGtheta-beta比率和alpha不对称性。还分析了二进生理同步性,以更好地了解自主神经共调节的作用。结果表明,较低的产妇HRV与较高的自我报告的产妇抑郁和焦虑相关。此外,HRV较低的母亲的婴儿HRV较低.母亲的HRV也与较高的婴儿theta-beta比率有关,但不是阿尔法不对称。探索性分析表明,对于具有更大生理同步性的母婴二元组,较高的母体HRV通过婴儿HRV预测婴儿theta-beta比增加。这些发现支持了一个模型,在该模型中,母亲的心理健康可能会通过自主神经应激调节和二元生理共同调节的改变来影响婴儿的神经生理学。
    Previous research has demonstrated a critical link between maternal mental health and infant development. However, there is limited understanding of the role of autonomic regulation in postpartum maternal mental health and infant outcomes. In the current study, we tested 76 mother-infant dyads from diverse socioeconomic backgrounds when infants were 3-months of age. We recorded simultaneous ECG from dyads while baseline EEG was collected from the infant; ECG heart rate variability (HRV) and EEG theta-beta ratio and alpha asymmetry were calculated. Dyadic physiological synchrony was also analyzed to better understand the role of autonomic co-regulation. Results demonstrated that lower maternal HRV was associated with higher self-reported maternal depression and anxiety. Additionally, mothers with lower HRV had infants with lower HRV. Maternal HRV was also associated with higher infant theta-beta ratios, but not alpha asymmetry. Exploratory analyses suggested that for mother-infant dyads with greater physiological synchrony, higher maternal HRV predicted increased infant theta-beta ratio via infant HRV. These findings support a model in which maternal mental health may influence infant neurophysiology via alterations in autonomic stress regulation and dyadic physiological co-regulation.
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  • 文章类型: Journal Article
    这项研究采用纵向分析来评估2019年冠状病毒病流行与神经发育之间的关系,方法是分析韩国国家健康筛查计划中包括的韩国婴幼儿发育筛查测试中的180万名儿童。我们比较了五个年龄组的发育结果-9-17个月,18-29个月,30-41个月,42-53个月,在大流行前(2018-2019年)和大流行(2020-2021年)之间的54-65个月。在通信大流行期间,观察到潜在的发育迟缓显着增加,认知,社交互动,自我照顾,以及大多数年龄组的精细运动技能。所有五个年龄组在沟通和精细运动技能方面都经历了明显的中断。来自社会经济弱势背景的儿童在所有领域都面临着更高的风险。这些发现强调了有针对性的干预措施和持续监测的必要性,以支持受流行病相关干扰影响的儿童的发展需求。
    This study employed a longitudinal analysis to evaluate the association between the coronavirus disease 2019 pandemic and neurodevelopment by analyzing over 1.8 million children from the Korean Developmental Screening Test for Infants and Children included in South Korea\'s National Health Screening Program. We compared the developmental outcomes in five age groups-9-17 months, 18-29 months, 30-41 months, 42-53 months, and 54-65 months-between the pre-pandemic (2018-2019) and pandemic (2020-2021) periods. Significant increases in potential developmental delays were observed during the pandemic in communication, cognitive, social interaction, self-care, and fine motor skills across most age groups. All five age groups experienced notable disruptions in communication and fine motor skills. Children from socioeconomically disadvantaged backgrounds faced higher risks across all domains. These findings highlight the need for targeted interventions and continuous monitoring to support the developmental needs of children affected by pandemic-related disruptions.
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  • 文章类型: Journal Article
    维生素A和D对孕妇和婴儿的健康至关重要。然而,脐带血维生素A和D水平与纯母乳喂养婴儿体格发育之间的关系仍不确定.
    这项队列研究旨在研究0-6个月纯母乳喂养婴儿的脐带血维生素A和D水平与身体发育之间的关系。
    总共招募了140对单胎母婴。问卷调查用于收集母婴信息,和液相色谱法用于定量脐带血中维生素A和D的水平。出生时进行人体测量,在3个月和6个月大的时候,和体重年龄z得分(WAZ),年龄长度z分数(LAZ),头围年龄z评分(HAZ),计算BMI与年龄相关的z评分(BMIZ)。使用单变量和多元线性回归模型进行分析。
    脐带血中维生素A和D的平均浓度为0.58±0.20μmol/L和34.07±13.35nmol/L,都低于正常范围的儿童。在调整混杂因素后,3~6月龄婴儿脐血维生素A水平与HAZ生长呈正相关(β=0.75,P<0.01),而维生素D水平与LAZ生长呈负相关(β=-0.01,P=0.01),与BMIZ生长呈正相关(β=0.02,P<0.01)。
    出生时较高的维生素A水平促进3-6个月婴儿的HAZ生长,而出生时较高的维生素D水平促进3-6个月婴儿的BMIZ生长。
    https://register。clinicaltrials.gov,标识符NCT04017286。
    UNASSIGNED: Vitamins A and D are essential for the health of pregnant women and infants. Nevertheless, the relationship between umbilical cord blood vitamins A and D levels and the physical growth of exclusively breastfed infants remains uncertain.
    UNASSIGNED: This cohort study aims to examine the relationship between cord blood vitamins A and D levels and the physical growth of exclusively breastfed infants aged 0-6 months.
    UNASSIGNED: 140 singleton mother-infant pairs were recruited in total. Questionnaires were used to collect maternal and infant information, and liquid chromatography was utilized to quantify the levels of vitamins A and D in the umbilical cord blood. Anthropometric measurements were conducted at birth, at 3 and 6 months of age, and the weight-for-age z-score (WAZ), length-for-age z-score (LAZ), head circumference-for-age z-score (HAZ), and BMI-for-age z-score (BMIZ) were calculated. Univariate and multivariate linear regression models were used for the analysis.
    UNASSIGNED: The average concentration of vitamins A and D in cord blood was 0.58 ± 0.20 μmol/L and 34.07 ± 13.35 nmol/L, both below the normal range for children. After adjusting for confounding factors, vitamin A levels in cord blood positively correlated with HAZ growth in infants aged 3-6 months (β= 0.75, P < 0.01) while vitamin D levels negatively correlated with LAZ growth (β= -0.01, P = 0.01) and positively correlated with BMIZ growth (β= 0.02, P < 0.01).
    UNASSIGNED: Higher Vitamin A levels at birth promote HAZ growth in infants aged 3-6 months while higher vitamin D levels at birth promote BMIZ growth in infants aged 3-6 months.
    UNASSIGNED: https://register.clinicaltrials.gov, identifier NCT04017286.
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