背景:Conioselinumanthriscoides(H.Boissieu)Pimenov&Kljuykov,又称川芎。是多年生伞形科草本植物,其干燥的根茎通常称为川芎。川芎在中医中应用广泛,特别是心脑血管和妇科疾病。然而,这些研究是分散的,没有评论可以集中这些研究的结果。作者通过收集有关化学,药理学,和川芎的毒理学在过去20年中发表在各种出版物上。
目的:本文旨在总结目前川芎的实验研究,探讨其作用机制。
方法:WebofScience,PubMed,CBM,CNKI,Medline,Embase,Elsevier,Springer,Wiley在线图书馆,学者,搜索了其他数据库,收集了近百项实验研究来总结这篇综述。
结论:川芎由精油组成,萜烯,生物碱,多糖,有机酸,神经酰胺,和脑苷脂。它具有促进血液循环的功能,祛瘀,抗菌,抗病毒,让头脑平静入睡。现在可用于治疗心脑血管和妇科疾病,神经退行性疾病,牛皮癣,直肠癌,骨质疏松,和骨关节炎。
结论:在过去的20年里,大量研究数据证实川芎含有丰富的有效代谢产物,具有巨大的药用潜力,并有广泛的有效治疗方法。
BACKGROUND: Conioselinum anthriscoides (H. Boissieu) Pimenov & Kljuykov, also known as Ligusticum chuanxiong Hort. is a perennial Umbelliferae herb, whose dried rhizome commonly called Chuanxiong Rhizoma. Chuanxiong Rhizoma is widely used in TCM, especially for cardiocerebrovascular and gynecological diseases. However, these studies are scattered and there is no review that can centralize the results of these studies. The authors summarized this review by collecting research results on the chemical, pharmacological, and toxicological of Chuanxiong Rhizoma published in various publications over the past 20 years.
OBJECTIVE: The purpose of this review is to summarize the current experimental studies on Chuanxiong Rhizoma and explore its mechanism of action.
METHODS: Web of Science, PubMed, CBM, CNKI, Medline, Embase, Elsevier, Springer, Wiley Online Library, Scholar, and other databases were searched, and nearly one hundred experimental studies were collected to summarize this review.
CONCLUSIONS: Chuanxiong Rhizoma is composed of essential oil, terpenes, alkaloids, polysaccharide, organic acids, ceramides, and cerebrosides. It has the functions of promoting blood circulation, removing blood stasis, antibacterial, antiviral, and calming the mind to sleep. Now it can be used to treat cardiocerebrovascular and gynecological diseases, neurodegenerative disease, psoriasis, rectal cancer, osteoporosis, and osteoarthritis.
CONCLUSIONS: In the past 20 years, a large number of research data have confirmed that Chuanxiong Rhizoma contains rich effective metabolites, has huge medicinal potential, and has a wide range of effective treatments.