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  • 文章类型: English Abstract
    分配是药剂师执行的任务中最需要和最重要的服务,在他的日常工作中,在社区药房。配药的目的是保证患者以充分和受控的方式获得药物。在这个过程中,社区药剂师有义务,作为一名医疗保健专业人士,以承诺的方式积极参与检测可能的药物或药物相关错误。SEFAC的患者安全小组已经发展,作为一系列未来项目的开始,作为透皮贴剂配制的药物的清单和最佳指南,改良释放形式或口腔分散片。这一举措的目的是尽可能减少,通过事先与病人面谈和使用这些工具,这些药物可能出现的任何错误或问题,从而确保患者安全。预计将在2023年与SEFAC患者安全小组合作的社区药房开始一个试点项目。因此,他们将能够收集和报告获得的结果。
    Dispensing is the most requested and important service within the tasks performed by the pharmacist, in his day-to-day work, in the community pharmacy. The aim of dispensing is to guarantee the patient\'s access to the medicine in an adequate and controlled manner. During that process, the community pharmacist has the obligation, as a healthcare professional, to actively participate in a committed manner in the detection of possible medication or medication-related errors.SEFAC´s patient safety group has developed, as the beginning of a series of future projects, checklists and best guidelines for medicines formulated as transdermal patches, modified release forms or orodispersible tablets. The aim of this initiative is to minimize as far as possible, by means of a prior interview with the patient and the use of these tools, any errors or problems that might arise with these drugs, thereby ensuring patient safety.A pilot project is expected to begin throughout 2023 in community pharmacies that collaborate with SEFAC\'s patient safety group. Therefore, they will be able to collect and report the results obtained.
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  • 文章类型: Journal Article
    背景:临床医生和研究人员应考虑干预措施的预期益处和潜在危害。育儿计划是针对儿童行为问题的广泛使用的基于证据的干预措施。然而,关于潜在负面影响的数据很少。本文的目的是增加育儿计划中不良事件(AE)评估的系统知识,并提供AE评估工具。
    方法:作为RISE项目(预防东南欧儿童心理健康问题-适应,优化,测试和延长父母的终身健康),我们在北马其顿为2至9岁儿童行为问题的父母的三项序贯研究中开发并测试了AE评估程序,摩尔多瓦共和国,和罗马尼亚。本文报告了第一阶段评估工具的开发(N=140),阶段2(N=835),以及在第3阶段使用优化程序的最终经验(多中心随机对照试验,N=823),其中之前评估了不良事件,在干预分娩期间三次,并在1年随访。在每个时间点,参与者完成了12项AE检查表.如果报告了父母或孩子的中度至重度问题,进行了结构化的后续访谈。
    结果:AE评估工具的反应率从6%(阶段1)增加到100%(阶段3),表明根据每个阶段的经验收集这些数据的情况有所改善。RCT(第3阶段)的结果显示,在最终优化的程序下,AE频率通常较低:在干预期间,没有记录严重不良事件(SAE);至少有一个AE报告了10%(在第一次会议之后),7%(第三届会议后),和4%(在上一届第五届会议之后)的参与者。已确定的(S)AE均与研究或干预无因果关系。需要考虑成本效益,以确定确保育儿计划参与者安全的最佳方法。
    结论:所应用的主动AE评估程序提供了一种全面的AE评估工具,可供其他人使用-适应特定环境,如果需要。根据我们的经验,我们概述了未来研究的建议.
    背景:ClinicalTrials.gov,注册号阶段1:NCT03552250;阶段2:NCT03865485;阶段3:NCT04721730。2021年1月13日注册
    BACKGROUND: Clinicians and researchers should consider the expected benefits and potential harms of an intervention. Parenting programmes are a widely used evidence-based intervention for child behaviour problems. However, few data are available on potential negative effects. The aims of this paper were to increase systematic knowledge of adverse event (AE) assessment in parenting programmes and to provide an AE assessment tool.
    METHODS: As part of the RISE project (prevention of child mental health problems in South-eastern Europe-adapt, optimise, test and extend parenting for lifelong health), we developed and tested an AE assessment procedure in three sequential studies for parents of children with child behaviour problems aged 2 to 9 years in North Macedonia, Republic of Moldova, and Romania. This paper reports on the development of the assessment tool in phase 1 (N = 140), phase 2 (N = 835), and the final experiences with using the optimised procedures in phase 3 (multisite randomised controlled trial, N = 823) in which AEs were assessed before, three times during intervention delivery, and at 1 year follow-up. At each time point, the participants completed a 12-item AE checklist. If moderate-to-severe problems of parent or child were reported, a structured follow-up interview was conducted.
    RESULTS: The response rate on the AE assessment tool increased from 6% (phase 1) to 100% (phase 3) indicating improvement in collecting these data based on the experiences of each phase. Results of the RCT (phase 3) showed generally low (S)AE frequencies with the finally optimised procedure: During the intervention, no serious adverse events (SAE) were registered; at least one AE was reported by 10% (after the first session), 7% (after the third session), and 4% (after the last fifth session) of participants. None of the identified (S)AEs was causally related to the study or intervention. Cost-benefit considerations are needed to determine the best way to ensure participant safety in parenting programmes.
    CONCLUSIONS: The applied active AE assessment procedure provides a comprehensive AE assessment tool that can be used by others-with adaptations for the specific context, if needed. Based on our experiences, we outline recommendations for future studies.
    BACKGROUND: ClinicalTrials.gov, registration number phase 1: NCT03552250; phase 2: NCT03865485, phase 3: NCT04721730 . Registered on 13 January 2021.
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  • 文章类型: Journal Article
    脂质组学研究的迅速增加导致了社区内部的合作努力,以建立生产的标准和标准,记录,和传播数据。创建一个易于使用的动态检查表,将有关脂质组学实验的关键信息浓缩为通用术语,将增强该领域的一致性,可比性,和可重复性。这里,我们描述了已建立的脂质组学最低报告清单的结构和原理,以提高脂质组学研究的透明度.
    The rapid increase in lipidomic studies has led to a collaborative effort within the community to establish standards and criteria for producing, documenting, and disseminating data. Creating a dynamic easy-to-use checklist that condenses key information about lipidomic experiments into common terminology will enhance the field\'s consistency, comparability, and repeatability. Here, we describe the structure and rationale of the established Lipidomics Minimal Reporting Checklist to increase transparency in lipidomics research.
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  • 文章类型: Journal Article
    钢琴家经常由于长时间坐着和笨拙的姿势而遭受姿势相关的问题。尽管与姿势相关的问题在钢琴家中很常见,作者只发现了一项研究,应用RULA评估钢琴家的姿势,无需对原始RULA工作表进行任何修改。其他现有文献都没有应用这种姿势评估工具来评估钢琴家的整体姿势。没有现有的快速上肢评估(RULA)清单,完全符合钢琴演奏的背景,至少没有一些修改。
    为了提出钢琴家快速上肢评估(RULA-p)的姿势评估,这将允许钢琴家在钢琴演奏过程中识别尴尬的姿势(如果有的话),因此,为了预防伤害,实现健康的游戏。
    这项研究修改了(i)肌肉使用评分;(ii)力/负荷评分,从现有的RULA作为钢琴家的姿势快速评估。
    以工作表格式为钢琴家(RULA-p)提出了修改后的RULA。
    总的来说,本研究旨在进一步扩展现有的钢琴家早期预防PRMD的文献。
    UNASSIGNED: Pianists often suffered from postural related problems due to prolonged sitting and awkward postures. Despite that postural related problems are common among pianists, there is only one study found by the authors, which applied RULA to assess pianists\' postures, without any modification to the original RULA worksheet. None of the other existing literature has applied this postural assessment tool to assess the pianists\' overall posture. There is no existing Rapid Upper Limb Assessment (RULA) checklist that exactly fits into the context of piano playing, at least not without some modifications.
    UNASSIGNED: To propose a Rapid Upper Limb Assessment for Pianists (RULA-p) for postural assessment, which will allow pianists to identify awkward postures (if any) during piano playing, thus, achieving healthful playing for injury prevention.
    UNASSIGNED: This study modified (i) the muscle use score; and (ii) the force/load score, from the existing RULA as a rapid assessment for pianists\' posture.
    UNASSIGNED: Proposed the modified RULA for pianists (RULA-p) in the worksheet format.
    UNASSIGNED: Overall, this study is intended to further expand the existing literature on the early prevention of pianists\' PRMDs.
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  • 文章类型: Journal Article
    连同新兴技术一起,已经提出了电解水(EW)系统用于临床领域中的清洁和/或消毒。有证据表明在食品处理和乳制品行业中使用EW,但是缺乏证据表明EW在临床上是有效的清洁和消毒剂。现有出版物大多是基于实验室或来自非临床环境。这与医疗保健清洁中使用的其他方法形成鲜明对比。本文的目的是为感染预防和控制专业人员提供风险评估清单,使用电解水的评估作为引入任何新技术之前所需的分析和考虑的示例,特别是,纳入可持续性。
    Along with emerging technologies electrolysed water (EW) systems have been proposed for cleaning and/or disinfection in clinical areas. There is evidence for the use of EW in food-handling and the dairy industry however there is lack of evidence for EW as an effective cleaning and disinfecting agent in a clinical setting. Existing publications mostly are either laboratory based or from non-clinical settings. This is in direct contrast to other approaches used in healthcare cleaning. The aim of this paper is to provide infection prevention and control professionals with a risk assessment checklist using an evaluation of electrolysed water as an example of the analysis and consideration required prior to the introduction of any new technology and, in particular, the inclusion of sustainability.
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  • 文章类型: Journal Article
    背景:Safewards模型旨在减少冲突和在精神科病房中使用遏制。要评估Safewards的实施情况,并了解为什么它在某些情况下有效,而在其他情况下无效,评估实施保真度的水平很重要。要做到这一点,安全保真度清单(SFC)经常被使用,它侧重于干预措施的客观视觉观察,但不包括患者的反应性。后者是实现保真度的关键指标,包括参与度,相关性,可接受性和实用性。本研究的目的是从患者反应性的角度研究在急性精神病病房中实施Safewards的保真度。
    方法:本研究是在一个主要为情感障碍患者的病房进行的。为了评估总体保真度水平,SFC与详细的病房演练一起使用。对10名患者进行了访谈,重点关注患者对病房实施的7种干预措施中每一种的反应。数据采用定性描述性分析。
    结果:研究结果表明,实现保真度高,这反映在证监会的评估中,演练和患者反应能力。患者给出了随着时间的推移发生的改善或病房比其他病房更好的例子。他们感到受到尊重,不那么孤独,充满希望和安全。他们还描述了支持其他患者并对病房气候负责。然而,一些患者不熟悉期望进行如此多交流的病房。关于改进Safewards提出了一些建议。
    结论:这项研究证实了先前的研究,即患者反应性是在预防计划中实现保真度的重要因素。患者对可接受性的描述,具体干预措施的相关性和实用性在很大程度上反映了通过证监会和病房演练进行的客观视觉观察。关于如何调整干预措施的一些建议证明了患者的参与度。在实践中适应Safewards时,有可能从患者那里获得宝贵的投入。本研究还提供了许多使用这些干预措施的实际工作的例子,以及它对患者护理体验的影响。
    BACKGROUND: The Safewards model aims to reduce conflict and use of containment on psychiatric wards. To evaluate the implementation of Safewards and understand why it is effective in some settings but not in others, it is important to assess the level of implementation fidelity. To do this, the Safewards Fidelity Checklist (SFC) is often used, which focuses on objective visual observations of interventions but does not include patient responsiveness. The latter is a key indicator of implementation fidelity and includes engagement, relevance, acceptability and usefulness. The aim of the present study was to investigate the fidelity of Safewards implementation on an acute psychiatric ward from the perspective of patient responsiveness.
    METHODS: The study was conducted on a ward for patients with mainly affective disorders. To assess the general level of fidelity the SFC was used together with a detailed ward walkthrough. Ten patients were interviewed with a focus on patient responsiveness to each of the seven interventions implemented on the ward. Data were analysed using qualitative descriptive analysis.
    RESULTS: The findings indicate high implementation fidelity, which was reflected in the SFC assessment, walkthrough and patient responsiveness. Patients gave examples of improvements that had happened over time or of the ward being better than other wards. They felt respected, less alone, hopeful and safe. They also described supporting fellow patients and taking responsibility for the ward climate. However, some patients were unfamiliar with a ward where so much communication was expected. Several suggestions were made about improving Safewards.
    CONCLUSIONS: This study confirms previous research that patient responsiveness is an important factor for achieving fidelity in a prevention programme. The patients\' descriptions of the acceptability, relevance and usefulness of the specific interventions reflected to a high degree the objective visual observations made by means of the SFC and ward walkthrough. Patient engagement was demonstrated by several suggestions about how to adapt the interventions. There is potential to obtain valuable input from patients when adapting Safewards in practice. This study also presents many examples of practical work with these interventions and the effects it can have on patients\' experiences of care.
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  • 文章类型: Journal Article
    背景:人们越来越意识到需要将性别和性别充分纳入健康相关研究。尽管众所周知,迄今为止,大多数研究都没有全面考虑纠缠的维度性别/性别,当前有关概念考虑和指南的出版物通常只为研究过程的某些阶段提供建议,并且据我们所知,缺乏伴随整个研究过程每一步的详细指南。跨学科项目“将性别纳入环境卫生研究”(INGER)旨在通过制定全面的清单来填补这一空白,该清单鼓励在定量健康研究研究过程的各个阶段进行性别/性别变革研究。从长远来看,这有助于进行更多的性别/性别平等研究。
    方法:检查表建立在健康相关研究中关于性别/性别的现行指南的基础上。从重要文件入手,收集了参与INGER学科的出版物。此外,我们用滚雪球法加入了更多相关的标题。继续鉴定相关出版物直到达到饱和。确定了2000年至2021年之间出版的55种相关出版物,评估,总结并包括在制定的清单中。在注意到大多数出版物没有涵盖研究过程的每一步,并且经常以二元方式考虑性别/性别之后,根据作者的专业知识对建议进行了修改和丰富,以涵盖每个研究步骤,并在二元性别/性别类别中增加更多类别.
    结果:清单包括15个部分的67个项目,用于将性别/性别纳入与健康相关的定量研究,并涉及整个计划研究过程的各个方面,实施和分析定量健康研究以及适当语言的各个方面,将结果传达给科学界和公众,和研究团队组成。
    结论:开发的综合清单超越了性别/性别的二元考虑,从而实现了性别/性别转化研究。尽管INGER项目专注于环境健康研究,检查表中没有确定本研究领域特有的方面.因此,所得到的综合清单可以用于不同的定量健康相关研究领域。
    BACKGROUND: There is a growing awareness of the need to adequately integrate sex and gender into health-related research. Although it is widely known that the entangled dimensions sex/gender are not comprehensively considered in most studies to date, current publications of conceptual considerations and guidelines often only give recommendations for certain stages of the research process and - to the best of our knowledge - there is a lack of a detailed guidance that accompanies each step of the entire research process. The interdisciplinary project \"Integrating gender into environmental health research\" (INGER) aimed to fill this gap by developing a comprehensive checklist that encourages sex/gender transformative research at all stages of the research process of quantitative health research. In the long term this contributes to a more sex/gender-equitable research.
    METHODS: The checklist builds on current guidelines on sex/gender in health-related research. Starting from important key documents, publications from disciplines involved in INGER were collected. Furthermore, we used a snowball method to include further relevant titles. The identification of relevant publications was continued until saturation was reached. 55 relevant publications published between 2000 and 2021 were identified, assessed, summarised and included in the developed checklist. After noticing that most publications did not cover every step of the research process and often considered sex/gender in a binary way, the recommendations were modified and enriched based on the authors\' expertise to cover every research step and to add further categories to the binary sex/gender categories.
    RESULTS: The checklist comprises 67 items in 15 sections for integrating sex/gender in quantitative health-related research and addresses aspects of the whole research process of planning, implementing and analysing quantitative health studies as well as aspects of appropriate language, communication of results to the scientific community and the public, and research team composition.
    CONCLUSIONS: The developed comprehensive checklist goes beyond a binary consideration of sex/gender and thus enables sex/gender-transformative research. Although the project INGER focused on environmental health research, no aspects that were specific to this research area were identified in the checklist. The resulting comprehensive checklist can therefore be used in different quantitative health-related research fields.
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  • 文章类型: Journal Article
    背景:诊断自闭症谱系障碍的第一阶段通常涉及人群筛查以检测处于危险中的儿童。这项研究旨在评估波兰语版本的沟通和符号行为量表-发育概况婴儿-幼儿清单(CSBS-DPITC)与自闭症频谱等级量表(ASRS)的预测性收敛有效性,评估其敏感性和特异性,并评估在6~24月龄儿童人群筛查中使用该问卷的可能性的分界点.
    方法:该研究是对来自普通人群的602名儿童进行的,这些儿童先前参与了波兰条件问卷的早期验证阶段。对收集的数据进行统计处理,以计算精度(即灵敏度,特异性)的问卷。
    结果:在个别年龄组中,问卷的敏感性为0.667~0.750,特异性为0.854~0.939,阳性预测值为0.261~0.4,阴性预测值为0.979~0.981.筛查精度范围从0.847到0.923,取决于年龄组。采用的分界点是9-12个月儿童21分,36岁为13-18个月的儿童,39岁为19-24个月的儿童。无法为6-8个月的儿童确定截止点。ASRS的收敛效度值范围为-0.28至-0.431,在年龄最大的儿童组中最高。
    结论:这些结果表明,波兰版CSBS-DPITC可用作ASD通用筛查的有效工具。
    BACKGROUND: The first stage of diagnosing autism spectrum disorders usually involves population screening to detect children at risk. This study aims to assess the predictive convergent validity of the Polish version of the Communication and Symbolic Behavior Scales-Developmental Profile Infant-Toddler Checklist (CSBS-DP ITC) with the Autism Spectrum Rating Scales (ASRS), evaluate its sensitivity and specificity and assess the cut-off points for the possibility of using this questionnaire in population screening among children aged 6 to 24 months.
    METHODS: The study was conducted among 602 children from the general population who had previously participated in the earlier phase of validation of the questionnaire for Polish conditions. The collected data were statistically processed to calculate the accuracy (i.e. sensitivity, specificity) of the questionnaire.
    RESULTS: In individual age groups, the sensitivity of the questionnaire varies from 0.667 to 0.750, specificity from 0.854 to 0.939, positive predictive value from 0.261 to 0.4 and negative predictive value-from 0.979 to 0.981. Screening accuracy ranges from 0.847 to 0.923 depending on the age group. The adopted cut-off points are 21 points for children aged 9-12 months, 36 for children aged 13-18 months, 39 for children aged 19-24 months. Cut-off points could not be established for children aged 6-8 months. The convergent validity values with the ASRS ranged from -0.28 to -0.431 and were highest in the group of the oldest children.
    CONCLUSIONS: These results indicate that the Polish version of the CSBS-DP ITC can be used as an effective tool for ASD universal screening.
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  • 文章类型: Journal Article
    Coiba国家公园是巴拿马太平洋一侧的近海地区,它拥有几种特有的动物和植物。2005年被联合国教科文组织宣布为世界遗产。尽管公园被授予了称号,关于其生物多样性的基本要素的知识仍然缺乏,这对管理和保护政策至关重要。例如,直到现在,没有研究监测过公园的动物多样性。
    这里,我们提供了Coiba国家公园的第一个蜘蛛物种清单,包括主岛和几个周围的岛屿。我们在2021年8月至2023年8月进行的几次实地考察中进行了采样。我们确定了至少152个物种(98属和30科),我们报告了三个新的蜘蛛物种为巴拿马,即CtenusnigrolineatusBerland(1913),Zhang和Maddison(2012)和SarindanigraPeckham和Peckham(1892)。我们讨论了我们的结果的含义,并建议未来的工作路线,包括DNA条形码,监测人口和社区动态,加上来自岛上新安装的气象站的气候数据的链接。
    UNASSIGNED: Coiba National Park is an offshore region on the Pacific side of Panama, which hosts several endemic species of animals and plants. It was declared a UNESCO World Heritage Site in 2005. Despite the title awarded to the Park, knowledge about basic elements of its biodiversity are still lacking, which are of vital relevance for management and conservation policies. For instance, until now, no study had ever monitored the araneofauna diversity of the Park.
    UNASSIGNED: Here, we provide the first checklist of spider species in Coiba National Park, including the main island and several surrounding islands. We sampled during several field trips carried out from August 2021 to August 2023. We identified at least 152 species (98 genera and 30 families) and we report three new spiders species for Panama, namely Ctenusnigrolineatus Berland (1913), Chapodagitae Zhang & Maddison (2012) and Sarindanigra Peckham & Peckham (1892). We discuss the implications of our results and recommend future lines of work that include DNA barcoding, monitoring of population and community dynamics, plus linkage of climatic data from the newly-installed meteorological station on the Island.
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  • 文章类型: Journal Article
    背景:急诊和重症监护的进展改善了预后,但是沟通和决策方面的差距仍然存在,尤其是在急诊科(ED),促使开发一份清单,以帮助中国的严重疾病对话(SIC)。
    方法:这是一项单中心前瞻性介入研究,旨在改善SIC用于维持生命治疗(LST)的质量。该研究连续招募患者观察基线和干预阶段,直到结束。符合条件的参与者是入住三级教学医院急诊重症监护病房(EICU)的18岁以上的成年人,拥有完全的决策能力或有合法的代理人。孕妇被排除在外,抵达时死亡的患者,那些拒绝参与的人,以及数据不完整的个人进行分析。首先,组织了两轮Delphi流程,以确定主要元素并通过清单生成标准流程。随后,在实施检查表之前(基线组)和之后(干预组),使用决策冲突量表(DCS)评分比较了入住EICU的成年患者的SIC疗效.
    结果:研究参与者表现出最常见的合并症,比如糖尿病,心肌梗塞,脑血管疾病,中度至重度肾病,充血性心力衰竭,和慢性肺病。基线队列和干预队列之间的中位数Charlson指数没有差异。住院时间中位数为11.0天,82.9%的患者存活到出院。干预组DCS总分低于基线组。三个分量表,包括知情人士,值清晰度,并支持分量表,显示干预组和基线组之间存在显著差异。与基线组相比,干预组患者对心肺复苏(CPR)的同意和改变了主意。
    结论:在EICU中使用SIC检查表通过增加医疗信息披露来降低DCS评分,患者的价值意识,和决策支持。
    BACKGROUND: Advances in emergency and critical care have improved outcomes, but gaps in communication and decision-making persist, especially in the emergency department (ED), prompting the development of a checklist to aid in serious illness conversations (SIC) in China.
    METHODS: This was a single-centre prospective interventional study on the quality improvement of SIC for life-sustaining treatment (LST). The study recruited patients consecutively for both its observational baseline and interventional stages until its conclusion. Eligible participants were adults over 18 years old admitted to the Emergency Intensive Care Unit (EICU) of a tertiary teaching hospital, possessing full decisional capacity or having a legal proxy. Exclusions were made for pregnant women, patients deceased upon arrival, those who refused participation, and individuals with incomplete data for analysis. First, a two-round Delphi process was organized to identify major elements and generate a standard process through a checklist. Subsequently, the efficacy of SIC in adult patients admitted to the EICU was compared using the Decisional Conflict Scale (DCS) score before (baseline group) and after (intervention group) implementing the checklist.
    RESULTS: The study participants presented with the most common comorbidities, such as diabetes, myocardial infarction, cerebrovascular disease, moderate-to-severe renal disease, congestive heart failure, and chronic pulmonary disease. The median Charlson Index did not differ between the baseline and intervention cohorts. The median length of hospital stay was 11.0 days, and 82.9% of patients survived until hospital discharge. The total DCS score was lower in the intervention group than in the baseline group. Three subscales, including the informed, values clarity, and support subscales, demonstrated significant differences between the intervention and baseline groups. Fewer intervention group patients agreed with and changed their minds about cardiopulmonary resuscitation (CPR) compared to the baseline group.
    CONCLUSIONS: The use of a SIC checklist in the EICU reduced the DCS score by increasing medical information disclosure, patient value awareness, and decision-making support.
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