未经证实:女性生殖器血吸虫病(FGS)发生在血吸虫卵沉积在生殖组织中。宫颈粘膜中的女性生殖器血吸虫病与血管增加有关。如果FGS与宫颈阴道灌洗(CVL)中血红蛋白的存在有关,使用尿试纸检测CVL中的血红蛋白可以补充FGS的诊断。
未经批准:非月经,未怀孕,参加HPTN071(PopART)人口队列的18-31岁性活跃女性被邀请到2个赞比亚社区.在一次家访中收集了生殖器自我拭子和尿液样本,CVL和手持式阴道镜检查在助产士主导的诊所就诊中进行。使用尿液试纸鉴定CVL中的血红蛋白。从尿液中检测到鸡蛋和循环阳极抗原(CAA)。视觉FGS被定义为沙质斑块的存在,橡胶状丘疹,或者血管异常.聚合酶链反应(PCR)-FGS定义为通过实时PCR在CVL或宫颈或阴道拭子上检测到的血吸虫脱氧核糖核酸。
未经授权:在209名拥有家庭生殖器拭子和同伴CVL标本的妇女中,66%(209个中的138个)有可检测的CVL血红蛋白,13.4%(209人中有28人)有PCR定义的FGS,17.2%(209人中的36人)有视觉FGS。活动性血吸虫感染,通过CAA或尿液显微镜诊断,21.0%(209人中有44人)的参与者。活动性血吸虫感染(P=4),PCR-FGS(P=0.7),视觉FGS(P=0.3)与CVL血红蛋白的存在无关。结果在感染负荷较高(周期阈值<35或2-3个生殖器PCR阳性)的亚组中没有差异。
未经授权:聚合酶链反应-FGS,visual-FGS,活动性血吸虫感染与CVL血红蛋白的存在无关。需要进一步的研究来建立基于社区的FGS诊断。
UNASSIGNED: Female genital schistosomiasis (FGS) occurs when Schistosoma haematobium eggs are deposited in reproductive tissue. Female genital schistosomiasis in the cervical mucosa is associated with increased vascularity. If FGS is associated with the presence of hemoglobin in cervicovaginal lavage (CVL), the use of urinary reagent strips to detect hemoglobin in CVL could supplement FGS diagnosis.
UNASSIGNED: Nonmenstruating, nonpregnant, sexually active women aged 18-31 participating in the HPTN 071 (PopART) Population-Cohort were invited in 2 Zambian communities. Genital self-swabs and a urine specimen were collected at a home visit, and CVL and hand-held colposcopy were performed at a midwife led clinic visit. Urinary reagent strips were used to identify hemoglobin in CVL. Eggs and circulating anodic antigen (CAA) were detected from urine. Visual-FGS was defined as the presence of sandy patches, rubbery papules, or abnormal blood vessels. Polymerase chain reaction (PCR)-FGS was defined as Schistosoma deoxyribonucleic acid detected by real-time PCR on CVL or cervical or vaginal swab.
UNASSIGNED: Of 209 women with home genital swabs and companion CVL specimens, 66% (138 of 209) had detectable CVL hemoglobin, 13.4% (28 of 209) had PCR-defined FGS, and 17.2% (36 of 209) had visual-FGS. Active Schistosoma infection, diagnosed by CAA or urine microscopy, was present in 21.0% (44 of 209) participants. Active Schistosoma infection (P = .4), PCR-FGS (P = 0.7), and visual-FGS (P = 0.3) were not associated with CVL hemoglobin presence. Results did not differ in subgroups with high infection burden (cycle threshold < 35 or 2-3 positive genital PCR).
UNASSIGNED: Polymerase chain reaction-FGS, visual-FGS, and active Schistosoma infection were not associated with the presence of CVL hemoglobin. Further research is needed to establish accessible community-based FGS diagnostics.