目的:延长机械通气(PMV)和再插管是与宫颈恶性肿瘤相关的最严重的术后不良事件。在这项研究中,我们的目的是澄清发病率,特点,以及目标患者PMV和再插管的危险因素。
方法:这项回顾性巢式病例对照研究于2014年1月至2020年1月在中国一家大型脊柱肿瘤中心进行。单因素分析用于确定与PMV和再插管相关的可能危险因素。进行Logistic回归分析以估计比值比(ORs)和95%置信区间(CIs),其中单变量分析中概率<0.05的协变量。
结果:从560例原发性恶性(n=352)和转移性(n=208)宫颈肿瘤患者的队列中,27例患者需要PMV,20例患者接受了再插管。PMV和再插管的发生率分别为4.82%和3.57%,分别。三个变量(所有p<0.05)与PMV的风险增加独立相关:Karnofsky性能状态<50与≥80相比,手术持续时间≥8小时与<6小时相比,和C4神经根被肿瘤包裹。延长手术时间和术前高碳酸血症(均P<0.05)是术后再插管的独立危险因素,两者都导致住院时间延长(32.6±30.8vs.10.7±5.95天,p<0.001),住院死亡率为17.0%。
结论:我们的结果证明了宫颈恶性肿瘤术后PMV或再插管的危险因素。充分的评估,早期发现,对于这个高危人群来说,预防是必要的。
OBJECTIVE: Prolonged mechanical ventilation (PMV) and reintubation are among the most serious postoperative adverse events associated with malignant cervical tumors. In this study, we aimed to clarify the incidence, characteristics, and risk factors for PMV and reintubation in target patients.
METHODS: This retrospective nested case-control study was performed between January 2014 and January 2020 at a large spinal tumor center in China. Univariate analysis was used to identify the possible risk factors associated with PMV and reintubation. Logistic regression analysis was performed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) with covariates of a probability < 0.05 in univariate analysis.
RESULTS: From a cohort of 560 patients with primary malignant (n = 352) and metastatic (n = 208) cervical tumors, 27 patients required PMV and 20 patients underwent reintubation. The incidence rates of PMV and reintubation were 4.82% and 3.57%, respectively. Three variables (all p < 0.05) were independently associated with an increased risk of PMV: Karnofsky Performance Status < 50 compared to ≥ 80, operation duration ≥ 8 h compared to < 6 h, and C4 nerve root encased by the tumor. Longer operative duration and preoperative hypercapnia (all p < 0.05) were independent risk factors for postoperative reintubation, both of which led to longer length of stay (32.6 ± 30.8 vs. 10.7 ± 5.95 days, p < 0.001), with an in-hospital mortality of 17.0%.
CONCLUSIONS: Our results demonstrate the risk factors for PMV or reintubation after surgery for malignant cervical tumors. Adequate assessment, early detection, and prevention are necessary for this high-risk population.