■脑成像研究可以为观察到的肺功能与痴呆和中风之间的联系提供病因学见解。
我们在ARIC神经认知研究中评估了肺功能测量值与血管和神经退行性疾病的脑MRI标记物的关联。因为很少有研究研究这些关联。
■在1990-1992年(平均年龄=56±5岁)和2011-2013年(平均年龄=76±5岁)的中年参与者中测量了肺功能,脑MRI在2011-2013年进行。线性回归模型用于检查肺功能与脑和白质高强度(WMH)体积的关联。和logistic回归模型用于脑梗死和微出血,调整潜在的混杂因素。
■在横截面分析中(即,检查晚年的肺功能和MRI标记,n=1,223),较高的一秒钟用力呼气量(FEV1)和用力肺活量(FVC)与较大的脑容量和较低的WMH容量相关[例如,8.62(95%CI:2.54-14.71)cm3每升更高的FEV1]。在整个样本中没有发现与微出血的关联,但在不吸烟者中,较高的FVC与较低的微出血几率相关,而在曾吸烟者中,较高的FVC与较低的微出血几率相关.在跨时间分析中(即,与中年肺功能相关,n=1,787),较高的FVC水平与较低的后期脑容量显著相关.
■我们的结果支持较好的肺功能与较少的神经退行性和脑血管病理的适度关联,尽管微出血的发现在吸烟者中是出乎意料的。
UNASSIGNED: Brain imaging studies may provide etiologic insight into observed links between lung function and dementia and stroke.
UNASSIGNED: We evaluated associations of lung function measures with brain MRI markers of vascular and neurodegenerative disease in the ARIC Neurocognitive Study, as few studies have examined the associations.
UNASSIGNED: Lung function was measured at participants\' midlife in 1990-1992 (mean age = 56±5 years) and later-life in 2011-2013 (mean age = 76±5 years), and brain MRI was performed in 2011-2013. Linear regression models were used to examine the associations of lung function with brain and white matter hyperintensity (WMH) volumes, and logistic regression models were used for cerebral infarcts and microbleeds, adjusting for potential confounders.
UNASSIGNED: In cross-sectional analysis (i.e., examining later-life lung function and MRI markers, n = 1,223), higher forced-expiratory volume in one second (FEV1) and forced vital capacity (FVC) were associated with larger brain and lower WMH volumes [e.g., 8.62 (95% CI:2.54-14.71) cm3 greater total brain volume per one-liter higher FEV1]. No association was seen with microbleeds in the overall sample, but higher FVC was associated with lower odds of microbleeds in never-smokers and higher odds in ever-smokers. In the cross-temporal analysis (i.e., associations with midlife lung function, n = 1,787), higher FVC levels were significantly associated with lower later-life brain volumes.
UNASSIGNED: Our results support modest associations of better lung function with less neurodegenerative and cerebrovascular pathology, although findings for microbleeds were unexpected in ever-smokers.