centrality

Centrality
  • 文章类型: Journal Article
    贸易网络将企业联系在一起,而其对企业ESG业绩的影响尚不清楚。借鉴2009-2021年我国资源型企业的不平衡面板数据,将贸易网络分解为基于贸易方向的采购网络和销售网络,并探讨了它们对企业ESG绩效的影响以及所涉及的机制。研究结果表明:(1)贸易网络与企业ESG绩效呈负相关。同时,与销售网络相比,采购网络对企业ESG的不利影响更为明显。经过一系列内生性测试,上述结果仍然有效。(2)异质性分析表明,贸易网络对国有企业ESG绩效的影响更为显著,成熟企业和重污染企业。并且在ESG的治理(G)部分中观察到最明显的负面影响。(3)机理分析发现,贸易网络通过阻碍企业绿色创新和内部控制的进展对企业ESG绩效产生负面影响。(4)加快数字化转型,强化政府环境监管,可以缓解贸易网络对企业ESG绩效的抑制性影响。本研究为资源型企业在加强贸易联系的同时提升ESG绩效提供了理论支持和经验证据。
    Trade network connects enterprises together, while its impact on corporate ESG performance is unknown. Drawing on unbalanced panel data of resource-based enterprises in China from 2009 to 2021, this study decomposes the trade network into purchasing network and sales network based on trade directions, and explores their impact on corporate ESG performance and the mechanisms involved. The findings indicate that: (1) The trade networks exhibit a negative correlation with corporate ESG performance. Meanwhile, purchasing network demonstrates a more pronounced adverse impact on corporate ESG than sales network. After a series of endogeneity tests, the above results still hold. (2) Heterogeneity analysis shows that trade networks have a more significant effect on the ESG performance of state-owned enterprises, mature enterprises and heavily polluting enterprises. And the most pronounced negative effect is observed in the governance (G) component of ESG. (3) Mechanism analysis reveals that trade networks negatively influence corporate ESG performance by impeding the progress of green innovation and internal control. (4) Accelerating digital transformation and intensifying government environmental regulations can mitigate the inhibitory impact of trade networks on corporate ESG performance. This study provides theoretical support and empirical evidence for resource-based enterprises to enhance ESG performance while reinforcing trade linkages.
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  • 文章类型: Journal Article
    事件知识的结构在预测中起着至关重要的作用,重建个人事件的记忆,构建可能的未来事件,行动,语言用法,和社会互动。尽管有许多理论建议,如脚本,schemas,和故事,事件和事件知识的高度可变和丰富的性质一直是描述记忆中事件知识结构的巨大障碍。我们使用网络科学来提供对常见事件的时间结构的见解。根据参与者对构成事件的活动的制作和排序,我们建立了80个常见事件的经验概况,以表征活动的时间结构。我们使用事件网络来调查关于人们对常见事件的知识的丰富性和复杂性的可变性的多个问题,包括:事件的时间结构;可能从许多经验实例中学习并由人们表达的事件原型;场景(社区)在各种事件中存在的程度;人们认为某些活动是事件中心的程度;在事件活动中可能如何分布中心性;以及事件在内容和时间结构方面的相似性。因此,我们提供了对人类事件知识的新见解,并描述了未来人类研究的18个预测。
    The structure of event knowledge plays a critical role in prediction, reconstruction of memory for personal events, construction of possible future events, action, language usage, and social interactions. Despite numerous theoretical proposals such as scripts, schemas, and stories, the highly variable and rich nature of events and event knowledge have been formidable barriers to characterizing the structure of event knowledge in memory. We used network science to provide insights into the temporal structure of common events. Based on participants\' production and ordering of the activities that make up events, we established empirical profiles for 80 common events to characterize the temporal structure of activities. We used the event networks to investigate multiple issues regarding the variability in the richness and complexity of people\'s knowledge of common events, including: the temporal structure of events; event prototypes that might emerge from learning across many experiential instances and be expressed by people; the degree to which scenes (communities) are present in various events; the degree to which people believe certain activities are central to an event; how centrality might be distributed across an event\'s activities; and similarities among events in terms of their content and their temporal structure. Thus, we provide novel insights into human event knowledge, and describe 18 predictions for future human studies.
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  • 文章类型: Journal Article
    这项研究的主要目的是验证和适应葡萄牙人口的宗教量表的中心性。共有1018名受试者参与了这项研究。分析中证明的度量质量表明,因子结构基于与作者提出的五个维度相同的维度。在分析了它的心理测量特性之后,我们得出的结论是,该工具可以应用于葡萄牙人口,并且是与宗教和灵性心理学相关的研究中的宝贵工具。
    The main aim of this study was to validate and adapt the Centrality of Religiosity Scale to the Portuguese population. A total of 1018 subjects participated in this study. The metric qualities demonstrated in the analyses suggested that the factor structure was based on five dimensions identical to those proposed by its authors. After analysing its psychometric qualities, we concluded that this instrument can be applied to the Portuguese population and is a valuable tool in studies related to the psychology of religion and spirituality.
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  • 文章类型: Journal Article
    国内外风险冲击大大增加了我国系统风险管理的需求。本文基于银行间的多种金融关系对中国的多层金融网络进行了估计,资产,和公司,使用2021年中国银行系统数据。提出了一种改进的PageRank算法来识别系统重要性银行和其他经济部门,并进行压力测试。本研究发现,中国的多层金融网络是稀疏的,而整个金融市场的交易分布是不均衡的。监管部门要支持经济复苏,调整货币供应量,而银行应该区分竞争,更好地管理风险。基于PageRank索引,本文从网络结构的角度评估了大型商业银行的系统重要性,强调银行交易行为和市场参与的作用。还评估了不同的行业和资产类别,建议应更加关注行业风险和对银行投资的监管监督。最后,压力测试证实了改进的PageRank算法在多层金融网络中是适用的,加强对银行体系审慎监管的必要性,揭示交易集中度将影响金融机构的系统重要性。
    Domestic and international risk shocks have greatly increased the demand for systemic risk management in China. This paper estimates China\'s multi-layer financial network based on multiple financial relationships among banks, assets, and firms, using China\'s banking system data in 2021. An improved PageRank algorithm is proposed to identify systemically important banks and other economic sectors, and a stress test is conducted. This study finds that China\'s multi-layer financial network is sparse, and the distribution of transactions across financial markets is uneven. Regulatory authorities should support economic recovery and adjust the money supply, while banks should differentiate competition and manage risks better. Based on the PageRank index, this paper assesses the systemic importance of large commercial banks from the perspective of network structure, emphasizing the role of banks\' transaction behavior and market participation. Different industries and asset classes are also assessed, suggesting that increased attention should be paid to industry risks and regulatory oversight of bank investments. Finally, stress tests confirm that the improved PageRank algorithm is applicable within the multi-layer financial network, reinforcing the need for prudential supervision of the banking system and revealing that the degree of transaction concentration will affect the systemic importance of financial institutions.
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  • 文章类型: Journal Article
    娱乐媒体内容经常被称为儿童不健康食品消费的根源之一。这可能是由于儿童媒体环境中存在大量不健康食品。然而,人们对食物放置中心的作用知之甚少,也就是说,食物是否相互作用,消费,口头提到,或者显得不显眼。我们也缺乏纵向研究来衡量儿童的不健康和健康食品消费行为作为结果。
    目的是将基于儿童实际媒体饮食的内容分析数据与面板数据联系起来,以解释儿童的食物偏好。此外,这项研究不仅关注儿童接触的健康和不健康食品的数量,还有这些食物是如何呈现的(即,中央或不中央)。此外,我们研究了父母共同观看如何减少(或增强)不健康(或健康)食物描绘的影响的问题,我们测量健康和不健康的消费作为因变量。
    我们对孩子及其父母之一进行了2波小组研究(与2250名父母联系,829回答,有效率为36.84%;648例有效病例,ie,父子对,用于分析),在2个面板波之间有6个月。我们将儿童及其父母的2波面板数据与儿童在6个月内接触的电影(n=113)和电视连续剧(n=134;每个电视连续剧使用3个随机选择的剧集)的内容分析数据相关联。
    随着时间的推移,暴露于不健康的食物呈现与不健康(b=0.008;P=.07)或健康(b=-0.003;P=.57)食物消耗之间没有显着关系。此外,随着时间的推移,健康食物的呈现与不健康(b=0.009;P=.18)或健康(b=0.000;P=.99)食物消耗无关.然而,有一个重要的,不健康食品的呈现与不健康食品消费的呈现中心性之间的正相互作用(b=0.000;P=0.03),这表明不健康食物呈现的影响随着中心性水平的增加而增加。不健康食品的呈现与健康食品消费的呈现中心之间没有相互作用(b=0.000;P=.10)。此外,暴露于健康食物呈现与中心性相互作用(b=-0.001;P=.003)。也就是说,当一个健康的产品以最大的中心地位呈现时,它减少了儿童不健康的食物消费。在解释不健康(b=0.003;P=.08)或健康(b=-0.001;P=.70)的食物消耗时,观察与不健康食物的暴露没有相互作用。
    我们得出的结论是,仅仅提供更多的健康食品不足以对抗儿童的不健康食品偏好。关于儿童媒体中不健康食品的陈述,可能需要进一步的监管。
    UNASSIGNED: Entertainment media content is often mentioned as one of the roots of children\'s unhealthy food consumption. This might be due to the high quantity of unhealthy foods presented in children\'s media environments. However, less is known about the role of the centrality of food placement, that is, whether foods are interacted with, consumed, verbally mentioned, or appear unobtrusively. We also lack longitudinal research measuring both children\'s unhealthy and healthy food consumption behaviors as outcomes.
    UNASSIGNED: The aim is to connect content analytical data based on children\'s actual media diet with panel data in order to explain children\'s food preferences. Moreover, this study not only focuses on the amount of healthy and unhealthy foods children are exposed to, but also on how these foods are presented (ie, centrally or not). Furthermore, we looked at the question of how parental coviewing can diminish (or enhance) the effects of unhealthy (or healthy) food depictions, and we measured healthy and unhealthy consumption as dependent variables.
    UNASSIGNED: We conducted a 2-wave panel study with children and one of their parents (of 2250 parents contacted, 829 responded, for a response rate of 36.84%; 648 valid cases, ie, parent-child pairs, were used for analysis), with 6 months between the 2 panel waves. We linked the 2-wave panel data for the children and their parents to content analytical data for movies (n=113) and TV series (n=134; 3 randomly chosen episodes per TV series were used) that children were exposed to over the course of 6 months.
    UNASSIGNED: There was no significant relationship between exposure to unhealthy food presentation and unhealthy (b=0.008; P=.07) or healthy (b=-0.003; P=.57) food consumption over time. Also, healthy food presentation was unrelated to unhealthy (b=0.009; P=.18) or healthy (b=0.000; P=.99) food consumption over time. However, there was a significant, positive interaction between unhealthy food presentation and presentation centrality on unhealthy food consumption (b=0.000; P=.03), suggesting that the effects of unhealthy food presentation rise with increasing levels of centrality. There was no interaction between unhealthy food presentation and presentation centrality on the consumption of healthy foods (b=0.000; P=.10). Also, exposure to healthy food presentation interacted with centrality (b=-0.001; P=.003). That is, when a healthy product was presented at maximum centrality, it led to less unhealthy food consumption in children. Coviewing did not interact with exposure to unhealthy foods when explaining unhealthy (b=0.003; P=.08) or healthy (b=-0.001; P=.70) food consumption.
    UNASSIGNED: We conclude that simply presenting more healthy foods is not sufficient to combat children\'s unhealthy food preferences. Further regulations may be necessary with respect to representations of unhealthy foods in children\'s media.
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  • 文章类型: Journal Article
    在这项研究中,我们研究了全球创新网络(GIN)对半导体企业创新产出的影响。利用负二项回归和网络分析,我们评估网络的位置,特别是学位,中间性,和接近中心,影响企业创新绩效,揭示了显著的积极影响。此外,我们的结果确定了GIN中的结构孔与创新绩效之间的正U型关系,这表明,虽然适度的网络参与有助于创新,太多可能是有害的。这项研究为优化GIN参与提供了关键见解,以在竞争激烈的半导体领域获得更好的创新成果。
    In this study, we investigate the influence of global innovation networks (GINs) on the innovation output of semiconductor firms. Utilizing negative binomial regression and network analysis, we assess how network positions, specifically degree, betweenness, and closeness centrality, affect firms\' innovation performance, revealing significant positive impacts. Moreover, our results identify a positive U-shaped relationship between structural holes in GINs and innovation performance, suggesting that while moderate network engagement aids innovation, too much can be detrimental. This research provides key insights into optimizing GIN participation for better innovation results in the competitive semiconductor sector.
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  • 文章类型: Journal Article
    声乐交际在生存中起着重要的作用,繁殖,和动物社会协会。鸟类和哺乳动物会产生复杂的声音序列来传达与上下文相关的信息。发声是大多数无性系物种(青蛙和蟾蜍)行为的显着特征,男性通常根据生态环境改变他们的呼叫策略,以提高吸引力/竞争力。然而,很少有研究关注无声带声带序列的变异。在本研究中,我们使用常规方法和网络分析来研究语境相关的声乐曲目,声乐序列,并称为锯齿腿小树蛙的网络结构。我们发现,在有竞争对手的情况下,雄性牙本质犬通过切换到不同的呼叫类型并增加曲目大小来改变其声音顺序。具体来说,与播放广告通话前后相比,男性发出更少的广告电话,但是更具侵略性的电话,遇到电话,和播放期间的复合呼叫。网络分析显示,平均程度,意味着亲密,在播放期间,呼叫网络的平均介数显著下降,这导致了较低的连通性。此外,单向主题和平均路径长度的比例增加也表明,在竞争环境中,呼叫网络的连通性下降。然而,齿根的声带序列没有显示出清晰的小世界网络结构,无论上下文如何。我们的研究提供了将网络分析应用于无神经声乐序列的范例,对于理解序列模式的进化和功能具有重要意义。
    Vocal communication plays an important role in survival, reproduction, and animal social association. Birds and mammals produce complex vocal sequence to convey context-dependent information. Vocalizations are conspicuous features of the behavior of most anuran species (frogs and toads), and males usually alter their calling strategies according to ecological context to improve the attractiveness/competitiveness. However, very few studies have focused on the variation of vocal sequence in anurans. In the present study, we used both conventional method and network analysis to investigate the context-dependent vocal repertoire, vocal sequence, and call network structure in serrate-legged small treefrogs Kurixalus odontotarsus. We found that male K. odontotarsus modified their vocal sequence by switching to different call types and increasing repertoire size in the presence of a competitive rival. Specifically, compared with before and after the playback of advertisement calls, males emitted fewer advertisement calls, but more aggressive calls, encounter calls, and compound calls during the playback period. Network analysis revealed that the mean degree, mean closeness, and mean betweenness of the call networks significantly decreased during the playback period, which resulted in lower connectivity. In addition, the increased proportion of one-way motifs and average path length also indicated that the connectivity of the call network decreased in competitive context. However, the vocal sequence of K. odontotarsus did not display a clear small-world network structure, regardless of context. Our study presents a paradigm to apply network analysis to vocal sequence in anurans and has important implications for understanding the evolution and function of sequence patterns.
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  • 文章类型: Journal Article
    UNASSIGNED: The Global Health Governance (GHG) response to the COVID-19 pandemic has been criticized, particularly regarding vaccine management, and changes in the roles of GHG actors have been recommended.
    UNASSIGNED: To investigate the perception of experts regarding changes in the roles of different GHG actors following the COVID-19 pandemic.
    UNASSIGNED: This study used a 3-round Delphi survey to collect data from 30 global health experts between May and December 2022. The GHG roles investigated were stewardship, production of guidelines and policies, promotion of solidarity and collaboration, and management of global health challenges. Social network analysis was performed and collected data was converted into a 1-mode network. Degree centrality and Eigenvector centrality were calculated using the UCINET 6.757 modelling programme.
    UNASSIGNED: There were variations between the current and future roles in degree centrality and eigenvector centrality for the 19 GHG actors in each of the 4 functions investigated. For stewardship, WHO, governments and the World Bank had the highest degree centrality and eigenvector centrality during both the current and future periods. In terms of production of guidelines and policies, WHO maintained the highest current and future eigenvector centralities, while research agencies, UNICEF and Gavi upheld their current eigenvector centrality measure. For the promotion of solidarity and collaboration, WHO had the highest centrality measures, followed by UNICEF, governments and Gavi. Regarding the function \"management of global health challenges\", WHO lost its position to UNICEF as the most central, while UNDP, FHI 360 and research agencies were predicted to have a more central role in the future.
    UNASSIGNED: The findings position WHO as the current and future top actor in stewardship, production of guidelines and policies, and promoting solidarity and collaboration, and UNICEF as the upcoming most central actor in managing global health challenges. Governments were major actors in all GHG functions except for managing global health challenges. Funding actors were central in all GHG functions, indicating finance as an important factor in obtaining a central role in GHG. Research organizations received a high centrality rating, indicating their importance in GHG.
    الأدوار المتغيرة في حوكمة الصحة العالمية عقب جائحة كوفيد-19.
    صنجسو شن، وفاء أبو الخير مطرية، حسن الفوال.
    UNASSIGNED: تعرَّضت استجابة حوكمة الصحة العالمية لجائحة كوفيد-19 لانتقادات عدة، لا سيَّما فيما يتعلق بإدارة اللقاحات.
    UNASSIGNED: هدفت هذه الدراسة الى اجراء استقصاءً لتصوُّر الخبراء عن أدوار الجهات الفاعلة المختلفة في مجال حوكمة الصحة العالمية أثناء جائحة كوفيد-19 وبعدها.
    UNASSIGNED: استخدمت هذه الدراسة مسح دلفي من 3 جولات لجمع بيانات من 30 خبيرًا عالميًّا في مجال الصحة في المدة بين مايو/ أيار وديسمبر/ كانون الأول 2022. وشملت الأدوار الخاضعة للاستقصاء: الإشراف، وإعداد المبادئ التوجيهية والسياسات، وتعزيز التضامن والتعاون، وإدارة التحديات الصحية العالمية. وحسبنا درجة المركزية ومركزية المتجه الذاتي باستخدام تحليل الشبكة الاجتماعية. وحُولِّت البيانات التي جرى الحصول عليها إلى شبكة من النمط 1، ثم حُسبت مقاييس المركزية السابقة ببرنامج النمذجة 6,757 UCINET.
    UNASSIGNED: كانت هناك تفاوتات في درجة المركزية ومركزية المتجه الذاتي بالنسبة للجهات الفاعلة البالغ عددها 19 في مجال حوكمة الصحة العالمية في كل وظيفة من الوظائف الأربع التي استُقصيت. فبالنسبة للإشراف، حصلت منظمة الصحة العالمية والحكومات والبنك الدولي على درجات ومركزيات متجه ذاتي أعلى خلال المدتين الحالية والمقبلة. وبالنسبة لإعداد المبادئ التوجيهية والسياسات، حافظت منظمة الصحة العالمية على أعلى مركزيات المتجه الذاتي، في حين استوفت وكالات البحوث واليونيسف والتحالف العالمي من أجل اللقاحات والتمنيع مقياس مركزية المتجه الذاتي الخاص بها. وبالنسبة لتعزيز التضامن والتعاون، حققت منظمة الصحة العالمية أعلى مقاييس المركزية، تلتها اليونيسف والحكومات والتحالف العالمي من أجل اللقاحات والتمنيع. وفيما يتعلق بوظيفة المركزية لإدارة التحديات الصحية العالمية، فقدت منظمة الصحة العالمية مكانتها الأولى لصالح اليونيسف التي حازت تصنيف الأكثر مركزية. واحتفظت منظمة الصحة العالمية واليونيسف فقط بمكانيهما بين أكثر 5 جهات فاعلة مركزية.
    UNASSIGNED: تضع النتائج منظمة الصحة العالمية على رأس الجهات الفاعلة في الإشراف وإعداد المبادئ التوجيهية والسياسات وتعزيز التضامن والتعاون، ووضعت النتائج أيضًا اليونيسف على رأس الجهات الفاعلة المستقبلية الأكثر مركزية في إدارة التحديات الصحية العالمية. وكانت الجهات الفاعلة في مجال التمويل مركزية في جميع وظائف حوكمة الصحة العالمية، وهو ما يشير إلى أن التمويل عامل مهم في الحصول على دور مركزي في مجال حوكمة الصحة العالمية. وقد حصلت المنظمات البحثية على تصنيف مرتفع للمركزية، الأمر الذي يشير إلى أهميتها في مجال حوكمة الصحة العالمية.
    Évolution des rôles dans la gouvernance sanitaire mondiale après la pandémie de COVID-19.
    UNASSIGNED: La réponse apportée dans le cadre de la gouvernance sanitaire mondiale face à la pandémie de COVID-19 a été critiquée, notamment en ce qui concerne la gestion des vaccins, et des changements des rôles des acteurs impliqués dans ce processus ont été recommandés.
    UNASSIGNED: Examiner la perception des experts concernant les changements des rôles des différents acteurs de la gouvernance sanitaire mondiale suite à la pandémie de COVID-19.
    UNASSIGNED: La présente étude a utilisé une enquête en trois tours selon la méthode Delphi en vue de recueillir des données auprès de 30 experts de la santé mondiale entre mai et décembre 2022. Les rôles de la gouvernance sanitaire mondiale examinés étaient la gestion stratégique, la formulation de lignes directrices et de politiques, la promotion de la solidarité et de la collaboration, et la gestion des défis mondiaux en matière de santé. Une analyse des réseaux sociaux a été réalisée et les données obtenues ont été converties en un réseau mode 1. Le degré de centralité et la centralité de vecteur propre ont été calculés à l\'aide du programme de modélisation UCINET 6.757.
    UNASSIGNED: Des variations ont été observées entre les rôles actuels et futurs en termes de degré de centralité et de centralité de vecteur propre pour les 19 acteurs de la gouvernance sanitaire mondiale dans chacune des quatre fonctions étudiées. Pour la gestion stratégique, l\'OMS, les gouvernements et la Banque mondiale présentaient les degrés de centralité et les centralités de vecteur propre les plus élevés, tant pour la période actuelle que pour la période future. En ce qui concerne la formulation de lignes directrices et de politiques, l\'OMS a maintenu la centralité de vecteur propre la plus élevée pour les périodes actuelle et future, tandis que les organismes de recherche, l\'UNICEF et Gavi ont conservé leur mesure actuelle de centralité de vecteur propre. Pour ce qui est de la promotion de la solidarité et de la collaboration, l\'OMS a obtenu les mesures de centralité les plus élevées, suivie de l\'UNICEF, des gouvernements et de Gavi. Enfin, eu égard à la fonction « gestion des défis mondiaux en matière de santé », l\'OMS a cédé sa position au profit de l\'UNICEF qui a obtenu les mesures de centralité les plus élevées, tandis que le PNUD, FHI 360 et les organismes de recherche devraient jouer un rôle davantage central à l\'avenir.
    UNASSIGNED: Les résultats de l\'étude montrent que l\'OMS est l\'acteur principal actuel et futur pour ce qui est de la gestion stratégique, de la formulation de lignes directrices et de politiques, et pour la promotion de la solidarité et de la collaboration, et que l\'UNICEF est l\'organisme qui jouera un rôle central dans la période à venir pour ce qui est de la gestion des défis mondiaux en matière de santé. Les gouvernements ont été des acteurs majeurs dans toutes les fonctions de gouvernance sanitaire mondiale, à l\'exception de la gestion des défis mondiaux en matière de santé. Les acteurs du financement ont joué un rôle central dans toutes les fonctions liées à la gouvernance sanitaire mondiale, ce qui indique que le financement constitue un facteur important pour l\'obtention d\'un tel rôle dans ce domaine. Les organismes de recherche ont reçu une note de centralité élevée, ce qui témoigne de leur importance dans la gouvernance sanitaire mondiale.
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  • 文章类型: Journal Article
    高频振荡是难治性癫痫结果的有希望的生物标志物。先前的高频振荡工作专注于计算单个通道上的高频振荡,目前尚不清楚如何将这些结果转化为临床护理。我们表明,高频振荡是作为网络放电产生的,具有作为预测生物标志物的有价值的特性。这里,我们开发了一种工具来预测患者的预后,在进行手术切除之前,仅基于预期信息。除了确定每个通道上的高频振荡率,我们进行了相关分析,以评估28例颅内电极患者的高频振荡的功能连通性.我们发现高频振荡通常不是单通道上的孤立事件,而是本地网络放电的一部分。特征向量和离网中心性被用来对连接网络中的信道重要性进行排序,然后用于通过与癫痫发作发作区或拟议切除通道内的比例(临界切除百分比)进行比较来比较患者的结果。结合每个患者的癫痫发作发作区切除计划的知识,以及我们计算的高频振荡网络中心性和高频振荡率,我们开发了一种朴素贝叶斯模型,其预测结果(阳性预测值:100%)优于基于完全切除癫痫发作区的预测(阳性预测值:71%).手术切缘对结局有很大影响:切除大部分癫痫发作区的非姑息性患者(“确定性手术”,≥80%切除)有可预测的结果,而姑息性手术(<80%切除)是不可预测的。这些结果表明,在大多数癫痫发作发作区被移除的患者中,高频振荡的网络属性的添加在预测患者结果方面比单独的癫痫发作区更准确,并且为在难治性癫痫的手术中告知临床决策提供了巨大的希望。
    High frequency oscillations are a promising biomarker of outcome in intractable epilepsy. Prior high frequency oscillation work focused on counting high frequency oscillations on individual channels, and it is still unclear how to translate those results into clinical care. We show that high frequency oscillations arise as network discharges that have valuable properties as predictive biomarkers. Here, we develop a tool to predict patient outcome before surgical resection is performed, based on only prospective information. In addition to determining high frequency oscillation rate on every channel, we performed a correlational analysis to evaluate the functional connectivity of high frequency oscillations in 28 patients with intracranial electrodes. We found that high frequency oscillations were often not solitary events on a single channel, but part of a local network discharge. Eigenvector and outcloseness centrality were used to rank channel importance within the connectivity network, then used to compare patient outcome by comparison with the seizure onset zone or a proportion within the proposed resected channels (critical resection percentage). Combining the knowledge of each patient\'s seizure onset zone resection plan along with our computed high frequency oscillation network centralities and high frequency oscillation rate, we develop a Naïve Bayes model that predicts outcome (positive predictive value: 100%) better than predicting based upon fully resecting the seizure onset zone (positive predictive value: 71%). Surgical margins had a large effect on outcomes: non-palliative patients in whom most of the seizure onset zone was resected (\'definitive surgery\', ≥ 80% resected) had predictable outcomes, whereas palliative surgeries (<80% resected) were not predictable. These results suggest that the addition of network properties of high frequency oscillations is more accurate in predicting patient outcome than seizure onset zone alone in patients with most of the seizure onset zone removed and offer great promise for informing clinical decisions in surgery for refractory epilepsy.
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  • 文章类型: Journal Article
    我们研究了来自四个生物地理领域的环境和网络大小对多个跳蚤-哺乳动物网络中物种位置和作用的影响的空间变化。我们询问物种位置(以物种强度[SS]衡量,互动专业化程度[d'],和特征向量中心性[C])或跳蚤及其宿主在相互作用网络中的作用:(a)在跳蚤或宿主物种中可重复/保守;(b)取决于环境变量和/或网络大小;(c)环境和网络大小对网络中物种位置或角色的影响取决于物种性状。441只跳蚤和429种寄主物种的物种位置指数的可重复性分析,发生在至少两个网络中,证明了SS的可重复性,d\',一个物种中的C很重要,虽然不是特别高,这表明指数的值受到当地因素的影响。大多数网络中的大多数跳蚤和宿主物种表现出外围作用。至少一个物种位置指数的值分别受到41和36中环境变量或网络大小的显着影响,在多个网络中发生的52只跳蚤和52种寄主物种中。在跳蚤和宿主中,环境或网络大小对至少一个物种位置指数的显著影响的发生,但不是一个物种在网络中的角色,与一些物种特征有关。
    We studied spatial variation in the effects of environment and network size on species positions and roles in multiple flea-mammal networks from four biogeographic realms. We asked whether species positions (measured as species strength [SS], the degree of interaction specialization [d\'], and the eigenvector centrality [C]) or the roles of fleas and their hosts in the interaction networks: (a) are repeatable/conserved within a flea or a host species; (b) vary in dependence on environmental variables and/or network size; and (c) the effects of environment and network size on species positions or roles in the networks depend on species traits. The repeatability analysis of species position indices for 441 flea and 429 host species, occurring in at least two networks, demonstrated that the repeatability of SS, d\', and C within a species was significant, although not especially high, suggesting that the indices\' values were affected by local factors. The majority of flea and host species in the majority of networks demonstrated a peripheral role. A value of at least one index of species position was significantly affected by environmental variables or network size in 41 and 36, respectively, of the 52 flea and 52 host species that occurred in multiple networks. In both fleas and hosts, the occurrence of the significant effect of environment or network size on at least one index of species position, but not on a species\' role in a network, was associated with some species traits.
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