目的:本研究旨在确定最有效的检测方案,以检测轻度青光眼伴中央视野缺损的视野缺损。
方法:多中心,回顾性诊断测试评估。
方法:该研究涉及93只眼(83例)轻度青光眼(中位数平均偏差[四分位距]:-1.79[2.16]dB),中央视野缺损和69只眼(63例;中位数平均偏差,-1.38[2.31]dB)伴轻度青光眼,无中央视野缺损,来自Jikei大学医学院和TajimiIwase眼科诊所。
方法:患者接受10-2瑞典交互式阈值算法(SITA)标准,24-2SITA标准,和24-2CSITA更快的测试。使用10-2SITA标准和光学相干断层扫描(OCT)定义中心视野缺陷。与10-2(中心4)重合的24-2中的4个点的检测功率,10°以内的12个点(24-2-12),和位于24-2C(24-2C-22)的10°内的22个点使用基于逻辑回归分析的受试者工作特征(ROC)曲线进行分析,使用总偏差(TD)和模式偏差(PD)概率图。
方法:Center4、24-2-12和24-2C-22测试的受试者工作特征曲线(AUC)下面积。
结果:在中央上部视野中,中心4的TD图的AUC为0.50(0.40-0.58),24-2-12的AUC为0.75(0.67-0.83),24-2C-22的AUC为0.85(0.78-0.91),24-2C-22AUC显着超过24-2-12AUC。对于PD图,AUC为0.53(0.44-0.63),0.81(0.74-0.89),和0.84(0.77-0.90),分别。在中心较低的视野中,使用完整的情节,AUC为0.27(0.18-0.36),0.57(0.47-0.69),中心4、24-2-12和24-2C-22分别为0.57(0.46-0.68)。使用上场的PD图,AUC为0.27(0.19-0.36),0.64(0.53-0.75),和0.81(0.72-0.90),分别,24-2C-22的AUC明显超过24-2-12。24-2C测试明显快于24-2和10-2测试,将测试持续时间减少46%和52%,分别。
结论:24-2CSITA更快测试对于检测具有中央视野缺损的轻度青光眼非常有效。这个,和它的持续时间减少,使其在临床环境中成为有价值的工具。
OBJECTIVE: This study sought to identify the most effective testing program for detecting visual-field defects in mild-stage glaucoma with central visual-field defects.
METHODS: A multicenter, retrospective diagnostic testing evaluation.
METHODS: The study involved 93 eyes (83 patients) with mild-stage glaucoma (median mean deviation [interquartile range]: -1.79 [2.16] dB) with central visual-field defects and 69 eyes (63 patients; median mean deviation, -1.38 [2.31] dB) with mild-stage glaucoma without central visual-field defects, from Jikei University School of Medicine and Tajimi Iwase Eye Clinic.
METHODS: Patients underwent 10-2 Swedish Interactive Thresholding Algorithm (SITA) Standard, 24-2 SITA Standard, and 24-2C SITA Faster tests. Central visual-field defects were defined using 10-2 SITA Standard and optical coherence tomography (OCT). A detection power of 4 points in the 24-2 that coincided with 10-2 (Center4), 12 points that lie within 10° (24-2-12), and 22 points that lie within 10° of 24-2C (24-2C-22) were analyzed using receiver operating characteristic (ROC) curves based on logistic regression analysis, using total deviation (TD) and pattern deviation (PD) probability plots.
METHODS: Area under the receiver operating characteristic curve (AUC) of the Center4, 24-2-12, and 24-2C-22 tests.
RESULTS: In the upper-central visual field, AUCs of the TD plot were 0.50 (0.40-0.58) for the Center4, 0.75 (0.67-0.83) for 24-2-12, and 0.85 (0.78-0.91) for 24-2C-22, with 24-2C-22 AUC significantly exceeding 24-2-12 AUC. For the PD plot, AUCs were 0.53 (0.44-0.63), 0.81 (0.74-0.89), and 0.84 (0.77-0.90), respectively. In the lower-central visual field, using a total plot, AUCs were 0.27 (0.18-0.36), 0.57 (0.47-0.69), and 0.57 (0.46-0.68) for the Center4, 24-2-12, and 24-2C-22, respectively. Using the PD plot in the upper field, AUCs were 0.27 (0.19-0.36), 0.64 (0.53-0.75), and 0.81 (0.72-0.90), respectively, with the AUC of the 24-2C-22 significantly exceeding that of 24-2-12. The 24-2C test was significantly faster than both the 24-2 and 10-2 tests, reducing testing duration by 46% and 52%, respectively.
CONCLUSIONS: The 24-2C SITA Faster test is highly effective and efficient for detecting mild-stage glaucoma with central visual-field defects. This, and its reduced duration, makes it a valuable tool in clinical settings.