癌症是一种复杂、异质性的恶性疾病。由于其多因素性质,包括基因的渐进变化,表观遗传,抄本,抄本和蛋白质水平,传统疗法无法挽救癌症患者。证据表明microRNA(miRNA)表达失调在肿瘤发生中起着至关重要的作用。转移,细胞增殖,分化,新陈代谢,和信号通路。此外,miRNA可用作癌症的诊断和预后标志物和治疗靶标。小檗碱,一种天然存在的植物生物碱,在不同类型的癌症中具有广泛的生物活性。抑制细胞增殖,转移,迁移,入侵,和血管生成,以及在癌细胞中诱导细胞周期停滞和凋亡,由小檗碱报道。最近的研究表明,小檗碱调节许多与癌症不同阶段有关的致癌和肿瘤抑制miRNA。本文综述了小檗碱抑制癌细胞生长和增殖以及调节miRNA的作用。以及小檗碱介导的miRNA调控如何改变促进或抑制癌症进展的转录本和蛋白质的景观。总的来说,影响肿瘤病理生理学的小檗碱和miRNA改变的潜在分子途径将增强我们对对抗恶性肿瘤的认识。
Cancer is a complex and heterogeneous malignant disease. Due to its multifactorial nature, including progressive changes in genetic, epigenetic, transcript, and protein levels, conventional therapeutics fail to save cancer patients. Evidence indicates that dysregulation of microRNA (miRNA) expression plays a crucial role in tumorigenesis, metastasis, cell proliferation, differentiation, metabolism, and signaling pathways. Moreover, miRNAs can be used as diagnostic and prognostic markers and therapeutic targets in cancer. Berberine, a naturally occurring plant alkaloid, has a wide spectrum of biological activities in different types of cancers. Inhibition of cell proliferation, metastasis, migration, invasion, and angiogenesis, as well as induction of cell cycle arrest and apoptosis in cancer cells, is reported by berberine. Recent studies suggested that berberine regulates many oncogenic and tumor suppressor miRNAs implicated in different phases of cancer. This review discussed how berberine inhibits cancer growth and propagation and regulates miRNAs in cancer cells. And how berberine-mediated miRNA regulation changes the landscape of transcripts and proteins that promote or suppress cancer progression. Overall, the underlying molecular pathways altered by berberine and miRNA influencing the tumor pathophysiology will enhance our understanding to combat the malignancy.