心脏是一个多细胞系统,细胞间串扰机制对心脏甚至器官的生长发育非常重要,组织,和远处的细胞。作为一种细胞外囊泡,外泌体由不同类型的细胞释放,可以携带特定的遗传物质,内体蛋白,细胞因子,等。,这是调解细胞串扰机制的主要物质基础。其中,由心脏细胞来源的外泌体携带的microRNA具有高度保守的序列,在调节器官功能中起关键作用,组织,以及与心血管疾病及其并发症和合并症有关的细胞,近年来引起了医学界的广泛关注。跟踪国内外最新研究进展,本文系统综述了心脏细胞来源的外泌体microRNA在各种细胞串扰中的调节作用,不仅包括心肌细胞(包括心肌细胞,成纤维细胞,成肌纤维细胞,心脏祖细胞,心脏微血管内皮细胞,心球来源的细胞,等。)但也有肿瘤细胞,骨髓祖细胞,和其他组织细胞,为心血管疾病及其并发症和合并症的防治提供参考。
The heart is a multicellular system, and the intercellular crosstalk mechanism is very important for the growth and development of the heart and even the organs, tissues, and cells at a distance. As a kind of extracellular vesicle, exosomes are released by different types of cells and can carry specific genetic material, endosomal proteins, cytokines, etc., which are the main material basis for mediating cell crosstalk mechanism. Among them, microRNA carried by cardiac cells-derived exosomes have highly conserved sequences and play a key role in regulating the function of organs, tissues, and cells related to cardiovascular diseases and their complications and comorbidities, which have attracted extensive attention in the medical community in recent years. Following up on the latest research progress at home and abroad, this review systematically summarized the regulatory role of microRNA from cardiac cells-derived exosomes in various cell crosstalk, including not only cardiac cells (including cardiomyocytes, fibroblasts, myofibroblast, cardiac progenitor cells, cardiac microvascular endothelial cells, cardiosphere-derived cells, etc.) but also tumor cells, bone marrow progenitor cells, and other tissue cells, in order to provide a reference for the prevention and treatment of cardiovascular diseases and their complications and comorbidities.