■缺乏标准的可修改的心血管危险因素(SMuRF),包括高血压,糖尿病,血脂异常,吸烟,据报道与急性心肌梗死(AMI)的不良预后相关。在没有SMuRF的患者中,癌症和慢性全身性炎症性疾病(CSID)可能是AMI的主要病因。
■本研究的目的是评估癌症患者的临床特征和预后,CSID,AMI中没有SMuRF。
■这项多中心登记包括2,480例接受经皮冠状动脉介入治疗的AMI患者。患者分为4组:活动性癌症,CSID,没有SMuRF,剩下的那些。主要终点为主要不良心血管事件(MACE)和主要出血事件,住院期间和出院后。
■在2,480名患者中,104(4.2%),94(3.8%),和120(4.8%)被归类为癌症,CSID,没有SMuRF,分别。住院期间,无SMuRF组MACE发生率最高,其次是癌症,CSID,和SMuRF组(22.5%vs15.4%vs12.8%vs10.2%;P<0.001),而癌症组的出血风险最高,其次是没有SMuRF,CSID,和SMuRFs组(15.4%vs10.8%vs7.5%vs4.9%;P<0.001)。放电后,癌症组MACE发生率(33.3%vs22.7%vs11.3%vs9.2%;P<0.001)和出血事件发生率(8.6%vs6.7%vs3.8%vs2.9%;P=0.01)高于CSID组,没有SMuRF,和SMuRF组。
■患有活动性癌症的患者,CSID,在住院期间和/或出院后,在AMI后的缺血和出血终点中,SMuRF没有不同的结果,与SMuRF相比。
UNASSIGNED: The lack of standard modifiable cardiovascular risk factors (SMuRFs), including hypertension, diabetes, dyslipidemia, and smoking, is reportedly associated with poor outcomes in acute myocardial infarction (AMI). Among patients with no SMuRFs, cancer and chronic systemic inflammatory diseases (CSIDs) may be major etiologies of AMI.
UNASSIGNED: The purpose of this study was to evaluate clinical characteristics and outcomes of patients with cancer, CSIDs, and no SMuRFs in AMI.
UNASSIGNED: This multicenter registry included 2,480 patients with AMI undergoing percutaneous coronary intervention. Patients were divided into 4 groups: active cancer, CSIDs, no SMuRFs, and those remaining. The coprimary endpoint was major adverse cardiovascular events (MACE) and major bleeding events, during hospitalization and after discharge.
UNASSIGNED: Of 2,480 patients, 104 (4.2%), 94 (3.8%), and 120 (4.8%) were grouped as cancer, CSIDs, and no SMuRFs, respectively. During the hospitalization, MACE rates were highest in the no SMuRFs group, followed by the cancer, CSIDs, and SMuRFs groups (22.5% vs 15.4% vs 12.8% vs 10.2%; P < 0.001), whereas bleeding risks were highest in the cancer group, followed by the no SMuRFs, CSIDs, and SMuRFs groups (15.4% vs 10.8% vs 7.5% vs 4.9%; P < 0.001). After discharge, the rates of MACE (33.3% vs 22.7% vs 11.3% vs 9.2%; P < 0.001) and bleeding events (8.6% vs 6.7% vs 3.8% vs 2.9%; P = 0.01) were higher in the cancer group than in the CSIDs, no SMuRFs, and SMuRFs groups.
UNASSIGNED: Patients with active cancer, CSIDs, and no SMuRFs differently had worse outcomes after AMI in ischemic and bleeding endpoints during hospitalization and/or after discharge, compared with those with SMuRFs.