目的:评估钠葡萄糖转运蛋白2(SGLT2)的表达,炎性细胞因子,和基线时乳房脂肪组织中的沉默调节蛋白,和血清细胞因子的脂肪与无脂肪的绝经前妇女在基线,在12个月的随访中。为了将SGLT2/细胞因子/沉默调节蛋白表达与临床变量相关联,以及它们在随访中的变化(Δ),作为内膜-中膜壁厚(IMT),左心室质量(LVM),左心室射血分数(LVEF),和心肌性能指标(MPI),及其正常化。
背景:绝经前乳腺脂肪密度最低的女性(乳腺脂肪)与乳腺脂肪密度较高(非脂肪型乳腺)是心血管疾病的高危人群,预后较差。
方法:我们分析了脂肪切除的脂肪乳房的SGLT2/细胞因子/沉默调节蛋白与非脂肪的绝经前妇女。我们将SGLT2/细胞因子/沉默调节蛋白与ΔIMT相关联,ΔLVM,ΔLVEF,和ΔMPI,和正常的心脏表现(NCP)在1年的随访。
结果:脂肪与非脂肪乳腺过表达SGLT2/炎性细胞因子,沉默调节蛋白的最低值(p<0.05)。我们发现SGLT2(R20.745)之间存在直接相关性,TNFα(R20.262),和ΔMPI(p<0.05),和乳腺密度之间的负相关(R2-0.198),SIRT-3(R2-0.181),和ΔMPI(p<0.05)。脂肪乳腺(0.761,CI95%[0.101-0.915]),SGLT2(0.812,CI95%[0.674-0.978])和SIRT-3(1.945,CI95%[1.201-3.148])在随访1年时预测NCP。
结论:脂肪与非脂肪乳腺癌女性过度表达SGLT2/炎性细胞因子,和下调的乳房沉默调节蛋白。SGLT2/炎性细胞因子表达与组织沉默蛋白3(tSIRT3)和乳腺百分比密度相反,与1年随访时的ΔMPI相关。脂肪肝和SGLT2反向预测NCP;SIRT-3增加了随访1年的NCP的概率。
To evaluate the expression of sodium-glucose transporter 2 (SGLT2), inflammatory cytokines, and sirtuins in breast fat tissue at baseline, and serum cytokines of fatty vs. non-fatty pre-menopausal women at baseline, and at 12 months of follow-up. To correlate SGLT2/cytokines/sirtuins expression to clinical variables, and their changes (Δ) at follow-up, as intima-media wall thickness (IMT), left ventricle mass (LVM), left ventricle ejection fraction (LVEF), and myocardial performance index (MPI), and its normalization.
Pre-menopausal women with the lowest breast fat density (fatty breast) vs. higher breast fat density (non-fatty breast) are a high-risk population for cardiovascular diseases and worse prognosis.
We analyzed SGLT2/cytokines/sirtuins of excised fatty breasts of fatty vs. non-fatty pre-menopausal women. We correlated SGLT2/cytokines/sirtuins to Δ IMT, Δ LVM, Δ LVEF, and Δ MPI, and normal cardiac performance (NCP) at 1 year of follow-up.
fatty vs. non-fatty breast over-expressed SGLT2/inflammatory cytokines, with lowest values of sirtuins (p<0.05). We found a direct correlation between SGLT2 (R2 0.745), TNFα (R2 0.262), and ΔMPI (p<0.05), and an inverse correlation between breast density (R2 -0.198), SIRT-3 (R2-0.181), and ΔMPI (p<0.05). Fatty breast (0.761, CI 95% [0.101-0.915]), SGLT2 (0.812, CI 95% [0.674-0.978]) and SIRT-3 (1.945, CI 95% [1.201-3.148]) predicted NCP at 1 year of follow-up.
fatty vs. non-fatty breast women over-expressed SGLT2/inflammatory cytokines, and down-regulated breast sirtuins. SGLT2/inflammatory cytokines expression and inversely the tissue sirtuin 3 (tSIRT3) and breast percentage density linked to ΔMPI at 1 year of follow-up. Fatty breast and SGLT2 inversely predicted NCP; SIRT-3 increased the probability of NCP at 1 year of follow-up.