■阻塞性睡眠呼吸暂停综合征(OSAS)合并心力衰竭(HF)已成为威胁人类健康的严重疾病。针对OSAS的治疗干预已被证明可以改善HF患者的预后,因此在HF中识别严重OSAS至关重要。糖类抗原125(CA125)与炎症和容量超负荷有关。HF患者血清中CA125水平升高,HF和OSAS患者可能进一步升高。这项研究的目的是测量有或没有OSAS的HF患者的CA125水平,并分析影响因素。
■在这项单中心回顾性队列研究中,共招募了2021年4月至2022年4月在中大医院住院的95例诊断为HF的患者,其中OSAS患者55例,无OSAS患者40例。有中枢性睡眠呼吸暂停综合征病史的参与者,严重的慢性阻塞性肺疾病,肿瘤,严重感染,或怀孕的人被排除在外。记录了参与者的历史,并进行了实验室检查。进行二元logistic回归分析以确定HF患者血清CA125水平与OSAS之间的关系。
■HF+OSAS组的血清CA125水平高于HF组(29.60vs.9.68U/mL,P<0.001)。根据单变量分析,CA125(>35U/mL)与胸腔积液显著相关,急性HF,呼吸暂停低通气指数(AHI),左心室射血分数(LVEF)和N末端B型利钠肽原(NT-proBNP)水平。最后,AHI在多重分析中显示有统计学意义(OR1.070,95%CI:1.019-1.124,P=0.006)。Spearman秩相关系数分析表明,CA125与AHI呈正相关,Ln(CA125)(Ln是基于e的自然对数)随着AHI的增加而逐渐增加(r=0.551,P<0.0001)。
■HF和OSAS患者的CA125水平进一步升高,CA125(>35U/mL)与AHI呈正相关。作为与炎症和充血相关的生物标志物,血清CA125对HF合并OSAS患者的诊断可能有一定的价值。
UNASSIGNED: Obstructive sleep apnea syndrome (OSAS) combined with heart failure (HF) has become a serious disease that threatens human health. Therapeutic interventions targeting OSAS have been shown to improve outcomes in patients with HF, so the identification of severe OSAS in HF is critical. Carbohydrate antigen 125 (CA125) is associated with inflammation and volume overload. The levels of CA125 are elevated in the serum of patients with HF and might be further elevated in patients with HF and OSAS. The aim of this study was to measure CA125 levels in patients with HF with and without OSAS and to analyze affecting factors.
UNASSIGNED: In this single-center retrospective cohort study, a total of 95 patients diagnosed with HF hospitalized in Zhongda Hospital from April 2021 to April 2022 were recruited, including 55 patients with OSAS and 40 patients without OSAS. Participants with a history of central sleep apnea syndrome, severe chronic obstructive pulmonary disease, tumors, severe infection, or who were pregnant were excluded. The histories of the participants were recorded, and laboratory examinations were performed. Binary logistic regression analysis was performed to determine the relationship between serum CA125 levels and OSAS in patients with HF.
UNASSIGNED: The serum CA125 levels were higher in the HF + OSAS group than in the HF group (29.60 vs. 9.68 U/mL, P<0.001). According to the univariate analysis, CA125 (>35 U/mL) was significantly related to pleural effusion, acute HF, apnea-hypopnea index (AHI), left ventricular ejection fraction (LVEF) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. Finally, the AHI demonstrated statistical significance in multiple analyses (OR 1.070, 95% CI: 1.019-1.124, P=0.006). Spearman rank correlation coefficient analysis showed that CA125 was positively correlated with AHI, and Ln(CA125) (Ln is the natural logarithm based on e) gradually increased with increasing AHI (r=0.551, P<0.0001).
UNASSIGNED: The levels of CA125 were further increased in patients with HF and OSAS, and CA125 (>35 U/mL) was positively correlated with AHI. As a biomarker associated with inflammation and congestion, serum CA125 may have certain value in the diagnosis of patients with HF combined with OSAS.