目的:中链脂肪酸(MCFA)可以快速穿过血脑屏障,为大脑提供替代能源。这项研究旨在确定1)血浆辛酸(C8:0)是否与基线认知正常(CN)参与者中轻度认知障碍(MCI)的风险相关,和基线MCI参与者中的阿尔茨海默病(AD)事件;以及2)这些关联是否因性别而异,心脏代谢疾病的合并症,载脂蛋白E(APOE)ε4等位基因,和ADAS-Cog13。
方法:在阿尔茨海默病神经影像学倡议(ADNI)队列中,在基线时对618名55~91岁无AD参与者的血浆C8:0进行了测量.以事件MCI和AD为因变量,采用Logistic回归模型估计比值比(OR)和95%CI。分开。
结果:循环C8:0与事件MCI风险之间的负相关具有临界意义。在患有≥1种心脏代谢疾病的CN参与者中,循环C8:0水平与发生MCI的风险之间呈负相关[OR(95%CI):0.75(0.58-0.98)(P=0.03)],具有一个拷贝的APOEε4等位基因[OR(95%CI):0.43(0.21-0.89)(P=0.02)],女性[OR(95%CI):0.60(0.38-0.94)(P=0.02)],调整所有协变量后,ADAS-Cog13高于中位数[OR(95CI):0.69(0.50-0.97)(P=0.03)]。
结论:仅在CN参与者的亚组之间存在负相关,包括女性个人,患有一种或多种心脏代谢疾病的人,或者一个APOEε4等位基因,或更高的ADAS-Cog13分数。如果确认,这一发现将有助于MCI的精确预防,CN老年人中的AD。
Medium-chain fatty acids (MCFAs) can rapidly cross the blood-brain barrier and provide an alternative energy source for the brain. This study aims to determine 1) whether plasma caprylic acid (C8:0) is associated with risk of incident mild cognitive impairment (MCI) among baseline cognitively normal (CN) participants, and incident Alzheimer\'s Disease (AD) among baseline MCI participants; and 2) whether these associations differ by sex, comorbidity of cardiometabolic diseases, apolipoprotein E (APOE) ε4 alleles, and ADAS-Cog 13.
Within the Alzheimer\'s Disease Neuroimaging Initiative (ADNI) cohort, plasma C8:0 was measured at baseline in 618 AD-free participants aged 55 to 91. Logistic regression models were used to estimate odds ratios (ORs) and 95% CIs with incident MCI and AD as dependent variables, separately.
The inverse association between circulating C8:0 and risk of incident MCI was of borderline significance. The inverse association between circulating levels of C8:0 and risk of incident MCI was significant among CN participants with ≥1 cardiometabolic diseases [OR (95% CI): 0.75 (0.58-0.98) (P=0.03)], those with one copy of APOE ε4 alleles [OR (95% CI): 0.43 (0.21-0.89) (P=0.02)], female [OR (95% CI): 0.60 (0.38-0.94) (P=0.02)], and ADAS-Cog 13 above the median [OR (95%CI): 0.69 (0.50-0.97)(P=0.03)] after adjusting for all covariates.
The inverse associations were present only among subgroups of CN participants, including female individuals, those with one or more cardiometabolic diseases, or one APOE ε4 allele, or higher ADAS-Cog 13 scores. If confirmed, this finding will facilitate precision prevention of MCI, in turn, AD among CN older adults.